{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:50:52Z","timestamp":1790391052612,"version":"4.1.0"},"reference-count":39,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_rir-2025-0003_s_101\">\n                  <jats:title>Background and Objectives<\/jats:title>\n                  <jats:p>Familial Mediterranean fever (FMF) stands as a significant challenge within Jordan\u2019s clinical practice, despite its low prevalence of 0.04% within the Jordanian population. This study aims to investigate the current status of the health status of FMF patients in Jordan while exploring any present associations between chronic diseases and the severity of their symptoms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_rir-2025-0003_s_102\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a cross-sectional descriptive survey-based study conducted during the period between 1st of March till the last of May 2023 in Jordan. The survey was distributed randomly to a group of FMF patients, Sample size was based on FMF prevalence in Jordan (0.04%); study sample (<jats:italic>N<\/jats:italic> = 67) included FMF patients in Jordan from different age groups. All results were performed through proper statistical analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_rir-2025-0003_s_103\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study includes 67 FMF patients, predominantly Jordanian and aged 18\u201331, revealed that 58.2% only were diagnosed through blood genetic testing. Marriages among first-degree relatives showed a 60% probability of FMF transmission compared to 10% in non-related parents (<jats:italic>P<\/jats:italic> = 0.001), leading 82.1% of participants to call for pre-marital testing. Acute symptoms included abdominal pain, fever, arthralgia, and myalgia, with hypertension being the most frequent comorbidity (14.9%) and significantly associated with myalgia and arthralgia (<jats:italic>P<\/jats:italic> &lt; 0.05). Colchicine was the primary treatment for 89.6% of patients, with high adherence rates (90.3%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_rir-2025-0003_s_104\">\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Among chronic comorbidities, hypertension was associated in increasing the severity of the myalgia during attacks. The issue of misdiagnosis remains a major challenge in Jordanian clinical practice. Our findings assert the importance of future incorporation of FMF premarital testing.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/rir-2025-0003","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T07:52:04Z","timestamp":1743666724000},"page":"21-28","source":"Crossref","is-referenced-by-count":1,"title":["Insights into familial Mediterranean fever: Chronic disease correlations with arthralgia and current health status of patients with familial Mediterranean fever in Jordan"],"prefix":"10.1515","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2433-4083","authenticated-orcid":false,"given":"Mai I.","family":"Al-Hawamdeh","sequence":"first","affiliation":[{"name":"Department of pharmacy, College of pharmacy, Amman Arab University , Amman , Jordan"},{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University Of Jordan , Amman , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Othman","sequence":"additional","affiliation":[{"name":"Department of pharmacy, College of pharmacy, Amman Arab University , Amman , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safaa\u2019","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of pharmacy, College of pharmacy, Amman Arab University , Amman , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tityana","family":"Adaw\u0131","sequence":"additional","affiliation":[{"name":"Department of pharmacy, College of pharmacy, Amman Arab University , Amman , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talal","family":"Aburja\u0131","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, The University Of Jordan , Amman , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"2025040307331987887_j_rir-2025-0003_ref_001","doi-asserted-by":"crossref","unstructured":"Hamamy H, Al-Hait S, Alwan A, et al. Jordan: communities and community genetics. Community Genet. 