{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:24:27Z","timestamp":1785338667923,"version":"3.55.0"},"reference-count":75,"publisher":"Walter de Gruyter GmbH","issue":"1","funder":[{"DOI":"10.13039\/501100004621","name":"Neuroscience Research Center of Kerman University of Medical Sciences","doi-asserted-by":"publisher","award":["9466"],"award-info":[{"award-number":["9466"]}],"id":[{"id":"10.13039\/501100004621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012021","name":"Physiology Research Center of Iran University of Medical Science","doi-asserted-by":"publisher","award":["96-01-30-24473"],"award-info":[{"award-number":["96-01-30-24473"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_sjpain-2020-0037_s_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Several clinical and experimental studies reported the anxiety as one of the neuropathic pain comorbidities; however, the mechanisms involved in this comorbidity are incompletely cleared. The current study investigated the consequence of pain induced by peripheral neuropathy on the serotonin (5-HT) level of the CA1 region of the hippocampus, which is known as a potential reason, for anxiety associated with neuropathic pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2020-0037_s_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this manner, 72 male rats were inconstantly subdivided into three experimental groups as follows: control, sham, and chronic constriction injury (CCI). Neuropathic pain was initiated by the CCI of the sciatic nerve, and then, mechanical allodynia, thermal hyperalgesia, and anxiety-like behavior were evaluated using the von Frey filaments, radiant heat, open field test (OFT), and elevated plus maze (EPM) respectively. To investigate the probable mechanisms, the\n                      <jats:italic>in vivo<\/jats:italic>\n                      extracellular levels of 5-HT were assessed by microdialysis and using reverse-phase high-pressure liquid chromatography (HPLC) in the CA1 region of hippocampus on days 16 and 30 post-CCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2020-0037_s_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our data suggested that CCI caused anxiety-like behavior in OFT and EPM test. 5-HT concentration in the CA1 region of the hippocampus significantly (F=43.8, p=0.000) reduced in CCI rats, when the pain threshold was minimum. Nevertheless, these alterations reversed while the pain threshold innate increased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2020-0037_s_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neuropathic pain, initiated by constriction of the sciatic nerve can induce anxiety-like behavior in rats. This effect accompanies the reduction in 5-HT concentration in the CA1 region of the hippocampus. When the pain spontaneously alleviated, 5-HT level increased and anxiety-like behavior relieved.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/sjpain-2020-0037","type":"journal-article","created":{"date-parts":[[2020,9,7]],"date-time":"2020-09-07T09:36:46Z","timestamp":1599471406000},"page":"135-144","source":"Crossref","is-referenced-by-count":9,"title":["The CA1 hippocampal serotonin alterations involved in anxiety-like behavior induced by sciatic nerve injury in rats"],"prefix":"10.1515","volume":"21","author":[{"given":"Sepideh","family":"Saffarpour","sequence":"first","affiliation":[{"name":"Neuroscience Research Center , Neuropharmacology Institute, Kerman University of Medical Sciences , Kerman , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farinaz","family":"Nasirinezhad","sequence":"additional","affiliation":[{"name":"Physiological Research Center, Department of Physiology , Iran University of Medical Sciences , Tehran , Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,9,7]]},"reference":[{"key":"2025120910014081454_j_sjpain-2020-0037_ref_001","doi-asserted-by":"crossref","unstructured":"Bushnell, MC, Ceko, M, Low, LA. Cognitive and emotional control of pain and its disruption