{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:42:25Z","timestamp":1765294945973,"version":"3.46.0"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_sjpain-2017-0185_s_001\">\n                    <jats:title>Background and aims:<\/jats:title>\n                    <jats:p>Pain caused by infiltrating pancreatic cancer is complex in nature and may therefore be difficult to treat. In addition to conventional analgesics, neurolytic blockade of the coeliac plexus is often recommended. However, different techniques are advocated, and procedures vary, and the results may therefore be difficult to compare. Therefore strong evidence for the effect of this treatment is still lacking, and more studies are encouraged. Our aim was to describe our technique and procedures using a Computer Tomograph (CT) guided procedure with a dorsal approach and present the results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2017-0185_s_002\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The procedures were performed in collaboration between a radiologist and an anaesthesiologist. All patients had advanced pancreatic cancer. The patients were placed in prone position on pillows, awake and monitored. Optimal placement of injection needles was guided by CT, and the radiologist injected a small dose of contrast as a control. When optimal needle position, the anaesthesiologist took over and completed the procedure. At first 40 mg methylprednisolone was injected to prevent inflammation. Thereafter a mixture of 99% ethanol diluted to 50% by ropivacaine 7.5 mg\/mL to a total amount of 20\u201330 mL per needle was slowly injected. Repeated aspiration was performed during injection to avoid intravasal injection. Pain treatment and pain score was recorded and compared before and after the treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2017-0185_s_003\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Eleven procedures in 10 patients were performed. Age 49\u201375, mean 59 years. Median rest life time was 36 days (11\u2013140). Significant reduction of analgesics was observed 1 week after the procedure, and most patients also reported reduction of pain. No serious side effects were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2017-0185_s_004\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>CT guided neurolytic celiac plexus blockade is a safe and effective treatment for intractable pain caused by advanced pancreatic cancer. Not all patients experience a significant effect, but the side effects are minor, and the procedure should therefore be offered patients experiencing intractable cancer related pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/sjpain-2017-0185","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T17:16:54Z","timestamp":1519838214000},"page":"247-251","source":"Crossref","is-referenced-by-count":10,"title":["CT guided neurolytic blockade of the coeliac plexus in patients with advanced and intractably painful pancreatic cancer"],"prefix":"10.1515","volume":"18","author":[{"given":"Jan Henrik","family":"Rosland","sequence":"first","affiliation":[{"name":"Department of Medicine , Haraldsplass Deaconess Hospital , Bergen , Norway"},{"name":"Department of Clinical Medicine , University of Bergen , Bergen , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonn Terje","family":"Geitung","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine , University of Oslo , Oslo , Norway"},{"name":"Department of Radiology , Akershus University Hospital , Oslo , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"2025120909582477405_j_sjpain-2017-0185_ref_001","doi-asserted-by":"crossref","unstructured":"Hameed M, Hameed H, Erdek M. Pain management in pancreatic cancer. Cancers (Basel) 2010;3:43\u201360.","DOI":"10.3390\/cancers3010043"},{"key":"2025120909582477405_j_sjpain-2017-0185_ref_002","doi-asserted-by":"crossref","unstructured":"Erdek MA, Halpert DE, Gonz\u00e1lez Fern\u00e1ndez M, Cohen SP. Assessment of celiac plexus block and neurolysis outcomes and technique in the management of refractory visceral cancer pain. Pain Med 2010;11:92\u2013100.","DOI":"10.1111\/j.1526-4637.2009.00756.x"},{"key":"2025120909582477405_j_sjpain-2017-0185_ref_003","unstructured":"Mercadante S. Clinical approach to visceral cancer pain. In: Pasricha P, Willis W, Gebhart G, editors. Chronic Abdominal and Visceral Pain. New York: Informa Healthcare 2007:301\u201310."},{"key":"2025120909582477405_j_sjpain-2017-0185_ref_004","doi-asserted-by":"crossref","unstructured":"Mercadante S, Klepstad P, Kurita GP, Sj\u00f8gren P, Giarratano A; European Palliative Care Research Collaborative (EPCRC). 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