{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:25:14Z","timestamp":1754396714097},"reference-count":23,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Introduction<\/jats:bold>. Heart failure (HF) is characterized by neuroendocrine activation. The cardiac natriuretic hormones, including atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), together with their related pro-peptides (proANP and proBNP) represent a group of peptide hormones produced by the heart. A normal NT-proBNP level has a high negative predictive value for heart failure. The use of NT-proBNP testing is helpful in diagnosing acute HF in the emergency care setting, allowing an early and optimal treatment. The purpose of this study is to assess the prognostic value of NT-proBNP in heart failure in children younger than 3 years old and to establish whether it correlates with the NYHA\/Ross functional class and left ventricle systolic function.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods<\/jats:bold>. We enrolled 24 consecutive children with HF due to congenital heart diseases and dilated cardiomyopathy. The serum levels of NT-proBNP were measured, all patients underwent echocardiography and left ventricle ejection fraction was calculated.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Results<\/jats:bold>. The highest median value of NT-proBNP was recorded in patients with cyanotic heart diseases (248.0 fmol\/mL), p = 0.610. NT-proBNP had a negative correlation with the ejection fraction of the left ventricle: Spearman's rank correlation coefficient was \u22120.165.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions<\/jats:bold>. NT-proBNP levels correlate with the severity of HF in infants and small children younger than 3 years old with heart failure due to congenital heart diseases and dilated cardiomyopathy.<\/jats:p>","DOI":"10.1515\/rjim-2017-0002","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T10:03:40Z","timestamp":1485252220000},"page":"69-74","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of NT-proBNP in children with heart failure younger than 3 years old"],"prefix":"10.1515","volume":"55","author":[{"given":"Daniela","family":"Iacob","sequence":"first","affiliation":[{"name":"\u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj-Napoca , Department of Pediatrics , III rd Pediatric Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Butnariu","sequence":"additional","affiliation":[{"name":"\u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj-Napoca , Department of Pediatrics , III rd Pediatric Clinic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel-Corneliu","family":"Leucu\u0163a","sequence":"additional","affiliation":[{"name":"\u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj-Napoca , Department of Medical Informatics and Biostatistics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Sama\u015fca","sequence":"additional","affiliation":[{"name":"\u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj-Napoca , Department of Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Deleanu","sequence":"additional","affiliation":[{"name":"\u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj-Napoca , Department of Immunology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iulia","family":"Lupan","sequence":"additional","affiliation":[{"name":"\u201cBabe\u015f-Bolyai\u201d University , Cluj-Napoca , Romania ; Department of Molecular Biology and Biotechnology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"2021040609502567366_j_rjim-2017-0002_ref_001_w2aab2b8c11b1b7b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. BUTNARIU A., IANCU M., SAMASCA G., CHIRA M., LUPAN I. Changes in NT-proBNP in young children with congenital heart malformations. LabMedicine 2014; 45:43-47.","DOI":"10.1309\/LMAO4UY90YJQWKKP"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_002_w2aab2b8c11b1b7b1ab1ab2Aa","doi-asserted-by":"crossref","unstructured":"2. PRONTERA C., ZUCCHELLI G.C., VITTORINI S., STORTI S., EMDIN M., CLERICO A. Comparison between analytical performances of polyclonal and monoclonal electrochemiluminescence immunoassays for NT-proBNP. Clin Chim Acta 2009; 400:70-73.","DOI":"10.1016\/j.cca.2008.10.011"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_003_w2aab2b8c11b1b7b1ab1ab3Aa","doi-asserted-by":"crossref","unstructured":"3. ROSS R.D., BOLLINGER