in chronic pain. Nat Rev Neurosci 2013;14:502\u201311. https:\/\/doi.org\/10.1038\/nrn3516.","DOI":"10.1038\/nrn3516"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_002","doi-asserted-by":"crossref","unstructured":"Yalcin, I, Barthas, F, Barrot, M. Emotional consequences of neuropathic pain: insight from preclinical studies. Neurosci Biobehav Rev 2014;47:154\u201364. https:\/\/doi.org\/10.1016\/j.neubiorev.2014.08.002.","DOI":"10.1016\/j.neubiorev.2014.08.002"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_003","doi-asserted-by":"crossref","unstructured":"Wright, ME, Rizzolo, D. An update on the pharmacologic management and treatment of neuropathic pain. Jaapa 2017;30:13\u20137. https:\/\/doi.org\/10.1097\/01.jaa.0000512228.23432.f7.","DOI":"10.1097\/01.JAA.0000512228.23432.f7"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_004","doi-asserted-by":"crossref","unstructured":"Panczyk, K, Golda, S, Waszkielewicz, A, Zelaszczyk, D, Gunia-Krzyzak, A, Marona, H. Serotonergic system and its role in epilepsy and neuropathic pain treatment: a review based on receptor ligands. Curr Pharmaceut Des 2015;21:1723\u201340. https:\/\/doi.org\/10.2174\/1381612821666141121114917.","DOI":"10.2174\/1381612821666141121114917"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_005","doi-asserted-by":"crossref","unstructured":"Bannister, K, Dickenson, AH. What do monoamines do in pain modulation? Curr Opin Support Palliat Care 2016;10:143\u20138. https:\/\/doi.org\/10.1097\/spc.0000000000000207.","DOI":"10.1097\/SPC.0000000000000207"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_006","doi-asserted-by":"crossref","unstructured":"Lopez-Alvarez, VM, Puigdomenech, M, Navarro, X, Cobianchi, S. Monoaminergic descending pathways contribute to modulation of neuropathic pain by increasing-intensity treadmill exercise after peripheral nerve injury. Exp Neurol 2018;299:42\u201355. https:\/\/doi.org\/10.1016\/j.expneurol.2017.10.007.","DOI":"10.1016\/j.expneurol.2017.10.007"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_007","doi-asserted-by":"crossref","unstructured":"Avila-Rojas, SH, Velazquez-Lagunas, I, Salinas-Abarca, AB, Barragan-Iglesias, P, Pineda-Farias, JB, Granados-Soto, V. Role of spinal 5-HT5A, and 5-HT1A\/1B\/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats. Brain Res 2015;1622:377\u201385. https:\/\/doi.org\/10.1016\/j.brainres.2015.06.043.","DOI":"10.1016\/j.brainres.2015.06.043"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_008","doi-asserted-by":"crossref","unstructured":"Munoz-Islas, E, Vidal-Cant\u00fa, GC, Bravo-Hern\u00e1ndez, M, Cervantes-Dur\u00e1n, C, Qui\u00f1onez-Bastidas, GN, Pineda-Farias, JB, et al. Spinal 5-HT(5)A receptors mediate 5-HT-induced antinociception in several pain models in rats. Pharmacol Biochem Behav 2014;120:25\u201332. https:\/\/doi.org\/10.1016\/j.pbb.2014.02.001.","DOI":"10.1016\/j.pbb.2014.02.001"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_009","doi-asserted-by":"crossref","unstructured":"Bjorkman, R. Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat. Acta Anaesthesiol Scand Suppl 1995;103:1\u201344. https:\/\/doi.org\/10.1111\/j.1399-6576.1995.tb04249.x.","DOI":"10.1111\/j.1399-6576.1995.tb04249.x"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_010","doi-asserted-by":"crossref","unstructured":"Obata, H. Analgesic mechanisms of antidepressants for neuropathic pain. Int J Mol Sci 2017;18. https:\/\/doi.org\/10.3390\/ijms18112483.","DOI":"10.3390\/ijms18112483"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_011","doi-asserted-by":"crossref","unstructured":"Hayashida, KI, Obata, H. Strategies to treat chronic pain and strengthen impaired descending noradrenergic inhibitory system. Int J Mol Sci 2019;20. https:\/\/doi.org\/10.3390\/ijms20040822.","DOI":"10.3390\/ijms20040822"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_012","doi-asserted-by":"crossref","unstructured":"Kremer, M, Salvat, E, Muller, A, Yalcin, I, Barrot, M. Antidepressants and gabapentinoids in