2007;10:52\u201360.","DOI":"10.1159\/000096282"},{"key":"2025040307331987887_j_rir-2025-0003_ref_002","doi-asserted-by":"crossref","unstructured":"Schnappauf O, Chae JJ, Kastner DL, et al. The Pyrin Inflammasome in Health and Disease. Front Immunol. 2019;10:1745.","DOI":"10.3389\/fimmu.2019.01745"},{"key":"2025040307331987887_j_rir-2025-0003_ref_003","doi-asserted-by":"crossref","unstructured":"Sar\u0131 \u0130, Birlik M, Kasifo\u011flu T. Familial Mediterranean fever: An updated review. Eur J Rheumatol. 2014;1:21\u201333.","DOI":"10.5152\/eurjrheum.2014.006"},{"key":"2025040307331987887_j_rir-2025-0003_ref_004","doi-asserted-by":"crossref","unstructured":"Demirkaya E, Acikel C, Hashkes P, et al. Development and initial validation of international severity scoring system for familial Mediterranean fever (ISSF). Ann Rheum Dis. 2016;75:1051\u20131056.","DOI":"10.1136\/annrheumdis-2015-208671"},{"key":"2025040307331987887_j_rir-2025-0003_ref_005","doi-asserted-by":"crossref","unstructured":"Piram M, Kon\u00e9-Paut I, Lachmann HJ, et al. Validation of the auto-inflammatory diseases activity index (AIDAI) for hereditary recurrent fever syndromes. Ann Rheum Dis. 2014;73:2168\u20132173.","DOI":"10.1136\/annrheumdis-2013-203666"},{"key":"2025040307331987887_j_rir-2025-0003_ref_006","doi-asserted-by":"crossref","unstructured":"Ter Haar NM, Annink KV, Al-Mayouf SM, et al. Development of the autoinflammatory disease damage index (ADDI). Ann Rheum Dis. 2017;76:821\u2013830.","DOI":"10.1136\/annrheumdis-2016-210918"},{"key":"2025040307331987887_j_rir-2025-0003_ref_007","doi-asserted-by":"crossref","unstructured":"Tezcan M, \u015een N, Yilmaz M, et al. SAT0541 the severity of fmf may be associated with co-morbidities. Ann Rheum Dis. 2020;79:1227\u20131228.","DOI":"10.1136\/annrheumdis-2020-eular.801"},{"key":"2025040307331987887_j_rir-2025-0003_ref_008","unstructured":"Khan S, Karjoo M, Karjoo S. Familial mediterranean fever: Review of literature and report of two cases. Int J Pediatr. 2017;5:6469\u20136484."},{"key":"2025040307331987887_j_rir-2025-0003_ref_009","doi-asserted-by":"crossref","unstructured":"S\u00f6nmez HE, Batu ED, \u00d6zen S. Familial Mediterranean fever: current perspectives. J Inflamm Res. 2016;9:13\u201320.","DOI":"10.2147\/JIR.S91352"},{"key":"2025040307331987887_j_rir-2025-0003_ref_010","doi-asserted-by":"crossref","unstructured":"Yal\u00e7inkaya F, Ozen S, Oz\u00e7akar ZB, et al. A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology (Oxford). 2009;48:395\u2013398.","DOI":"10.1093\/rheumatology\/ken509"},{"key":"2025040307331987887_j_rir-2025-0003_ref_011","doi-asserted-by":"crossref","unstructured":"Georgin-Lavialle S, Hentgen V, Stankovic Stojanovic K, et al. [Familial Mediterranean fever]. Rev Med Interne. 2018;39:240\u2013255.","DOI":"10.1016\/j.revmed.2018.02.005"},{"key":"2025040307331987887_j_rir-2025-0003_ref_012","doi-asserted-by":"crossref","unstructured":"Ravelli RB, Gigant B, Curmi PA, et al. Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain. Nature. 2004;428:198\u2013202.","DOI":"10.1038\/nature02393"},{"key":"2025040307331987887_j_rir-2025-0003_ref_013","doi-asserted-by":"crossref","unstructured":"Ozen S. Update in familial Mediterranean fever. Curr Opin Rheumatol. 2021;33:398\u2013402.","DOI":"10.1097\/BOR.0000000000000821"},{"key":"2025040307331987887_j_rir-2025-0003_ref_014","doi-asserted-by":"crossref","unstructured":"Alzyoud R, Alsweiti M, Maittah H, et al. Familial Mediterranean fever in Jordanian Children: single centre experience. Mediterr J Rheumatol. 