{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:02:33Z","timestamp":1790960553471,"version":"4.1.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p> Background. Systemic sclerosis (Ssc) is an autoimmune disease characterized by cutaneous and visceral fibrosis and its pathogenesis is incompletely understood. T helper cells are key regulators of the immune response and they seem to be involved in Ssc clinical manifestations. The aim of the study is to determine key cytokines secreted by Th1 (IFN-\u03b3), Th2 (IL-6) and Th17 (IL-17) in Ssc patients and correlate them with specific manifestations of Ssc patients.<\/jats:p>\n               <jats:p> Material and methods. 35 consecutive Ssc patients and 20 age and sex matched controls were recruited. Serum IL-17, IFN-\u03b3 and IL-6 were determined using ELISA method.<\/jats:p>\n               <jats:p> Results. Serum IL-17 and IL-6 levels were not significantly different in Ssc patients and controls. Serum IFN-\u03b3 levels were higher in Ssc patients when compared to controls. Higher serum IFN-\u03b3 levels associated with pulmonary hypertension. After adjusting for gender and age, IL-17 levels remained independently associated with some clinical manifestations of Ssc patients (telangiectasia and high activity score of Ssc).<\/jats:p>\n               <jats:p> Conclusion. Th17 and Th1 cell responses are active in Ssc patients as their cytokines associated with higher disease activity scores and pulmonary manifestations. Th17 and Th1 specific activity and homing within Ssc patients still needs to be defined and determined in order to target them as potential future therapeutic targets in Ssc patients.<\/jats:p>","DOI":"10.1515\/rjim-2015-0006","type":"journal-article","created":{"date-parts":[[2015,10,8]],"date-time":"2015-10-08T18:06:25Z","timestamp":1444327585000},"page":"46-51","source":"Crossref","is-referenced-by-count":16,"title":["IL-17, IL-6 and IFN-\u03b3 in systemic sclerosis patients"],"prefix":"10.1515","volume":"53","author":[{"given":"Paul","family":"B\u0103l\u0103nescu","sequence":"first","affiliation":[{"name":"Clinical Immunology Department, \u201cColentina\u201d Clinical Hospital, Bucharest , Romania"},{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy, Bucharest, Romania"},{"name":"Clinical Research Unit RECIF (R\u00e9seau d\u2019 Epid\u00e9miologie Clinique International Francophone), Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"L\u0103daru","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy, Bucharest, Romania"},{"name":"\u201cAlfred Rusescu\u201d Institute for Mother and Child Protection, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"B\u0103l\u0103nescu","sequence":"additional","affiliation":[{"name":"Clinical Immunology Department, \u201cColentina\u201d Clinical Hospital, Bucharest , Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, \u201cColentina\u201d Clinical Hospital, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"B\u0103icu\u015f","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy, Bucharest, Romania"},{"name":"Clinical Research Unit RECIF (R\u00e9seau d\u2019 Epid\u00e9miologie Clinique International Francophone), Bucharest, Romania"},{"name":"Department of Internal Medicine, \u201cColentina\u201d Clinical Hospital, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gh.A.","family":"Dan","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy, Bucharest, Romania"},{"name":"Clinical Research Unit RECIF (R\u00e9seau d\u2019 Epid\u00e9miologie Clinique International Francophone), Bucharest, Romania"},{"name":"Department of Internal Medicine, \u201cColentina\u201d Clinical Hospital, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2015,10,7]]},"container-title":["Romanian Journal Of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/rjim\/53\/1\/article-p46.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/rjim-2015-0006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T09:58:15Z","timestamp":1617703095000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/rjim-2015-0006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,10,7]]},"published-print":{"date-parts":[[2015,3,1]]}},"alternative-id":["10.1515\/rjim-2015-0006"],"URL":"https:\/\/doi.org\/10.1515\/rjim-2015-0006","relation":{},"ISSN":["1220-4749"],"issn-type":[{"value":"1220-4749","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,1]]}}}