{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T14:37:24Z","timestamp":1720276644202},"reference-count":37,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Background &amp; Aims<\/jats:bold>. Considering the ability of anti-TNF alpha drugs to lower the burden intestinal inflammation in patients with inflammatory bowel disease (IBD), and the similarity between IBD and ankylosing spondylitis (AS) regarding inflammatory intestinal involvement, we aimed to investigate the impact of anti-TNF alpha biologic therapy on subclinical intestinal inflammation in AS patients.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods<\/jats:bold>. Between January 2008 and December 2013, 38 AS patients and 23 controls were enrolled in the study and investigated with small bowel videocapsule endoscopy examination and ileocolonoscopy. Each tertile of the small bowel (proximal, mid and distal) was assessed by calculating the Lewis score based on the image stream.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results<\/jats:bold>. The Lewis scores were significantly higher in the AS group compared to controls (580.9 \u00b1 818 <jats:italic>vs<\/jats:italic>. 81 \u00b1 121, p&lt;0.001). 16 patients (42.1%) were on anti-TNF alpha therapy (Adalimumab (n = 5), Infliximab (n = 5) or Etanercept (n = 6)).31.3% of them used NSAIDs simultaneously, compared with 77.3% of the other patients (p&lt;0.01). Their Lewis scores were lower compared to the other patients for the entire small bowel (306 \u00b1 164 <jats:italic>vs<\/jats:italic>. 790 \u00b1 1038, p = 0.015), its proximal and distal tertiles (238 \u00b1 154 <jats:italic>vs<\/jats:italic>. 560 \u00b1 543, p = 0.021, and 140 \u00b1 189 <jats:italic>vs<\/jats:italic>. 300 \u00b1 220, p = 0.027, respectively). The Lewis score was also lower in patients receiving Adalimumab\/Infliximab compared to those on Etanercept for the entire bowel and its distal tertile (262 \u00b1 165 <jats:italic>vs<\/jats:italic>. 380 \u00b1 148, p = 0.069 and 62 \u00b1 101 <jats:italic>vs<\/jats:italic>. 273 \u00b1 236, p = 0.060, respectively).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusion<\/jats:bold>. Anti-TNF alpha therapy in patients with AS reduces the subclinical intestinal inflammation, but the magnitude seems to depend upon the class anti-TNF alpha agent used (Clinical Trials. gov NCT00768950).<\/jats:p>","DOI":"10.1515\/rjim-2017-0001","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T12:34:05Z","timestamp":1484829245000},"page":"44-52","source":"Crossref","is-referenced-by-count":1,"title":["Different effects of anti-TNF-alpha biologic drugs on the small bowel macroscopic inflammation in patients with ankylosing spondylitis"],"prefix":"10.1515","volume":"55","author":[{"given":"A.","family":"Chitul","sequence":"first","affiliation":[{"name":"Internal Medicine Department, \u201cCarol Davila\u201d University of Medicine, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Voiosu","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, \u201cCarol Davila\u201d University of Medicine, Bucharest, Romania"},{"name":"Gastroenterology Department, \u201cColentina\u201d Clinical Hospital, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u0103d\u0103lina","family":"Marinescu","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, \u201cColentina\u201d Clinical Hospital, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Caraiola","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, \u201cCarol Davila\u201d University of Medicine, Bucharest, Romania"},{"name":"Internal Medicine Department, \u201cColentina\u201d Clinical Hospital, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, \u201cColentina\u201d Clinical Hospital, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgeta Camelia","family":"Badea","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, \u201cCarol Davila\u201d University of Medicine, Bucharest, Romania"},{"name":"Internal Medicine Department, \u201cColentina\u201d Clinical Hospital, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda Ileana","family":"P\u00e2rvu","sequence":"additional","affiliation":[{"name":"Rheumatology Department, \u201cColentina\u201d Clinical Hospital, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. A.","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, \u201cCarol Davila\u201d University of Medicine, Bucharest, Romania"},{"name":"Internal Medicine Department, \u201cColentina\u201d Clinical Hospital, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. R.","family":"Mateescu","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, \u201cCarol Davila\u201d University of Medicine, Bucharest, Romania"},{"name":"Gastroenterology Department, \u201cColentina\u201d Clinical Hospital, Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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