2018;29:211\u2013216.","DOI":"10.31138\/mjr.29.4.211"},{"key":"2025040307331987887_j_rir-2025-0003_ref_015","doi-asserted-by":"crossref","unstructured":"Medlej-Hashim M, Rawashdeh M, Chouery E, et al. Genetic screening of fourteen mutations in Jordanian familial Mediterranean fever patients. Hum Mutat. 2000;15:384.","DOI":"10.1002\/(SICI)1098-1004(200004)15:4<384::AID-HUMU19>3.0.CO;2-U"},{"key":"2025040307331987887_j_rir-2025-0003_ref_016","doi-asserted-by":"crossref","unstructured":"Rawashdeh MO, Majeed HA. Familial Mediterranean fever in Arab children: the high prevalence and gene frequency. Eur J Pediatr. 1996;155:540\u2013544.","DOI":"10.1007\/BF01957901"},{"key":"2025040307331987887_j_rir-2025-0003_ref_017","doi-asserted-by":"crossref","unstructured":"Siligato R, Gembillo G, Calabrese V, et al. Amyloidosis and Glomerular Diseases in Familial Mediterranean Fever. Medicina (Kaunas). 2021;57:1049.","DOI":"10.3390\/medicina57101049"},{"key":"2025040307331987887_j_rir-2025-0003_ref_018","doi-asserted-by":"crossref","unstructured":"Wu B, Xu T, Li Y, et al. Interventions for reducing inflammation in familial Mediterranean fever. Cochrane Database Syst Rev. 2015:CD010893.","DOI":"10.1002\/14651858.CD010893.pub2"},{"key":"2025040307331987887_j_rir-2025-0003_ref_019","doi-asserted-by":"crossref","unstructured":"Charan J, Biswas T. How to calculate sample size for different study designs in medical research? Indian J Psychol Med. 2013;35:121\u2013126.","DOI":"10.4103\/0253-7176.116232"},{"key":"2025040307331987887_j_rir-2025-0003_ref_020","unstructured":"Pourhoseingholi MA, Vahedi M, Rahimzadeh M. Sample size calculation in medical studies. Gastroenterol Hepatol Bed Bench. 2013;6:14-17."},{"key":"2025040307331987887_j_rir-2025-0003_ref_021","unstructured":"Khaled Fahim N, Negida A. Sample Size Calculation Guide - Part 1: How to Calculate the Sample Size Based on the Prevalence Rate. Adv J Emerg Med. 2018;2:e50."},{"key":"2025040307331987887_j_rir-2025-0003_ref_022","doi-asserted-by":"crossref","unstructured":"Hamamy H, Al-Hait S, Alwan A, et al. Jordan: communities and community genetics. Community Genet. 2007;10:52\u201360.","DOI":"10.1159\/000096282"},{"key":"2025040307331987887_j_rir-2025-0003_ref_023","doi-asserted-by":"crossref","unstructured":"\u00d6zen S, Batu ED, Demir S. Familial Mediterranean Fever: Recent Developments in Pathogenesis and New Recommendations for Management. Front Immunol. 2017;8:253.","DOI":"10.3389\/fimmu.2017.00253"},{"key":"2025040307331987887_j_rir-2025-0003_ref_024","doi-asserted-by":"crossref","unstructured":"Lachmann HJ, Seng\u00fcl B, Yavuz\u015fen TU, et al. Clinical and sub-clinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology (Oxford). 2006;45:746\u2013750.","DOI":"10.1093\/rheumatology\/kei279"},{"key":"2025040307331987887_j_rir-2025-0003_ref_025","doi-asserted-by":"crossref","unstructured":"Ben-Chetrit E, Lerer I, Malamud E, et al. The E148Q mutation in the MEFV gene: is it a disease-causing mutation or a sequence variant? Hum Mutat. 2000;15:385\u2013386.","DOI":"10.1002\/(SICI)1098-1004(200004)15:4<385::AID-HUMU22>3.0.CO;2-A"},{"key":"2025040307331987887_j_rir-2025-0003_ref_026","doi-asserted-by":"crossref","unstructured":"Akik C, Ghattas H, Mesmar S, et al. Host country responses to non-communicable diseases amongst Syrian refugees: a review. Confl Health. 2019;13:8.","DOI":"10.1186\/s13031-019-0192-2"},{"key":"2025040307331987887_j_rir-2025-0003_ref_027","doi-asserted-by":"crossref","unstructured":"Hamad L, Kreidieh K, Hamdan MB, et al. Mapping the Diverse Genetic Disorders and Rare Diseases Among the Syrian Population: Implications on Refugee Health and Health Services in Host Countries. J Immigr Minor Health. 