neuropathic pain: mechanistic insights. Neuroscience 2016;338:183\u2013206. https:\/\/doi.org\/10.1016\/j.neuroscience.2016.06.057.","DOI":"10.1016\/j.neuroscience.2016.06.057"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_013","doi-asserted-by":"crossref","unstructured":"Rojo, ML, Rodr\u00edguez-Gaztelumendi, A, Pazos, \u00c1, D\u00edaz, \u00c1. Differential adaptive changes on serotonin and noradrenaline transporters in a rat model of peripheral neuropathic pain. Neurosci Lett 2012;515:181\u20136. https:\/\/doi.org\/10.1016\/j.neulet.2012.03.050.","DOI":"10.1016\/j.neulet.2012.03.050"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_014","doi-asserted-by":"crossref","unstructured":"Zhuo, M. Descending facilitation. Mol Pain 2017;13:1744806917699212.","DOI":"10.1177\/1744806917699212"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_015","doi-asserted-by":"crossref","unstructured":"Heinricher, MM, Tavares, I, Leith, JL, Lumb, BM. Descending control of nociception: specificity, recruitment and plasticity. Brain Res Rev 2009;60:214\u201325. https:\/\/doi.org\/10.1016\/j.brainresrev.2008.12.009.","DOI":"10.1016\/j.brainresrev.2008.12.009"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_016","doi-asserted-by":"crossref","unstructured":"Vahid-Ansari, F, Daigle, M, Manzini, MC, Tanaka, KF, Hen, R, Geddes, SD, et al. Abrogated freud-1\/cc2d1a repression of 5-HT1A autoreceptors induces fluoxetine-resistant anxiety\/depression-like behavior. J Neurosci 2017;37:11967\u201378. https:\/\/doi.org\/10.1523\/jneurosci.1668-17.2017.","DOI":"10.1523\/JNEUROSCI.1668-17.2017"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_017","doi-asserted-by":"crossref","unstructured":"Sheng, J, Liu, S, Wang, Y, Cui, R, Zhang, X. The link between depression and chronic pain: neural mechanisms in the brain. Neural Plast 2017;2017:9724371.","DOI":"10.1155\/2017\/9724371"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_018","doi-asserted-by":"crossref","unstructured":"Simons, LE, Elman, I, Borsook, D. Psychological processing in chronic pain: a neural systems approach. Neurosci Biobehav Rev 2014;39:61\u201378. https:\/\/doi.org\/10.1016\/j.neubiorev.2013.12.006.","DOI":"10.1016\/j.neubiorev.2013.12.006"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_019","doi-asserted-by":"crossref","unstructured":"Sang, K, Bao, C, Xin, Y, Hu, S, Gao, X, Wang, Y, et al. Plastic change of prefrontal cortex mediates anxiety-like behaviors associated with chronic pain in neuropathic rats. Mol Pain 2018;14: https:\/\/doi.org\/10.1177\/1744806918783931.","DOI":"10.1177\/1744806918783931"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_020","doi-asserted-by":"crossref","unstructured":"Descalzi, G, Mitsi, V, Purushothaman, I, Gaspari, S, Avrampou, K, Loh, YH, et al. Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression. Sci Signal 2017;10. https:\/\/doi.org\/10.1126\/scisignal.aaj1549.","DOI":"10.1126\/scisignal.aaj1549"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_021","doi-asserted-by":"crossref","unstructured":"Ong, WY, Stohler, CS, Herr, DR. Role of the prefrontal cortex in pain processing. Mol Neurobiol 2019;56:1137\u201366. https:\/\/doi.org\/10.1007\/s12035-018-1130-9.","DOI":"10.1007\/s12035-018-1130-9"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_022","doi-asserted-by":"crossref","unstructured":"Thompson, JM, Neugebauer, V. Cortico-limbic pain mechanisms. Neurosci Lett 2019;702:15\u201323. https:\/\/doi.org\/10.1016\/j.neulet.2018.11.037.","DOI":"10.1016\/j.neulet.2018.11.037"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_023","doi-asserted-by":"crossref","unstructured":"Fasick, V, Spengler, RN, Samankan, S, Nader, ND, Ignatowski, TA. The hippocampus and TNF: common links between chronic pain and depression. Neurosci Biobehav Rev 2015;53:139\u201359. https:\/\/doi.org\/10.1016\/j.neubiorev.2015.03.014.","DOI":"10.1016\/j.neubiorev.2015.03.014"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_024","doi-asserted-by":"crossref","unstructured":"Saffarpour, S, Shabani, M, Taheripak, G, Esmaeili-Mahani, S, Janzadeh, A, Nasirinezhad, F. The