{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T09:28:41Z","timestamp":1656667721164},"reference-count":14,"publisher":"Walter de Gruyter GmbH","issue":"4","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:bold>Background<\/jats:bold>. Gastric neuroendocrine tumors (GI-NETs) are rare lesions, usually discovered incidentally during endoscopy. Based on their pathology, there are 4 types of GI-NETs. Type I are multiple small polypoid lesions with central ulceration located in the gastric body or the fundus, associated with atrophic gastritis usually noninvasive and very rarely metastatic. We report on a rare case of a gastric NET arising from the muscularis propria layer of the pyloric ring.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Case report<\/jats:bold>. We present the case of a 65-year old woman with a history of alcoholic cirrhosis, investigated for melena. Upper endoscopy revealed a 30 mm submucosal pedunculated polypoid lesion located on the pylorus protruding in the duodenum, with normal overlying mucosa, fundic gastric atrophy and multiple small polyps at this level, with no active bleeding. CT scan did not reveal any distant metastases. An ultrasound endoscopy was performed, and a round hypoechoic heterogeneous solitary mass, evolving from the pyloric muscle was described. Considering a 30-mm tumor evolving from the gastric muscle layer in the absence of local invasion and with no distant metastases we decided against an endoscopical resection and we referred the patient to surgery. A laparoscopic wedge resection was performed. The pathology report described a 30\/25 mm welldifferentiated neuroendocrine tumor invasive in the muscularis mucosa (pT3).<\/jats:p>\n               <jats:p>\n                  <jats:bold>Conclusions<\/jats:bold>. Usually, type I neuroendocrine tumors are located in the body or the fundus of the stomach without submucosal invasion. The interesting feature in our case was that the tumor originated from the pylorus, making it an atypical presentation for a neuroendocrine tumor.<\/jats:p>","DOI":"10.1515\/rjim-2017-0029","type":"journal-article","created":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T10:08:01Z","timestamp":1500113281000},"page":"253-256","source":"Crossref","is-referenced-by-count":2,"title":["An atypical type I gastric neuroendocrine tumor"],"prefix":"10.1515","volume":"55","author":[{"given":"Andrada-Viorela","family":"Gheorghe","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, \u201cColentina\u201d Clinical Hospital , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Rimbas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, \u201cColentina\u201d Clinical Hospital , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Octav","family":"Ginghina","sequence":"additional","affiliation":[{"name":"Department of General Surgery, \u201cSfantul Ioan\u201d Hospital , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrada","family":"Spanu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, \u201cSfantul Ioan\u201d Hospital , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodor Alexandru","family":"Voiosu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, \u201cColentina\u201d Clinical Hospital , Bucharest , Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,11,15]]},"reference":[{"key":"2021040609523552982_j_rjim-2017-0029_ref_001_w2aab3b7c10b1b6b1ab1ab1Aa","doi-asserted-by":"crossref","unstructured":"1. LI TT, QIU F, QIAN ZR, WAN J, QI XK, WU BY. Classification, clinicopathologic features and treatment of gastric neuroendocrine tumors. World J Gastroenterol. 2014; 20 (1): 118-25.","DOI":"10.3748\/wjg.v20.i1.118"},{"key":"2021040609523552982_j_rjim-2017-0029_ref_002_w2aab3b7c10b1b6b1ab1ab2Aa","doi-asserted-by":"crossref","unstructured":"2. MODLIN IM, LYE KD, KIDD M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer. 2003; 97:934-59.","DOI":"10.1002\/cncr.11105"},{"key":"2021040609523552982_j_rjim-2017-0029_ref_003_w2aab3b7c10b1b6b1ab1ab3Aa","doi-asserted-by":"crossref","unstructured":"3. HIRAI M, MATSUMOTO K, UEYAMA H, FUKUSHIMA H, MURAKAMI T, et al. A case of neuroendocrine tumor G1 with unique histopathological growth progress. World J Gastrointest Endosc. 