R.O., PINSKY W.W. Grading the severity of congestive heart failure in infants. Pediatr Cardiol 1992; 13:72-75.","DOI":"10.1007\/BF00798207"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_004_w2aab2b8c11b1b7b1ab1ab4Aa","doi-asserted-by":"crossref","unstructured":"4. RUSCONI P.G., LUDWIG D.A., RATNASAMY C., MAS R., HARMON W.G., COLAN S.D., et al. Serial measurements of serum NT-proBNP as markers of left ventricular systolic function and remodeling in children with heart failure. Am Heart J 2010; 160:776-783.","DOI":"10.1016\/j.ahj.2010.07.012"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_005_w2aab2b8c11b1b7b1ab1ab5Aa","doi-asserted-by":"crossref","unstructured":"5. RATNASAMY C., KINNAMON D.D., LIPSHULTZ S.E., RUSCONI P. Associations between neurohormonal and inflammatory activation and heart failure in children. Am Heart J 2008; 155:527-533.","DOI":"10.1016\/j.ahj.2007.11.001"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_006_w2aab2b8c11b1b7b1ab1ab6Aa","unstructured":"6. ARQUES S. Contribution of natriuretic peptide testing and Doppler echocardiography at bedside to the diagnosis of acute heart failure. A practical overview. Minerva Cardioangiol 2012; 60:385-394."},{"key":"2021040609502567366_j_rjim-2017-0002_ref_007_w2aab2b8c11b1b7b1ab1ab7Aa","doi-asserted-by":"crossref","unstructured":"7. BUTNARIU A., ZAMFIR M., IANCU M., IACOB D., SAMASCA G., LUPAN I. Systolic and Diastolic Function in Congestive Heart Failure Pediatric Patients. Rom J Intern Med 2016:54:37\u201346.","DOI":"10.1515\/rjim-2016-0004"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_008_w2aab2b8c11b1b7b1ab1ab8Aa","doi-asserted-by":"crossref","unstructured":"8. HINDERLITER A.L., BLUMENTHAL J.A., O\u2019CONNER C., ADAMS K.F., DUPREE C.S., WAUGH R.A., et al. Independent prognostic value of echocardiography and N-terminal pro\u2013B-type natriuretic peptide in patients with heart failure. Am Heart J 2008; 156:1191-1195.","DOI":"10.1016\/j.ahj.2008.07.022"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_009_w2aab2b8c11b1b7b1ab1ab9Aa","unstructured":"9. R CORE TEAM. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria, 2012. ISBN 3-900051-07-0."},{"key":"2021040609502567366_j_rjim-2017-0002_ref_010_w2aab2b8c11b1b7b1ab1ac10Aa","doi-asserted-by":"crossref","unstructured":"10. BAGGISH A.L., VAN KIMMENADE R.R., JANUZZI J.L. The differential diagnosis of an elevated amino-terminal pro-B-type natriuretic peptide level. Am J Cardiol 2008; 101:43-48.","DOI":"10.1016\/j.amjcard.2007.11.019"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_011_w2aab2b8c11b1b7b1ab1ac11Aa","doi-asserted-by":"crossref","unstructured":"11. BAGGISH A.L., VAN KIMMENADE R.R., JANUZZI J.L. Amino-Terminal Pro-B-Type Natriuretic Peptide Testing and Prognosis in Patients with Acute Dyspnea, Including Those with Acute Heart Failure. Am J Cardiol 2008; 101:49A\u201355A.","DOI":"10.1016\/j.amjcard.2007.11.020"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_012_w2aab2b8c11b1b7b1ab1ac12Aa","doi-asserted-by":"crossref","unstructured":"12. SUGIMOTO M., MANABE H., NAKAU K., FURUYA A., OKUSHIMA K., FUJIYASU H., et al. The role of N-terminal pro-B-type natriuretic peptide in the diagnosis of congestive heart failure in children. Correlation with the heart failure score and comparison with B-type natriuretic peptide. Circ J 2010; 74:998-1005.","DOI":"10.1253\/circj.CJ-09-0535"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_013_w2aab2b8c11b1b7b1ab1ac13Aa","doi-asserted-by":"crossref","unstructured":"13. \u015eAHIN M., PORTAKAL O., KARAG\u00d6Z T., HAS\u00c7ELIK G., \u00d6ZKUTLU S. Diagnostic performance of BNP and NT-ProBNP measurements in children with heart failure based on congenital heart defects and cardiomyopathies. Clin Biochem 2010; 43:1278\u20131281.","DOI":"10.1016\/j.clinbiochem.2010.08.002"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_014_w2aab2b8c11b1b7b1ab1ac14Aa","doi-asserted-by":"crossref","unstructured":"14. KANTOR P.F., RUSCONI P., LIPSHULTZ S., MITAL S., WILKINSON J.D., BURCH M. Current applications and future needs for biomarkers in pediatric cardiomyopathy and heart failure: Summary from the Second International Conference on Pediatric Cardiomyopathy. Prog Pediatr Cardiol 2011; 32:11\u201314.","DOI":"10.1016\/j.ppedcard.2011.06.003"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_015_w2aab2b8c11b1b7b1ab1ac15Aa","doi-asserted-by":"crossref","unstructured":"15. WONG