{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:58:14Z","timestamp":1773201494024,"version":"3.50.1"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_sjpain-2018-0344_s_001\">\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Several pain conditions have been shown to reduce the discriminative abilities of external stimuli. The aim of this study was to investigate how cutaneous sensitization affects the tempo-spatial discrimination for both painful laser stimulation and mechanical stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2018-0344_s_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifteen healthy subjects were presented with two different stimulation paradigms, a continuous line stimulation and a 2-point stimulation. Line stimulations were delivered in two different directions in lengths of 25, 50, 75, and 100 mm. Two-point distances from 0 to 100 mm were tested. The subjects reported the perceived intensity, and either direction (line stimulations) or number of perceived points (2-point stimulations). All stimuli were tested both before and after topical capsaicin (8% concentration) sensitization (30 min).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2018-0344_s_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All mechanical line stimulations were reported correctly before capsaicin and 3 stimulations (out of 240) were reported incorrectly after capsaicin. For the laser line stimulation, the directional discrimination threshold (DDT) was 69.5 mm before capsaicin and 76.3 mm after capsaicin. The 2-point discrimination threshold for laser stimulation was 70.3 mm before capsaicin and 68.0 mm after, for the mechanical stimuli it was 31.5 mm before capsaicin and 31.0 mm after capsaicin. The perceived intensities were increased for the laser line stimulations after capsaicin (linear mixed model (LMM),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and increased with stimulation length (LMM,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). For mechanical stimuli, NRS was increased following capsaicin (LMM,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The intensities for both mechanical and laser 2-point stimuli increased after capsaicin and increased with distance between points (LMM,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2018-0344_s_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings show how cutaneous sensitization appears to affect directional discrimination to a larger extent than the 2-point discrimination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2018-0344_s_005\">\n                    <jats:title>Implications<\/jats:title>\n                    <jats:p>This study is the first to investigate how directional discrimination is altered during sensitization. If such measures can be optimized they may provide a new method to probe the neural mechanisms in pain patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/sjpain-2018-0344","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T05:02:41Z","timestamp":1557464561000},"page":"605-613","source":"Crossref","is-referenced-by-count":9,"title":["Cutaneous nociceptive sensitization affects the directional discrimination \u2013 but not the 2-point discrimination"],"prefix":"10.1515","volume":"19","author":[{"given":"Ken Steffen","family":"Frahm","sequence":"first","affiliation":[{"name":"Integrative Neuroscience group, Center for Neuroplasticity and Pain (CNAP), SMI , Department of Health Science and Technology , Aalborg University , Fredrik Bajersvej 7D3 (Office A2-204) , Aalborg , Denmark , Phone: +45 99 40 98 42"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten Dahl","family":"M\u00f8rch","sequence":"additional","affiliation":[{"name":"Integrative Neuroscience group, Center for Neuroplasticity and Pain (CNAP), SMI , Department of Health Science and Technology , Aalborg University , Aalborg , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole K\u00e6seler","family":"Andersen","sequence":"additional","affiliation":[{"name":"Integrative Neuroscience group, Center for Neuroplasticity and Pain (CNAP), SMI , Department of Health Science and Technology , Aalborg University , Aalborg , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"2025120909555379412_j_sjpain-2018-0344_ref_001","doi-asserted-by":"crossref","unstructured":"Johnson KO, Phillips JR. 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