alteration of hippocampal BDNF expression is associated with anxiety-like behavior following the injury to the sciatic nerve. Arch Neurosci 2018;6:e74029.","DOI":"10.5812\/ans.74029"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_025","doi-asserted-by":"crossref","unstructured":"Apkarian, AV, Mutso, AA, Centeno, MV, Kan, L, Wu, M, Levinstein, M, et al. Role of adult hippocampal neurogenesis in persistent pain. Pain 2016;157:418\u201328. https:\/\/doi.org\/10.1097\/j.pain.0000000000000332.","DOI":"10.1097\/j.pain.0000000000000332"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_026","doi-asserted-by":"crossref","unstructured":"Khanna, S, Chang, LS, Jiang, F, Koh, HC. Nociception-driven decreased induction of Fos protein in ventral hippocampus field CA1 of the rat. Brain Res 2004;1004:167\u201376. https:\/\/doi.org\/10.1016\/j.brainres.2004.01.026.","DOI":"10.1016\/j.brainres.2004.01.026"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_027","doi-asserted-by":"crossref","unstructured":"Soleimannejad, E, Semnanian, S, Fathollahi, Y, Naghdi, N. Microinjection of ritanserin into the dorsal hippocampal CA1 and dentate gyrus decrease nociceptive behavior in adult male rat. Behav Brain Res 2006;168:221\u20135. https:\/\/doi.org\/10.1016\/j.bbr.2005.11.011.","DOI":"10.1016\/j.bbr.2005.11.011"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_028","doi-asserted-by":"crossref","unstructured":"Khanna, S, Sinclair, JG. Responses in the CA1 region of the rat hippocampus to a noxious stimulus. Exp Neurol 1992;117:28\u201335. https:\/\/doi.org\/10.1016\/0014-4886(92)90107-2.","DOI":"10.1016\/0014-4886(92)90107-2"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_029","doi-asserted-by":"crossref","unstructured":"Khanna, S, Sinclair, JG. Noxious stimuli produce prolonged changes in the CA1 region of the rat hippocampus. Pain 1989;39:337\u201343. https:\/\/doi.org\/10.1016\/0304-3959(89)90047-x.","DOI":"10.1016\/0304-3959(89)90047-X"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_030","doi-asserted-by":"crossref","unstructured":"Nakamura, H, Katayama, Y, Kawakami, Y. Hippocampal CA1\/subiculum-prefrontal cortical pathways induce plastic changes of nociceptive responses in cingulate and prelimbic areas. BMC Neurosci 2010;11:100. https:\/\/doi.org\/10.1186\/1471-2202-11-100.","DOI":"10.1186\/1471-2202-11-100"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_031","doi-asserted-by":"crossref","unstructured":"Kalman, E, Keay, KA. Different patterns of morphological changes in the hippocampus and dentate gyrus accompany the differential expression of disability following nerve injury. J Anat 2014;225:591\u2013603. https:\/\/doi.org\/10.1111\/joa.12238.","DOI":"10.1111\/joa.12238"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_032","doi-asserted-by":"crossref","unstructured":"You, Z, Zhang, S, Shen, S, Yang, J, Ding, W, Yang, L, et al. Cognitive impairment in a rat model of neuropathic pain: role of hippocampal microtubule stability. Pain 2018;159:1518\u201328. https:\/\/doi.org\/10.1097\/j.pain.0000000000001233.","DOI":"10.1097\/j.pain.0000000000001233"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_033","doi-asserted-by":"crossref","unstructured":"Saffarpour, S, Shaabani, M, Naghdi, N, Farahmandfar, M, Janzadeh, A, Nasirinezhad, F. In vivo evaluation of the hippocampal glutamate, GABA and the BDNF levels associated with spatial memory performance in a rodent model of neuropathic pain. Physiol Behav 2017;175:97\u2013103. https:\/\/doi.org\/10.1016\/j.physbeh.2017.03.025.","DOI":"10.1016\/j.physbeh.2017.03.025"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_034","doi-asserted-by":"crossref","unstructured":"Jiang, X, Yan, Q, Liu, F, Jing, C, Ding, L, Zhang, L, et al. Chronic trans-astaxanthin treatment exerts antihyperalgesic effect and corrects co-morbid depressive like behaviors in mice with chronic pain. Neurosci Lett 