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In this review, we focus on mitochondrial and metabolic disturbances affecting both the central nervous system and peripheral cells, including mitochondrial DNA damage, mitochondrial complexes defects, loss of calcium homeostasis and transcriptional deregulation. Glucose abnormalities have also been described in peripheral tissues of HD patients and in HD animal and cellular models. Moreover, there are no effective neuroprotective treatments available in HD. Thus, we briefly discuss the role of creatine and coenzyme Q10 that target mitochondrial dysfunction and impaired bioenergetics and have been previously used in HD clinical trials.<\/jats:p>","DOI":"10.1515\/rns.2011.060","type":"journal-article","created":{"date-parts":[[2011,12,13]],"date-time":"2011-12-13T11:18:18Z","timestamp":1323775098000},"page":"13-28","source":"Crossref","is-referenced-by-count":13,"title":["Mitochondrial and metabolic-based protective strategies in Huntington\u2019s disease: the case of creatine and coenzyme Q"],"prefix":"10.1515","volume":"23","author":[{"given":"Luana","family":"Naia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jo\u00e3o","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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