2020;22:1347\u20131367.","DOI":"10.1007\/s10903-020-00987-7"},{"key":"2025040307331987887_j_rir-2025-0003_ref_028","unstructured":"Erdogan M, Ugurlu S, Ozdogan H, et al. Familial Mediterranean fever: misdiagnosis and diagnostic delay in Turkey. Clin Exp Rheumatol. 2019;37 Suppl 121:119-124."},{"key":"2025040307331987887_j_rir-2025-0003_ref_029","doi-asserted-by":"crossref","unstructured":"Baspinar S, Alkan A, Yuzbasioglu M, et al. AB1322 appendicitis still a misdiagnosis for fmf patients. Ann Rheum Dis. 2022;81:1767.","DOI":"10.1136\/annrheumdis-2022-eular.5167"},{"key":"2025040307331987887_j_rir-2025-0003_ref_030","unstructured":"Li J, Zhang Y, Wang W, et al. [Three cases with familial Mediterranean fever misdiagnosed as juvenile idiopathic arthritis]. Zhonghua Er Ke Za Zhi. 2017;55:383-387."},{"key":"2025040307331987887_j_rir-2025-0003_ref_031","doi-asserted-by":"crossref","unstructured":"Ka\u015fifo\u011flu T, Cansu DU, Korkmaz C. Frequency of abdominal surgery in patients with familial Mediterranean fever. Intern Med. 2009;48:523\u2013526.","DOI":"10.2169\/internalmedicine.48.1602"},{"key":"2025040307331987887_j_rir-2025-0003_ref_032","doi-asserted-by":"crossref","unstructured":"Lancieri M, Bustaffa M, Palmeri S, et al. An Update on Familial Mediterranean Fever. Int J Mol Sci. 2023;24:9584.","DOI":"10.3390\/ijms24119584"},{"key":"2025040307331987887_j_rir-2025-0003_ref_033","unstructured":"Durmu\u015f FB, Yusufo\u01e7lu C, Ekinci \u00d6. Colchicine-related depressive symptoms in a child. Psychiatry Clin Psychopharmacol. 2019;29:232."},{"key":"2025040307331987887_j_rir-2025-0003_ref_034","doi-asserted-by":"crossref","unstructured":"Makay B, Unsal E. Altered circadian rhythm: possible trigger of familial Mediterranean fever attacks. Med Hypotheses. 2009;73:630\u2013631.","DOI":"10.1016\/j.mehy.2009.06.019"},{"key":"2025040307331987887_j_rir-2025-0003_ref_035","doi-asserted-by":"crossref","unstructured":"Sbeih N, Bourguiba R, Hoyeau-Idrissi N, et al. Histamine elevation in familial Mediterranean fever: A study from the Juvenile Inflammatory Rheumatism cohort. Eur J Intern Med. 2023;116:89\u201395.","DOI":"10.1016\/j.ejim.2023.06.009"},{"key":"2025040307331987887_j_rir-2025-0003_ref_036","doi-asserted-by":"crossref","unstructured":"Alsarah A, Alsara O, Laird-Fick HS. Cardiac manifestations of Familial Mediterranean fever. Avicenna J Med. 2017;7:158\u2013163.","DOI":"10.4103\/ajm.AJM_78_17"},{"key":"2025040307331987887_j_rir-2025-0003_ref_037","doi-asserted-by":"crossref","unstructured":"Malik J, Shabbir A, Nazir A. Cardiovascular Sequelae and Genetics of Familial Mediterranean Fever: A Literature Review. Pulse (Basel). 2021;8:78-85.","DOI":"10.1159\/000516182"},{"key":"2025040307331987887_j_rir-2025-0003_ref_038","doi-asserted-by":"crossref","unstructured":"Ayd\u0131n F, \u00c7akar N, \u00d6z\u00e7akar ZB, et al. Clinical features and disease severity of Turkish FMF children carrying E148Q mutation. J Clin Lab Anal. 2019;33:e22852.","DOI":"10.1002\/jcla.22852"},{"key":"2025040307331987887_j_rir-2025-0003_ref_039","doi-asserted-by":"crossref","unstructured":"Tufan A, Lachmann HJ. Familial Mediterranean fever, from pathogenesis to treatment: a contemporary review. Turk J Med Sci. 2020;5:1591-1610.","DOI":"10.3906\/sag-2008-11"}],"container-title":["Rheumatology and Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/rir-2025-0003\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/rir-2025-0003\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T07:53:08Z","timestamp":1743666788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/rir-2025-0003\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,1]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,4,2]]},"published-print":{"date-parts":[[2025,4,2]]}},"alternative-id":["10.1515\/rir-2025-0003"],"URL":"https:\/\/doi.org\/10.1515\/rir-2025-0003","relation":{},"ISSN":["2719-4523"],"issn-type":[{"value":"2719-4523","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,1]]}}}