2018;662:36\u201343. https:\/\/doi.org\/10.1016\/j.neulet.2017.09.064.","DOI":"10.1016\/j.neulet.2017.09.064"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_035","doi-asserted-by":"crossref","unstructured":"Arai, M, Genda, Y, Ishikawa, M, Shunsuke, T, Okabe, T, Sakamoto, A. The miRNA and mRNA changes in rat hippocampi after chronic constriction injury. Pain Med 2013;14:720\u20139. https:\/\/doi.org\/10.1111\/pme.12066.","DOI":"10.1111\/pme.12066"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_036","doi-asserted-by":"crossref","unstructured":"McKenna, JT, Vertes, RP. Collateral projections from the median raphe nucleus to the medial septum and hippocampus. Brain Res Bull 2001;54:619\u201330. https:\/\/doi.org\/10.1016\/s0361-9230(01)00465-8.","DOI":"10.1016\/S0361-9230(01)00465-8"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_037","doi-asserted-by":"crossref","unstructured":"Wang, S, Yabuki, Y, Matsuo, K, Xu, J, Izumi, H, Sakimura, K, et al. T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice. PLoS One 2018;13:e0206986. https:\/\/doi.org\/10.1371\/journal.pone.0206986.","DOI":"10.1371\/journal.pone.0206986"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_038","doi-asserted-by":"crossref","unstructured":"Soleimannejad, E, Naghdi, N, Khatami, S, Semnanian, S, Fathollahi, Y. Formalin pain increases the concentration of serotonin and its 5-hydroxyindoleacetic acid metabolite in the CA1 region of hippocampus. Daru 2010;18:29\u201334. https:\/\/doi.org\/10.1016\/s1090-3801(06)60224-3.","DOI":"10.1016\/S1090-3801(06)60224-3"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_039","doi-asserted-by":"crossref","unstructured":"File, SE, Kenny, PJ, Cheeta, S. The role of the dorsal hippocampal serotonergic and cholinergic systems in the modulation of anxiety. Pharmacol Biochem Behav 2000;66:65\u201372. https:\/\/doi.org\/10.1016\/s0091-3057(00)00198-2.","DOI":"10.1016\/S0091-3057(00)00198-2"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_040","doi-asserted-by":"crossref","unstructured":"Liu, KC, Guo, Y, Zhang, J, Chen, L, Liu, YW, Lv, SX, et al. Activation and blockade of dorsal hippocampal serotonin 6 receptors regulate anxiety-like behaviors in a unilateral 6-hydroxydopamine rat model of Parkinson\u2019s disease. Neurol Res 2019:1\u201311. https:\/\/doi.org\/10.1080\/01616412.2019.1611204. 31056008.","DOI":"10.1080\/01616412.2019.1611204"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_041","doi-asserted-by":"crossref","unstructured":"Graeff, FG, Guimar\u00e3es, FS, De Andrade, TG, Deakin, JF. Role of 5-HT in stress, anxiety, and depression. Pharmacol Biochem Behav 1996;54:129\u201341. https:\/\/doi.org\/10.1016\/0091-3057(95)02135-3.","DOI":"10.1016\/0091-3057(95)02135-3"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_042","doi-asserted-by":"crossref","unstructured":"Sant\u2019Ana, AB, Vilela-Costa, HH, Vicente, MA, Hernandes, PM, de Andrade, TG, ZangrossiJrH. Role of 5-HT2C receptors of the dorsal hippocampus in the modulation of anxiety- and panic-related defensive responses in rats. Neuropharmacology 2019;148:311\u20139. https:\/\/doi.org\/10.1016\/j.neuropharm.2019.01.026.","DOI":"10.1016\/j.neuropharm.2019.01.026"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_043","doi-asserted-by":"crossref","unstructured":"Overstreet, DH, Commissaris, RC, De La Garza, R, File, SE, Knapp, DJ, Seiden, LS. Involvement of 5-HT1A receptors in animal tests of anxiety and depression: evidence from genetic models. Stress 2003;6:101\u201310. https:\/\/doi.org\/10.1080\/1025389031000111311.","DOI":"10.1080\/1025389031000111311"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_044","doi-asserted-by":"crossref","unstructured":"Matsuo, M, Kataoka, Y, Mataki, S, Kato, Y, Oi, K. Conflict situation increases serotonin release in rat dorsal hippocampus: in vivo study with microdialysis and Vogel test. Neurosci Lett 