{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T19:46:00Z","timestamp":1793562360615,"version":"4.5.0"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_sjpain-2020-0087_s_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The prevalence and impact of pain among patients with multiple myeloma (MM) in their everyday life require renewed attention. MM patients\u2019 survival has increased considerably over the last decades and active disease episodes are interrupted by longer periods with disease inactivity. The aim with this study is to explore pain intensity and pain interference with daily activities during periods of stable or inactive MM disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2020-0087_s_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a cross-sectional study from September 2017 to May 2019, self-reliant MM patients in stable disease filled a comprehensive selection of validated questionnaires regarding pain, other symptoms and quality of life, which they experienced in their daily living. Patient reported pain intensity and interference with daily activities were analyzed for associations with several clinical and demographic factors and discussed from a total pain perspective. The two outcomes, pain intensity and pain interfering with daily activities, were analyzed in two age groups (&lt;65 years or\u00a0\u226565 years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2020-0087_s_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 92 participants, 80% experienced pain to interfere with their daily activities (equal in both age groups), and 63% reported moderate to severe pain intensity; (75%\u00a0\u226565 years, and 49% &lt;65 years). Pain intensity was significantly associated with signs of depression (OR 4.0 [95% CI: 1.2\u201313.9]) and age\u00a0\u226565 years (OR 3.3 [95% CI: 1.2\u20139.2]). Pain interfering with daily activities was nearly significantly associated with bone involvement (OR 3.4 [95% CI: 1.0\u201311.6]) and signs of depression (OR 5.9 [95% CI: 1.0\u201336.3]). The patients were bothered with many problems in addition to pain; fatigue (91%), bone involvement (74%), signs of depression (41%), signs of anxiety (32%), comorbidity (29%) and uncertainty in relation to employment or pension (25%). Neuropathic pain was more prevalent in the feet (33% [95% CI: 23%, 43%]) compared with pain in the hands (13% [95% CI: 7%, 22%]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2020-0087_s_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In periods of stable disease, many MM patients continue to live with intense pain interfering with their daily activities. Additional or associated problems are the presence of bone involvement, neuropathic pain, older age, uncertainty in relation to employment or pension, comorbidity, signs of depression, anxiety and fatigue. This highlights the importance of health professionals being receptive to the patients\u2019 experience of pain throughout their trajectories, to assess pain systematically and to interpret this experience from a total pain perspective. While pain problems in relation to diagnosing and treating MM is well known, this study brings the message that even during periods of stable or inactive MM disease, the patients experience pain with a moderate to severe intensity, that interferes with their everyday living. The improved survival and the consequential long trajectories make coherence in the pain treatment even more important for the patients, who may see different professionals in different health care settings for different reasons. The patient group requires a coordinated, holistic patient-centered pain treatment throughout the disease trajectory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/sjpain-2020-0087","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T10:04:37Z","timestamp":1604397877000},"page":"127-134","source":"Crossref","is-referenced-by-count":15,"title":["Everyday living with pain\u00a0\u2013 reported by patients with multiple myeloma"],"prefix":"10.1515","volume":"21","author":[{"given":"Eva","family":"Jespersen","sequence":"first","affiliation":[{"name":"REHPA\u00a0\u2013 The Danish Knowledge Centre for Rehabilitation and Palliative Care, Institute of Clinical Research, University of Southern Odense , Odense , Denmark"},{"name":"Department of Rehabilitation , Odense University Hospital, Institute of Clinical Research, University of Southern Denmark , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene K.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Hematology , Quality of Life Research Center, Odense University Hospital , Odense , Denmark"},{"name":"Department of Internal Medicine and Cardiology , Regional Hospital Viborg , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke F.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy and Physiotherapy , Zealand University Hospital , Odense , Denmark"},{"name":"Department of Hematology , Odense University Hospital , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"OPEN\u00a0\u2013 Open Patient Data Explorative Network, Odense University Hospital, Department of Clinical Research, University of Southern Denmark , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Jarlb\u00e6k","sequence":"additional","affiliation":[{"name":"REHPA\u00a0\u2013 The Danish Knowledge Centre for Rehabilitation and Palliative Care, Institute of Clinical Research, University of Southern Odense , Odense , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"2025120910020501681_j_sjpain-2020-0087_ref_001","doi-asserted-by":"crossref","unstructured":"Boland, E, Eiser, C, Ezaydi, Y, Greenfield, DM, Ahmedzai, SH, Snowden, JA. 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