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Sulfite oxidase (SUOX), which is a molybdenum-containing protein, could be dysregulated in AD. SUOX detoxifies the sulfites. Glutaminergic neurotransmission could be dysregulated in AD due to low levels of SUOX and high levels of sulfites. L-cysteine provides sulfur for iron-sulfur clusters. Oxidative phosphorylation (OXPHOS) is heavily dependent on iron-sulfur proteins. The decrease in OXPHOS seen in AD could be due to dysregulations of the trans-sulfuration pathway. There is a decrease in aconitase 1 (ACO1) in AD. ACO1 is an iron-sulfur enzyme in the citric acid cycle that upon loss of an iron-sulfur cluster converts to iron regulatory protein 1 (IRP1). With the dysregulation of iron-sulfur cluster formation ACO1 will convert to IRP1 which will decrease the 2-oxglutarate synthesis dysregulating the citric acid cycle and also dysregulating iron metabolism. Selenomethionine is also metabolized by the trans-sulfuration pathway. With the low activity of the trans-sulfuration pathway in AD selenoproteins will be dysregulated in AD. Dysregulation of selenoproteins could lead to oxidant stress in AD. In this article, we propose a novel treatment for AD that addresses dysregulations resulting from low activity of the trans-sulfuration pathway and low L-cysteine.<\/jats:p>","DOI":"10.1515\/revneuro-2019-0076","type":"journal-article","created":{"date-parts":[[2019,11,21]],"date-time":"2019-11-21T04:03:08Z","timestamp":1574308988000},"page":"319-334","source":"Crossref","is-referenced-by-count":15,"title":["A disease-modifying treatment for Alzheimer\u2019s disease: focus on the trans-sulfuration pathway"],"prefix":"10.1515","volume":"31","author":[{"given":"Thomas","family":"Berry","sequence":"first","affiliation":[{"name":"School of Social Sciences and Psychology , Western Sydney University , 2 Bullecourt Ave, Milperra, 2214 Sydney , New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eid","family":"Abohamza","sequence":"additional","affiliation":[{"name":"Department of Social Sciences , College of Arts and Sciences, Qatar University , Doha , Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Moustafa","sequence":"additional","affiliation":[{"name":"School of Social Sciences and Psychology , Western Sydney University , 2 Bullecourt Ave, Milperra, 2214 Sydney , New South Wales , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"key":"2022062616292437995_j_revneuro-2019-0076_ref_001_w2aab3b7c20b1b6b1ab2ab1Aa","doi-asserted-by":"crossref","unstructured":"Abdelazim, I.A., Abu-Faza, M., Shikanova, S., Zhurabekova, G., and Maghrabi, M.M. 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