1996;215:197\u2013200. https:\/\/doi.org\/10.1016\/0304-3940(96)12982-7.","DOI":"10.1016\/0304-3940(96)12982-7"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_045","doi-asserted-by":"crossref","unstructured":"Bennett, GJ, Xie, YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988;33:87\u2013107. https:\/\/doi.org\/10.1016\/0304-3959(88)90209-6.","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_046","doi-asserted-by":"crossref","unstructured":"Chaplan, SR, Bach, FW, Pogrel, JW, Chung, JM, Yaksh, TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 1994;53:55\u201363. https:\/\/doi.org\/10.1016\/0165-0270(94)90144-9.","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_047","doi-asserted-by":"crossref","unstructured":"Dixon, WJ. The up-and-down method for small samples. J Am Stat Assoc 1965;60:967\u201378. https:\/\/doi.org\/10.1080\/01621459.1965.10480843.","DOI":"10.1080\/01621459.1965.10480843"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_048","doi-asserted-by":"crossref","unstructured":"Cheah, M, Fawcett, JW, Andrews, MR. Assessment of thermal pain sensation in rats and mice using the Hargreaves test. Bio Protoc 2017;7. https:\/\/doi.org\/10.21769\/bioprotoc.2506.","DOI":"10.21769\/BioProtoc.2506"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_049","doi-asserted-by":"crossref","unstructured":"Zhao, Z, Loane, DJ, Murray, MG, Stoica, BA, Faden, AI. Comparing the predictive value of multiple cognitive, affective, and motor tasks after rodent traumatic brain injury. J Neurotrauma 2012;29:2475\u201389. https:\/\/doi.org\/10.1089\/neu.2012.2511.","DOI":"10.1089\/neu.2012.2511"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_050","doi-asserted-by":"crossref","unstructured":"Curio, M, Jacone, H, Perrut, J, Pinto, \u00c2C, Filho, VF, Silva, RC. Acute effect of Copaifera reticulata Ducke copaiba oil in rats tested in the elevated plus-maze: an ethological analysis. J Pharm Pharmacol 2009;61:1105\u201310. https:\/\/doi.org\/10.1211\/jpp\/61.08.0015.","DOI":"10.1211\/jpp\/61.08.0015"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_051","doi-asserted-by":"crossref","unstructured":"Singewald, N, Kaehler, S, Hemeida, R, Philippu, A. Release of serotonin in the rat locus coeruleus: effects of cardiovascular, stressful and noxious stimuli. Eur J Neurosci 1997;9:556\u201362. https:\/\/doi.org\/10.1111\/j.1460-9568.1997.tb01632.x.","DOI":"10.1111\/j.1460-9568.1997.tb01632.x"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_052","doi-asserted-by":"crossref","unstructured":"Seibenhener, ML, Wooten, MC. Use of the open field maze to measure locomotor and anxiety-like behavior in mice. JoVE 2015:e52434, PMID: 25742564 PMCID: PMC4354627. https:\/\/doi.org\/10.3791\/52434.10.3791\/52434.","DOI":"10.3791\/52434"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_053","doi-asserted-by":"crossref","unstructured":"Walf, AA, Frye, CA. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc 2007;2:322\u20138. https:\/\/doi.org\/10.1038\/nprot.2007.44.","DOI":"10.1038\/nprot.2007.44"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_054","doi-asserted-by":"crossref","unstructured":"Narita, M, Kaneko, C, Miyoshi, K, Nagumo, Y, Kuzumaki, N, Nakajima, M, et al. Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala. Neuropsychopharmacology 2006;31:739\u201350. https:\/\/doi.org\/10.1038\/sj.npp.1300858.","DOI":"10.1038\/sj.npp.1300858"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_055","doi-asserted-by":"crossref","unstructured":"Wu, Y, Yao, X, Jiang, Y, He, X, Shao, X, Du, J, et al. Pain aversion and anxiety-like behavior occur at different times during the course of chronic inflammatory pain in rats. J Pain Res 2017;10:2585\u201393. https:\/\/doi.org\/10.2147\/jpr.s139679.","DOI":"10.2147\/JPR.S139679"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_056","doi-asserted-by":"crossref","unstructured":"Minami, M. Neuronal mechanisms for pain-induced aversion behavioral studies using a conditioned place aversion test. Int Rev Neurobiol 