{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:41:46Z","timestamp":1790743306444,"version":"4.1.0"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p> Background. Persistent hyperparathyroidism (HPT) with hypercalcemia is prevalent after transplant and is considered a risk factor for progressive bone loss and fractures and vascular calcification, as well as the development of tubulointerstitial calcifications of renal allografts and graft dysfunction. The subtotal parathyroidectomy is the standard treatment, although currently it has been replaced by the calcimimetic cinacalcet.<\/jats:p>\n               <jats:p>Aim. The hypothesis of this study is that subtotal parathyroidectomy is superior to cinacalcet for treatment of persistent secondary parathyroidectomy post renal transplant, with minimal morbidity and significantly it reduces the cost of treatment after transplantation.<\/jats:p>\n               <jats:p>Methods. We report our long-term clinical experience with either cinacalcet or parathyroidectomy in 59 kidney transplant recipients with hyperparathyroidism. Group one included medical treatment with cinacalcet and had 45 patients while parathyroidectomy patients (group 2) were 16 patients with two of them excluded because of surgical failure.<\/jats:p>\n               <jats:p>Results. No difference was found between groups for any parameter. A greater short-term change of calcium and phosphorus homeostasis obtained by surgery than by cinacalcet, and in long term change, no significant difference between the two groups.<\/jats:p>\n               <jats:p>Conclusions: The main findings of this study are that correction of severe hyperparathyroidism was similar in both surgical and cinacalcet groups with the absence of a difference of long-term serum iPTH 1-84 levels between the two groups.<\/jats:p>","DOI":"10.1515\/rjim-2016-0027","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T12:29:18Z","timestamp":1474547358000},"page":"184-189","source":"Crossref","is-referenced-by-count":5,"title":["Cinacalcet versus Parathyroidectomy in the Treatment of Secondary Hyperparathyroidism Post Renal Transplantation"],"prefix":"10.1515","volume":"54","author":[{"given":"Amin R.","family":"Soliman","sequence":"first","affiliation":[{"name":"Internal Medicine and Nephrology Department, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda A.","family":"Maamoun","sequence":"additional","affiliation":[{"name":"Internal Medicine and Nephrology Department, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Internal Medicine and Nephrology Department, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Darwish","sequence":"additional","affiliation":[{"name":"Internal Medicine and Nephrology Department, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esam","family":"Elbanna","sequence":"additional","affiliation":[{"name":"Internal Medicine and Nephrology Department, Cairo University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2016,9,22]]},"reference":[{"key":"2021040609520203894_j_rjim-2016-0027_ref_001_w2aab2b8b7b1b7b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. PERRIN P., CAILLARD S., JAVIER RM., et al. Persistent hyperparathyroidism is a major risk factor for fractures in the five years after kidney transplantation. American Journal of Transplantation. 2013; 13(10): 2653-2663.","DOI":"10.1111\/ajt.12425"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_002_w2aab2b8b7b1b7b1ab1ab2Aa","doi-asserted-by":"crossref","unstructured":"2. MAZZAFERRO S., PASQUALI M., TAGGI F., et al. Progression of coronary artery calcification in renal transplantation and the role of secondary hyperparathyroidism and inflammation. Clinical Journal of the American Society of Nephrology. 2009; 4(3): 685-690.","DOI":"10.2215\/CJN.03930808"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_003_w2aab2b8b7b1b7b1ab1ab3Aa","doi-asserted-by":"crossref","unstructured":"3. GWINNER W., SUPPA S., MENGEL M., et al. Early calcification of renal allografts detected by protocol biopsies: causes and clinical implications. American Journal of Transplantation. 2005; 5(8): 1934-1941.","DOI":"10.1111\/j.1600-6143.2005.00938.x"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_004_w2aab2b8b7b1b7b1ab1ab4Aa","doi-asserted-by":"crossref","unstructured":"4. Cohen JB., Gordon CE., Balk EM., Francis JM., et al. Cinacalcet for the treatment of hyperparathyroidism in kidney transplant recipients: A systematic review and meta-analysis. Transplantation. 2012; 94(10): 1041-1048.","DOI":"10.1097\/TP.0b013e31826c3968"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_005_w2aab2b8b7b1b7b1ab1ab5Aa","doi-asserted-by":"crossref","unstructured":"5. PASCHOALIN RP., TORREGROSA JV., S\u00c1NCHEZ-ESCUREDO A., BARROS X., DUR\u00c1N CE., CAMPISTOL JM., et al Cinacalcet treatment for stable kidney transplantation patients with hypercalcemia due to persistent secondary hyperparathyroidism: a long-term follow-up. Transplantation Proceedings. 