{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:45:57Z","timestamp":1785789957304,"version":"3.56.0"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_rir-2025-0020_s_016\">\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the prognostic value of stroke volume index (SVI) compared to cardiac index (CI) in risk stratification and outcome prediction in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_rir-2025-0020_s_017\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective analysis of patients diagnosed with CTD-PAH through right heart catheterization (RHC) from two Chinese medical centers. This retrospective study analyzed 206 CTD-PAH patients, with risk stratification performed using the 2018 World Symposia on Pulmonary Hypertension (WSPH) framework. Restricted cubic splines (RCS) and log-rank tests were utilized to identify the optimal SVI cutof values for categorizing patients into low-, intermediate-, and high-risk groups. Kaplan-Meier (KM) curves were used to analyze survival rates and event-free survival. Receiver operating characteristic (ROC) analysis was used to assess the predictive accuracy of diferent models for prognostic outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_rir-2025-0020_s_018\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SVI was categorized into low-risk (SVI \u2265 33.35 mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), intermediate-risk (24.66 mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      \u2264 SVI &lt; 33.35 mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      ), and high-risk (SVI &lt; 24.66 mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) groups. Among the 206 CTD-PAH patients, 55 exhibited discrepancies in risk stratification between CI and SVI. SVI-based stratification provided more accurate risk categorization and demonstrated superior predictive value compared to CI, showing significant diferences in both survival and event-free survival rates across the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_rir-2025-0020_s_019\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SVI enhances risk stratification and prognosis prediction in CTD-PAH by efectively distinguishing patients at higher risk for adverse outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/rir-2025-0020","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:04:13Z","timestamp":1759590253000},"page":"168-178","source":"Crossref","is-referenced-by-count":1,"title":["Reevaluating risk assessment in connective tissue disease-associated pulmonary arterial hypertension: The prognostic superiority of stroke volume index"],"prefix":"10.1515","volume":"6","author":[{"given":"Qingqing","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Gerontology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine , Nanjing , , China"},{"name":"Department of Rheumatology, The First Affiliated Hospital with Nanjing Medical University , Nanjing , Jiangsu Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huangshu","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital with Nanjing Medical University , Nanjing , Jiangsu Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University , Nanjing , Jiangsu Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University , Nanjing , Jiangsu Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linwei","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University , Nanjing , Jiangsu Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangdi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital with Nanjing Medical University , Nanjing , Jiangsu Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital with Nanjing Medical University , Nanjing , Jiangsu Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Affiliated Wuxi People\u2019s Hospital of Nanjing Medical University , Wuxi , Jiangsu Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital with Nanjing Medical University , Nanjing , Jiangsu Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7943-1572","authenticated-orcid":false,"given":"Fenghong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The Affiliated Wuxi People\u2019s Hospital of Nanjing Medical University , Wuxi , Jiangsu Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3518-7162","authenticated-orcid":false,"given":"Xiaoxuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, The First Affiliated Hospital with Nanjing Medical University , Nanjing , Jiangsu Province , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"2025110514243507598_j_rir-2025-0020_ref_001","doi-asserted-by":"crossref","unstructured":"Johnson S, Sommer N, Cox-Flaherty K, et al. 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