2009;85:135\u201344. https:\/\/doi.org\/10.1016\/s0074-7742(09)85010-1.","DOI":"10.1016\/S0074-7742(09)85010-1"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_057","doi-asserted-by":"crossref","unstructured":"Yalcin, I, Bohren, Y, Waltisperger, E, Sage-Ciocca, D, Yin, JC, Freund-Mercier, MJ, et al. A time-dependent history of mood disorders in a murine model of neuropathic pain. Biol Psychiatr 2011;70:946\u201353. https:\/\/doi.org\/10.1016\/j.biopsych.2011.07.017.","DOI":"10.1016\/j.biopsych.2011.07.017"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_058","doi-asserted-by":"crossref","unstructured":"Leite-Almeida, H, Pinto-Ribeiro, F, Almeida, A. Animal models for the study of comorbid pain and psychiatric disorders. Mod Trends Pharmacopsychiatr 2015;30:1\u201321. https:\/\/doi.org\/10.1159\/000435929.","DOI":"10.1159\/000435929"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_059","doi-asserted-by":"crossref","unstructured":"Urban, R, Scherrer, G, Goulding, EH, Tecott, LH, Basbaum, AI. Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity. Pain 2011;152:990\u20131000. https:\/\/doi.org\/10.1016\/j.pain.2010.12.003.","DOI":"10.1016\/j.pain.2010.12.003"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_060","doi-asserted-by":"crossref","unstructured":"Llorca-Torralba, M, Mico, JA, Berrocoso, E. Behavioral effects of combined morphine and MK-801 administration to the locus coeruleus of a rat neuropathic pain model. Prog Neuro-Psychopharmacol Biol Psychiatr 2018;84:257\u201366. https:\/\/doi.org\/10.1016\/j.pnpbp.2018.03.007.","DOI":"10.1016\/j.pnpbp.2018.03.007"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_061","doi-asserted-by":"crossref","unstructured":"Alba-Delgado, C, Cebada-Aleu, A, Mico, JA, Berrocoso, E. Comorbid anxiety-like behavior and locus coeruleus impairment in diabetic peripheral neuropathy: a comparative study with the chronic constriction injury model. Prog Neuro-Psychopharmacol Biol Psychiatr 2016;71:45\u201356. https:\/\/doi.org\/10.1016\/j.pnpbp.2016.06.007.","DOI":"10.1016\/j.pnpbp.2016.06.007"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_062","doi-asserted-by":"crossref","unstructured":"Roeska, K, Doods, H, Arndt, K, Treede, RD, Ceci, A. Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin. Pain 2008;139:349\u201357. https:\/\/doi.org\/10.1016\/j.pain.2008.05.003.","DOI":"10.1016\/j.pain.2008.05.003"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_063","doi-asserted-by":"crossref","unstructured":"Karl, F, Cola\u00e7o, MB, Schulte, A, Sommer, C, \u00dc\u00e7eyler, N. Affective and cognitive behavior is not altered by chronic constriction injury in B7-H1 deficient and wildtype mice. BMC Neurosci 2019;20:16. https:\/\/doi.org\/10.1186\/s12868-019-0498-4.","DOI":"10.1186\/s12868-019-0498-4"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_064","doi-asserted-by":"crossref","unstructured":"Attal, N, Filliatreau, G, Perrot, S, Jazat, F, Di Giamberardino, L, Guilbaud, G. Behavioural pain-related disorders and contribution of the saphenous nerve in crush and chronic constriction injury of the rat sciatic nerve. Pain 1994;59:301\u201312. https:\/\/doi.org\/10.1016\/0304-3959(94)90083-3.","DOI":"10.1016\/0304-3959(94)90083-3"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_065","doi-asserted-by":"crossref","unstructured":"Takahashi, A, Kato, K, Makino, J, Shiroishi, T, Koide, T. Multivariate analysis of temporal descriptions of open-field behavior in wild-derived mouse strains. Behav Genet 2006;36:763\u201374. https:\/\/doi.org\/10.1007\/s10519-005-9038-3.","DOI":"10.1007\/s10519-005-9038-3"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_066","doi-asserted-by":"crossref","unstructured":"Feyissa, DD, Aher, YD, Engidawork, E, H\u00f6ger, H, Lubec, G, Korz, V. Individual differences in male rats in a behavioral test battery: a multivariate statistical approach. Front Behav Neurosci 2017;11:26. https:\/\/doi.org\/10.3389\/fnbeh.2017.00026.","DOI":"10.3389\/fnbeh.2017.00026"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_067","doi-asserted-by":"crossref","unstructured":"Bueno-Junior, LS, Leite, JP. Input