2012; 44(9): 2588-2589.","DOI":"10.1016\/j.transproceed.2012.09.049"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_006_w2aab2b8b7b1b7b1ab1ab6Aa","doi-asserted-by":"crossref","unstructured":"6. LINDBERG J.S., CULLETON B., WONG G., et al. Cinacalcet HCl, an oral calcimimetic agent for the treatment of secondary hyperparathyroidism in hemodialysis and peritoneal dialysis: a randomized, double-blind, multicenter study. Journal of the American Society of Nephrology. 2005; 16(3): 800-807.","DOI":"10.1681\/ASN.2004060512"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_007_w2aab2b8b7b1b7b1ab1ab7Aa","doi-asserted-by":"crossref","unstructured":"7. PALMER S.C., NISTOR I., CRAIG J.C., et al. Cinacalcet in patients with chronic kidney disease: a cumulative meta-analysis of randomized controlled trials. PLoS Medicine. 2013; 10(4).","DOI":"10.1371\/journal.pmed.1001436"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_008_w2aab2b8b7b1b7b1ab1ab8Aa","doi-asserted-by":"crossref","unstructured":"8. PASCHOALIN R.P., TORREGROSA J.V., BARROS X., DURAN C.E., CAMPISTOL J.M. et al. Cinacalcet de novo in persistent hypercalcemia after kidney transplantation secondary to hyperparathyroidism: long-term follow-up and effect of withdrawal. Transplantation proceedings. 2012; 44(8): 2376-2378.","DOI":"10.1016\/j.transproceed.2012.07.049"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_009_w2aab2b8b7b1b7b1ab1ab9Aa","doi-asserted-by":"crossref","unstructured":"9. TORREGROSA J.V., MORALES E., DIAZ J.M., et al. Cinacalcet for hypercalcaemic secondary hyperparathyroidism after renal transplantation: a multicentre, retrospective, 3-year study. Nephrology. 2014; 19(2): 84-93.","DOI":"10.1111\/nep.12186"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_010_w2aab2b8b7b1b7b1ab1ac10Aa","doi-asserted-by":"crossref","unstructured":"10. MESSA P., CAFFORIO C., ALFIERI C., et al. Clinical impact of hypercalcemia in kidney transplant. International Journal of Nephrology. 2011; 2011:9.","DOI":"10.4061\/2011\/906832"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_011_w2aab2b8b7b1b7b1ab1ac11Aa","doi-asserted-by":"crossref","unstructured":"11. MUIRHEAD N., ZALTMAN J.S., GILL J.S., et al. Hypercalcemia in renal transplant patients: prevalence and management in Canadian transplant practice. Clinical Transplantation. 2014; 28(2): 161-165.","DOI":"10.1111\/ctr.12291"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_012_w2aab2b8b7b1b7b1ab1ac12Aa","unstructured":"12. TORREGROSA J.V., BARROS X. Management of hypercalcemia after renal transplantation. Nefrologia. 2013; 33(6): 751-757."},{"key":"2021040609520203894_j_rjim-2016-0027_ref_013_w2aab2b8b7b1b7b1ab1ac13Aa","doi-asserted-by":"crossref","unstructured":"13. EVENEPOEL P., CLAES K., KUYPERS D.R., DEBRUYNE F., VANRENTERGHEM Y., et al. Parathyroidectomy after successful kidney transplantation: a single center study. Nephrology Dialysis Transplantation. 2007; 22(6): 1730-1737.","DOI":"10.1093\/ndt\/gfm044"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_014_w2aab2b8b7b1b7b1ab1ac14Aa","doi-asserted-by":"crossref","unstructured":"14. ROJAS E., CARLINI R.G., CLESCA P., et al. The pathogenesis of osteodystrophy after renal transplantation as detected by early alterations in bone remodeling. Kidney International. 2003; 63(5): 1915-1923.","DOI":"10.1046\/j.1523-1755.2003.00938.x"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_015_w2aab2b8b7b1b7b1ab1ac15Aa","doi-asserted-by":"crossref","unstructured":"15. NAGANO N., NEMETH E.F. Functional proteins involved in regulation of intracellular Ca2+ for drug development: the extracellular calcium receptor and an innovative medical approach to control secondary hyperparathyroidism by calcimimetic. Journal of Pharmacological Sciences. 2005; 97(3): 355-360.","DOI":"10.1254\/jphs.FMJ04007X6"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_016_w2aab2b8b7b1b7b1ab1ac16Aa","doi-asserted-by":"crossref","unstructured":"16. LINDBERG J.S., CULLETON B., WONG G., et al. Cinacalcet HCl, an oral calcimimetic agent for the treatment of secondary hyperparathyroidism in hemodialysis and peritoneal dialysis: a randomized, double-blind, multicenter study. Journal of the American Society of Nephrology. 2005; 16(3): 800-807.","DOI":"10.1681\/ASN.2004060512"},{"key":"2021040609520203894_j_rjim-2016-0027_ref_017_w2aab2b8b7b1b7b1ab1ac17Aa","doi-asserted-by":"crossref","unstructured":"17. GUERRA R., SAAVEDRA I.A., FERNANDEZ E.J., et al. Hypercalcemia secondary to persistent hyperparathyroidism in kidney transplant patients: analysis after a year with Cinacalcet. 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