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Although there has been great progress in the study of the mechanism of white matter injury in newborn infants, its pathogenesis is not entirely clear, and further treatment approaches are required. Animal models are the basis of study in pathogenesis, treatment, and prognosis of white matter injury in preterm infants. Various species have been used to establish white matter injury models, including rodents, rabbits, sheep, and non-human primates. Small animal models allow cost-effective investigation of molecular and cellular mechanisms, while large animal models are particularly attractive for pathophysiological and clinical-translational studies. This review focuses on the features of commonly used white matter injury animal models, including their modelling methods, advantages, and limitations, and addresses some clinically relevant animal models that allow reproduction of the insults associated with clinical conditions that contribute to white matter injury in human infants.<\/jats:p>","DOI":"10.1515\/revneuro-2018-0044","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T09:03:17Z","timestamp":1540976597000},"page":"245-259","source":"Crossref","is-referenced-by-count":15,"title":["The optimal choices of animal models of white matter injury"],"prefix":"10.1515","volume":"30","author":[{"given":"Yan","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Pediatrics , West China Second University Hospital, Sichuan University , Chengdu 610041 , China"},{"name":"Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education , Sichuan University , Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , West China Second University Hospital, Sichuan University , Chengdu 610041 , China"},{"name":"Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education , Sichuan University , Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , West China Second University Hospital, Sichuan University , Chengdu 610041 , China"},{"name":"Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education , Sichuan University , Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , West China Second University Hospital, Sichuan University , Chengdu 610041 , China"},{"name":"Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education , Sichuan University , Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , West China Second University Hospital, Sichuan University , Chengdu 610041 , China"},{"name":"Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education , Sichuan University , Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqiong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , West China Second University Hospital, Sichuan University , Chengdu 610041 , China"},{"name":"Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education , Sichuan University , Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , West China Second University Hospital, Sichuan University , Chengdu 610041 , China"},{"name":"Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education , Sichuan University , Chengdu 610041 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhi","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics , West China Second University Hospital, Sichuan University , No. 20, section 3, Renmin South Road, Chengdu, Sichuan 610041 , China"},{"name":"Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education , Sichuan University , Chengdu 610041 , China , Telephone: +86-28-85503226, Fax: +86-28-85559065"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,10,31]]},"reference":[{"key":"2023040103032567613_j_revneuro-2018-0044_ref_001_w2aab3b7b8b1b6b1ab1b6b1Aa","doi-asserted-by":"crossref","unstructured":"Albertsson, A.-M., Bi, D., Duan, L., Zhang, X., Leavenworth, J.W., Qiao, L., and Hagberg, H. 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