convergence, synaptic plasticity and functional coupling across hippocampal-prefrontal-thalamic circuits. Front Neural Circ 2018;12:40. https:\/\/doi.org\/10.3389\/fncir.2018.00040.","DOI":"10.3389\/fncir.2018.00040"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_068","doi-asserted-by":"crossref","unstructured":"Jimenez, JC, Su, K, Goldberg, AR, Luna, VM, Biane, JS, Ordek, G, et al. Anxiety cells in a hippocampal-hypothalamic circuit. Neuron 2018;97:670\u201383. https:\/\/doi.org\/10.1016\/j.neuron.2018.01.016.","DOI":"10.1016\/j.neuron.2018.01.016"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_069","doi-asserted-by":"crossref","unstructured":"Tyrtyshnaia, AA, Manzhulo, IV, Sultanov, RM, Ermolenko, EV. Adult hippocampal neurogenesis in neuropathic pain and alkyl glycerol ethers treatment. Acta Histochem 2017;119:812\u201321. https:\/\/doi.org\/10.1016\/j.acthis.2017.10.007.","DOI":"10.1016\/j.acthis.2017.10.007"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_070","doi-asserted-by":"crossref","unstructured":"Lax, NC, Parker, SA, Hilton, EJ, Seliman, Y, Tidgewell, KJ, Kolber, BJ. Cyanobacterial extract with serotonin receptor subtype 7 (5-HT7 R) affinity modulates depression and anxiety-like behavior in mice. Synapse 2018;72:e22059.","DOI":"10.1002\/syn.22059"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_071","doi-asserted-by":"crossref","unstructured":"Lyu, D, Yu, W, Tang, N, Wang, R, Zhao, Z, Xie, F, et al. The mTOR signaling pathway regulates pain-related synaptic plasticity in rat entorhinal-hippocampal pathways. Mol Pain 2013;9:64. https:\/\/doi.org\/10.1186\/1744-8069-9-64.","DOI":"10.1186\/1744-8069-9-64"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_072","doi-asserted-by":"crossref","unstructured":"Cervo, L, Mocaer, E, Bertaglia, A, Samanin, R. Roles of 5-HT(1A) receptors in the dorsal raphe and dorsal hippocampus in anxiety assessed by the behavioral effects of 8-OH-DPAT and S 15535 in a modified Geller-Seifter conflict model. Neuropharmacology 2000;39:1037\u201343. https:\/\/doi.org\/10.1016\/s0028-3908(99)00189-6.","DOI":"10.1016\/S0028-3908(99)00189-6"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_073","doi-asserted-by":"crossref","unstructured":"Mlinar, B, Corradetti, R. Differential modulation of CA1 impulse flow by endogenous serotonin along the hippocampal longitudinal axis. Hippocampus 2018;28:217\u201325. https:\/\/doi.org\/10.1002\/hipo.22825.","DOI":"10.1002\/hipo.22825"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_074","doi-asserted-by":"crossref","unstructured":"Kaufman, J, DeLorenzo, C, Choudhury, S, Parsey, RV. The 5-HT1A receptor in major depressive disorder. Eur Neuropsychopharmacol 2016;26:397\u2013410. https:\/\/doi.org\/10.1016\/j.euroneuro.2015.12.039.","DOI":"10.1016\/j.euroneuro.2015.12.039"},{"key":"2025120910014081454_j_sjpain-2020-0037_ref_075","doi-asserted-by":"crossref","unstructured":"Zuena, AR, Maftei, D, Alem\u00e0, GS, Dal Moro, F, Lattanzi, R, Casolini, P, et al. Multimodal antidepressant vortioxetine causes analgesia in a mouse model of chronic neuropathic pain. Mol Pain 2018;14:1744806918808987.","DOI":"10.1177\/1744806918808987"}],"container-title":["Scandinavian Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/sjpain\/21\/1\/article-p135.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/sjpain-2020-0037\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/sjpain-2020-0037\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T12:26:49Z","timestamp":1765283209000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/sjpain-2020-0037\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,7]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,9,7]]},"published-print":{"date-parts":[[2021,1,27]]}},"alternative-id":["10.1515\/sjpain-2020-0037"],"URL":"https:\/\/doi.org\/10.1515\/sjpain-2020-0037","relation":{},"ISSN":["1877-8860","1877-8879"],"issn-type":[{"value":"1877-8860","type":"print"},{"value":"1877-8879","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,7]]}}}