{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:40:06Z","timestamp":1762353606437,"version":"build-2065373602"},"reference-count":27,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,4]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n \n To investigate the association between\n HLA-B<\/jats:italic>\n and\n HLA-DR<\/jats:italic>\n gene polymorphisms and rheumatoid arthritis (RA) in Yunnan Han population, China.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 246 RA patients and 259 healthy controls (HCs) were enrolled.\n HLA-B\/DR<\/jats:italic>\n genotyping was performed using high-resolution reverse polymerase chain reaction sequence specific oligonucleotide probe (PCR-SSOP). and serum anti cyclic citrullinated peptide (anti-CCP) antibody and serological indexes were detected.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In RA patients, the allele frequencies of\n HLA-DRB1*04:05:01<\/jats:italic>\n ,\n *04:10:01<\/jats:italic>\n ,\n *10:01:02<\/jats:italic>\n and\n HLA-B*15:01:01G<\/jats:italic>\n ,\n *40:01:01G<\/jats:italic>\n ,\n *40:02:01G<\/jats:italic>\n , and\n *54:01:01G<\/jats:italic>\n were significantly higher than those in the HCs (OR > 1, all\n P<\/jats:italic>\n < 0.05). Conversely, the frequencies of\n HLA-DRB1*07:01:01<\/jats:italic>\n ,\n *14:01:01<\/jats:italic>\n ,\n *15:01:01:01<\/jats:italic>\n and\n HLA-B*15:01:01<\/jats:italic>\n ,\n *15:02:01<\/jats:italic>\n , and\n *38:02:01<\/jats:italic>\n alleles were decreased in RA group (OR < 1, all\n P<\/jats:italic>\n < 0.05). Haplotype analysis showed that the combination of\n HLA-B*15:01\/DRB1*09:01<\/jats:italic>\n ,\n HLA-B*38:02\/DRB1*08:03<\/jats:italic>\n and\n HLA-B*54:01\/DRB1*04:05<\/jats:italic>\n was decreased in RA patients (OR < 1, all\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The susceptibility of RA in Yunnan Han population is closely related to HLA-B\/DR specific alleles and haplotypes.<\/jats:p>\n <\/jats:sec>","DOI":"10.1515\/rir-2025-0022","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T15:04:13Z","timestamp":1759590253000},"page":"188-194","source":"Crossref","is-referenced-by-count":0,"title":["Association of\n HLA-B<\/i>\n and\n HLA-DR<\/i>\n gene polymorphisms with rheumatoid arthritis: A cross-sectional study in Yunnan Chinese Han population"],"prefix":"10.1515","volume":"6","author":[{"given":"Jing","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , China"},{"name":"Department of Rheumatology and Immunology, Qujing Second People\u2019s Hospital , Qujing , Yunnan Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghuang","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruotong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqi","family":"Cheng","sequence":"additional","affiliation":[{"name":"Affiliated Mental Health Center & Hangzhou Seventh People\u2019s Hospital, Zhejiang University School of Medicine , Hangzhou , Zhejiang Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Smolen JS, Aletaha D, McInnes IB. 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