2013; 5 (12): 605-9.","DOI":"10.4253\/wjge.v5.i12.605"},{"key":"2021040609523552982_j_rjim-2017-0029_ref_004_w2aab3b7c10b1b6b1ab1ab4Aa","unstructured":"4. KULKE MH, SHAH MH, BENSON AB, BERGSLAND E, BERLIN JD, et al. NCCN Clinical Practice Guidelines in Oncology \u2013 Neuroendocrine Tumors version 2. 2017 March 29."},{"key":"2021040609523552982_j_rjim-2017-0029_ref_005_w2aab3b7c10b1b6b1ab1ab5Aa","unstructured":"5. CHRISTOPOULOS C, PAPAVASSILIOU E. Gastric neuroendocrine tumors: Biology and management. Annals of Gastroenterology. 2005, 18 (2):127-40."},{"key":"2021040609523552982_j_rjim-2017-0029_ref_006_w2aab3b7c10b1b6b1ab1ab6Aa","unstructured":"6. KL\u00d6PPEL G, PERREN A, HEITZ PU. From carcinoids to a biologically and prognostically relevant classification of the neuroendocrine tumours of the gastrointestinal tract and the pancreas. Acta Clin Croat. 2002; 41:285-94."},{"key":"2021040609523552982_j_rjim-2017-0029_ref_007_w2aab3b7c10b1b6b1ab1ab7Aa","unstructured":"7. VAN WEYENBERG SJB, POHL J. Gastric. Neuroendocrine Tumors - Video Journal and Encyclopedia of GI Endoscopy. 2013; 1 (1):176-7."},{"key":"2021040609523552982_j_rjim-2017-0029_ref_008_w2aab3b7c10b1b6b1ab1ab8Aa","doi-asserted-by":"crossref","unstructured":"8. SCHER\u00dcBL H, CADIOT G, JENSEN RT, R\u00d6SCH T, ST\u00d6LZEL U, KL\u00d6PPEL G. Neuroendocrine tumors of the stomach (gastric carcinoids) are on the rise: small tumors, small problems? Endoscopy. 2010; 42 (8):664-71.","DOI":"10.1055\/s-0030-1255564"},{"key":"2021040609523552982_j_rjim-2017-0029_ref_009_w2aab3b7c10b1b6b1ab1ab9Aa","doi-asserted-by":"crossref","unstructured":"9. KUNZ PL, REIDY-LAGUNES D, ANTHONY LB, BERTINO EM, BRENDTRO K, CHAN JA, et al. Consensus guidelines for the management and treatment of neuroendocrine tumors. Pancreas. 2013; 42 (4):557-77.10.1097\/MPA.0b013e31828e34a4","DOI":"10.1097\/MPA.0b013e31828e34a4"},{"key":"2021040609523552982_j_rjim-2017-0029_ref_010_w2aab3b7c10b1b6b1ab1ac10Aa","doi-asserted-by":"crossref","unstructured":"10. BORDI C. Endocrine Tumours of the Stomach. Path. Res. Pract. 1995; 191: 373-80.","DOI":"10.1016\/S0344-0338(11)80891-5"},{"key":"2021040609523552982_j_rjim-2017-0029_ref_011_w2aab3b7c10b1b6b1ab1ac11Aa","doi-asserted-by":"crossref","unstructured":"11. RINDI G, KLOPPEL G. Endocrine Tumors of the Gut and Pancreas Tumor Biology and Classification. Neuroendocrinology 2004; 80 (suppl 1):12-5.","DOI":"10.1159\/000080733"},{"key":"2021040609523552982_j_rjim-2017-0029_ref_012_w2aab3b7c10b1b6b1ab1ac12Aa","doi-asserted-by":"crossref","unstructured":"12. 12 KIM MK. Endoscopic ultrasound in gastroenteropancreatic neuroendocrine tumors. Gut and Liver. 2012; 6 (4):405-10.","DOI":"10.5009\/gnl.2012.6.4.405"},{"key":"2021040609523552982_j_rjim-2017-0029_ref_013_w2aab3b7c10b1b6b1ab1ac13Aa","doi-asserted-by":"crossref","unstructured":"13. KIM HH, KIM GH, KIM JH, CHOI MG, SONG GA, KIM SE. The efficacy of endoscopic submucosal dissection of type I gastric carcinoid tumors compared with conventional endoscopic mucosal resection. Gastroenterol Res Pract. 2014; 2014:253860.","DOI":"10.1155\/2014\/253860"},{"key":"2021040609523552982_j_rjim-2017-0029_ref_014_w2aab3b7c10b1b6b1ab1ac14Aa","doi-asserted-by":"crossref","unstructured":"14. YOSHIKANE H, TSUKAMOTO Y, NIWA Y, GOTO H, HASE S, MIZUTANI K et al. Carcinoid tumors of the gastrointestinal tract: evaluation with endoscopic ultrasonography. Gastrointestinal Endoscopy. 1993; 39 (3):375-83.10.1016\/S0016-5107(93)70109-1","DOI":"10.1016\/S0016-5107(93)70109-1"}],"container-title":["Romanian Journal of Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/content.sciendo.com\/view\/journals\/rjim\/55\/4\/article-p253.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/rjim-2017-0029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T10:06:34Z","timestamp":1617703594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciendo.com\/article\/10.1515\/rjim-2017-0029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,15]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,11,15]]},"published-print":{"date-parts":[[2017,12,1]]}},"alternative-id":["10.1515\/rjim-2017-0029"],"URL":"https:\/\/doi.org\/10.1515\/rjim-2017-0029","relation":{},"ISSN":["2501-062X"],"issn-type":[{"value":"2501-062X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,15]]}}}