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It appears in different parts of the brain as A\u03b2 plaques, neurofibrillary tangles, Lewy bodies, Pick bodies, and others, which leads to Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, amyotrophic lateral sclerosis, and other diseases. So far, no specific treatment has been identified for these diseases. Despite common treatments that help to prevent the development of disease, the condition of patients with progressive neurodegenerative diseases usually do not completely improve. Currently, the use of flavonoids, especially quercetin for the treatment of neurodegenerative diseases, has been expanded in animal models. It has also been used to treat animal models of neurodegenerative diseases. In addition, improvements in behavioral levels, as well as in cellular and molecular levels, decreased activity of antioxidant and apoptotic proteins, and increased levels of antiapoptotic proteins have been observed. Low bioavailability of quercetin has also led researchers to construct various quercetin-involved nanoparticles. The treatment of animal models of neurodegeneration using quercetin-involved nanoparticles has shown that improvements are observed in shorter periods and with use of lower concentrations. Indeed, intranasal administration of quercetin-involved nanoparticles, constructing superparamagnetic nanoparticles, and combinational treatment using nanoparticles such as quercetin and other drugs are suggested for future studies.<\/jats:p>","DOI":"10.1515\/revneuro-2018-0080","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T09:12:27Z","timestamp":1549962747000},"page":"555-572","source":"Crossref","is-referenced-by-count":91,"title":["Application of quercetin in neurological disorders: from nutrition to nanomedicine"],"prefix":"10.1515","volume":"30","author":[{"given":"Elnaz","family":"Amanzadeh","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Sciences , University of Isfahan , Isfahan 8174673441 , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolghasem","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences , University of Isfahan , Isfahan 8174673441 , Iran , e-mail:"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheila","family":"Rahgozar","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences , University of Isfahan , Isfahan 8174673441 , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Nourbakhshnia","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences , University of Isfahan , Isfahan 8174673441 , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"key":"2024080910125756282_j_revneuro-2018-0080_ref_001_w2aab3b7b9b1b6b1ab1c10b1Aa","doi-asserted-by":"crossref","unstructured":"Abraham, M.H. and Acree, W.E. 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