D.T., GEORGE K., WILSON J., MANLHIOT C., MCCRINDLE B.W., ADELI K., et al. Effectiveness of serial increases in amino-terminal pro-B-type natriuretic peptide levels to indicate the need for mechanical circulatory support in children with acute decompensated heart failure. Am J Cardiol 2011; 107:573-578.","DOI":"10.1016\/j.amjcard.2010.10.015"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_016_w2aab2b8c11b1b7b1ab1ac16Aa","doi-asserted-by":"crossref","unstructured":"16. SANTHANAKRISHNAN R., CHONG J.P., NG T.P., LING L.H., SIM D., LEONG K.T., et al. Growth differentiation factor 15, ST2, high-sensitivity troponin T, and N-terminal pro brain natriuretic peptide in heart failure with preserved vs. reduced ejection fraction. Eur J Heart Fail. 2012:14:1338-1347.","DOI":"10.1093\/eurjhf\/hfs130"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_017_w2aab2b8c11b1b7b1ab1ac17Aa","doi-asserted-by":"crossref","unstructured":"17. NIETHAMMER M., SIEBER M., VON HAEHLING S., ANKER S.D., MUNZEL T., HORSTICK G., et al. Inflammatory pathways in patients with heart failure and preserved ejection fraction. Int J Cardiol 2008; 129:111\u2013117.","DOI":"10.1016\/j.ijcard.2007.05.061"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_018_w2aab2b8c11b1b7b1ab1ac18Aa","doi-asserted-by":"crossref","unstructured":"18. DE DENUS S., LAVOIE J., DUCHARME A., O'MEARA E., RACINE N., SIROIS M.G., et al. Differences in biomarkers in patients with heart failure with a reduced vs a preserved left ventricular ejection fraction. Can J Cardiol 2012; 28:62-68.","DOI":"10.1016\/j.cjca.2011.09.007"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_019_w2aab2b8c11b1b7b1ab1ac19Aa","doi-asserted-by":"crossref","unstructured":"19. SCHOU M., GUSTAFSSON F., CORELL P., KISTORP C.N., KJAER A., HILDEBRANDT P.R. The relationship between N-terminal pro-brain natriuretic peptide and risk for hospitalization and mortality is curvilinear in patients with chronic heart failure. Am Heart J 2007; 154:123-129.","DOI":"10.1016\/j.ahj.2007.04.002"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_020_w2aab2b8c11b1b7b1ab1ac20Aa","doi-asserted-by":"crossref","unstructured":"20. JANUZZI J.L. The role of natriuretic peptide testing in guiding chronic heart failure management: review of available data and recommendations for use. Arch Cardiovasc Dis 2012; 105:40-50.","DOI":"10.1016\/j.acvd.2011.10.007"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_021_w2aab2b8c11b1b7b1ab1ac21Aa","doi-asserted-by":"crossref","unstructured":"21. CANTINOTTI M., CLERICO A., MURZI M., VITTORINI S., EMDIN M. Clinical relevance of measurement of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide in pediatric cardiology. Clin Chim Acta. 2008; 390:12-22.","DOI":"10.1016\/j.cca.2007.12.020"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_022_w2aab2b8c11b1b7b1ab1ac22Aa","doi-asserted-by":"crossref","unstructured":"22. JOHNS M.C., STEPHENSON C. Amino-terminal Pro-B-type natriuretic peptide testing in neonatal and pediatric patients. Am J Cardiol 2008; 101:76-81.","DOI":"10.1016\/j.amjcard.2007.11.028"},{"key":"2021040609502567366_j_rjim-2017-0002_ref_023_w2aab2b8c11b1b7b1ab1ac23Aa","doi-asserted-by":"crossref","unstructured":"23. LOWENTHAL A., CAMACHO B.V., LOWENTHAL S., NATAL-HERNANDEZ L., LISZEWSKI W., HILLS N.K., et al. Usefulness of B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide as biomarkers for heart failure in young children with single ventricle congenital heart disease. Am J Cardiol 2012; 109:866-872.","DOI":"10.1016\/j.amjcard.2011.10.049"}],"container-title":["Romanian Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/content.sciendo.com\/view\/journals\/rjim\/55\/2\/article-p69.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/rjim-2017-0002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T09:55:49Z","timestamp":1617702949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/rjim-2017-0002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,1]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,6,6]]},"published-print":{"date-parts":[[2017,6,1]]}},"alternative-id":["10.1515\/rjim-2017-0002"],"URL":"https:\/\/doi.org\/10.1515\/rjim-2017-0002","relation":{},"ISSN":["2501-062X"],"issn-type":[{"value":"2501-062X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,1]]}}}