{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:14:46Z","timestamp":1784268886127,"version":"3.55.0"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,4]]},"abstract":"Abstract<\/jats:title>\n \n Background and Objectives<\/jats:title>\n Concomitant septic and crystal-induced arthritis is a rare condition. Failure to diagnose this condition can result in significant harm to the patient. This study aims to investigate the prevalence and characteristics of concomitant septic and crystal-induced arthritis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A retrospective study included patients diagnosed with concomitant septic and crystal-induced arthritis confirmed by positive bacterial culture and intracellular crystals in synovial fluid of the same joint, from January 1, 2015, to July 31 ,2024.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 45 cases were defined as having the prevalence of concomitant septic and crystal-induced arthritis among patients with crystal-induced arthritis of 4% (45\/1116). Demographic characteristics showed male predominance (73.3%) with a mean \u00b1 SD age of 62.8 \u00b1 14.4 years. Acute monoarthritis (66.7%,\n n<\/jats:italic>\n = 30), which primarily affected the knee (68.9%,\n n<\/jats:italic>\n = 31), was the most common presentation. Fever was present in 95.6% of cases. The median synovial white blood cell (WBC) count was 61, 478 cells\/\u03bcL (interquartile range: 33, 600\u2013131, 030). The mean \u00b1 SD C-reactive protein (CRP) level was 215 \u00b1 96.7 mg\/L. Monosodium urate crystals were found in 80% (\n n<\/jats:italic>\n = 36) of the cases. The predominant bacteria were Staphylococcus (48.9%,\n n<\/jats:italic>\n = 22), with Methicillin-sensitive\n Staphylococcus aureus<\/jats:italic>\n (MSSA) being the most common (28.9%,\n n<\/jats:italic>\n = 13), followed by\n Streptococcus dysgalactiae<\/jats:italic>\n (15.6%,\n n<\/jats:italic>\n = 7) and gram-negative bacilli (15.6%,\n n<\/jats:italic>\n = 7). The mortality rate was 15.6% (\n n<\/jats:italic>\n = 7).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The prevalence of concomitant septic and crystal-induced arthritis was 4% among patients with crystal-induced arthritis, especially among those with acute fever and high synovial WBC counts. The chance of concomitant septic and crystal-induced arthritis is very low in cases with synovial WBC < 12,000 cells\/\u03bcL.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/rir-2025-0021","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:04:13Z","timestamp":1759590253000},"page":"179-187","source":"Crossref","is-referenced-by-count":3,"title":["Prevalence and characteristics of concomitant septic and crystal-induced arthritis: A hospital database and literature review"],"prefix":"10.1515","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1703-3402","authenticated-orcid":false,"given":"Kittikorn","family":"Duangkum","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Khon Kaen Hospital, Ministry of Public Health , Khon Kaen , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattawee","family":"Saengmongkonpipat","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Khon Kaen Hospital, Ministry of Public Health , Khon Kaen , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pimchanok","family":"Tantiwong","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Khon Kaen Hospital, Ministry of Public Health , Khon Kaen , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yada","family":"Siriphannon","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Khon Kaen Hospital, Ministry of Public Health , Khon Kaen , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thida","family":"Phungtaharn","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Khon Kaen Hospital, Ministry of Public Health , Khon Kaen , Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"2025110514243516490_j_rir-2025-0021_ref_001","doi-asserted-by":"crossref","unstructured":"Chen-Xu M, Yokose C, Rai SK, et al. 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