{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:47:15Z","timestamp":1779310035409,"version":"3.51.4"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_sjpain-2021-0161_s_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Exercise-induced hypoalgesia (EIH) is a decrease in the pain sensitivity after exercise. Individuals with chronic pain show less EIH after one exercise session compared with pain-free individuals possibly due to pain in exercising muscles. The primary aim of this randomized controlled cross-over study was to compare the EIH response at the exercising thigh muscle following exercises performed with painful vs. non-painful muscles. Secondary aims were to explore if a reduced EIH response was confined to the painful muscle, and whether the muscle pain intensity and the EIH responses were negatively associated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2021-0161_s_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In two sessions, 34 pain-free participants received a painful (hypertonic saline, 5.8%) injection and a control (isotonic saline, 0.9%) injection in the right thigh muscle before performing a 3\u00a0min isometric wall squat exercise. Pressure pain thresholds (PPTs) were assessed at both thighs and the left neck\/shoulder at baseline, after injections and after exercise. Pain intensities in the thighs were rated on numerical rating scales (NRS: 0\u201310).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2021-0161_s_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Hypertonic saline induced moderate thigh pain at rest (NRS: 4.6\u00a0\u00b1\u00a02.1) compared to the control injection (NRS: 0.3\u00a0\u00b1\u00a00.4; p&lt;0.001). EIH at the thighs and neck\/shoulder were not different between sessions (Injected thigh: 0\u00a0kPa; 95% CI:\u00a0\u221251 to 52; Contralateral thigh:\u00a0\u22126\u00a0kPa; 95% CI:\u00a0\u221242 to 30; neck\/shoulder: 19\u00a0kPa; 95% CI:\u00a0\u22126 to 44). No significant associations between pain intensity ratings immediately after the Painful injection and EIH responses at any assessment sites were found (right thigh:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      =0.08, 95% CI:\u00a0\u221212.95 to 20.64, p=0.64, left thigh:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      =\u22120.33, 95% CI:\u00a0\u221227.86 to 0.44, p=0.06; neck\/shoulder:\n                      <jats:italic>\u03b2<\/jats:italic>\n                      =\u22120.18, 95% CI:\u00a0\u221215.11 to 4.96, p=0.31).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2021-0161_s_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pain in the area of an exercising muscle did not reduce local or systemic EIH responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2021-0161_s_005\">\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>NCT04354948.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/sjpain-2021-0161","type":"journal-article","created":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T12:10:55Z","timestamp":1640434255000},"page":"614-621","source":"Crossref","is-referenced-by-count":5,"title":["Hypoalgesia after exercises with painful vs. non-painful muscles in healthy subjects\u00a0\u2013 a randomized cross-over study"],"prefix":"10.1515","volume":"22","author":[{"given":"Simon","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Health Science and Technology , SMI, Faculty of Medicine, Aalborg University , Aalborg , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian Kj\u00e6r","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology , SMI, Faculty of Medicine, Aalborg University , Aalborg , Denmark"},{"name":"Department of Health Science and Technology , Center for Neuroplasticity and Pain, Faculty of Medicine, Aalborg University , Aalborg , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Sloth","sequence":"additional","affiliation":[{"name":"School of Physiotherapy, University College Lillebaelt , Odense , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Line Appelon","family":"Manum","sequence":"additional","affiliation":[{"name":"School of Physiotherapy, University College Lillebaelt , Odense , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita Kj\u00e6r","family":"McDonald","sequence":"additional","affiliation":[{"name":"School of Physiotherapy, University College Lillebaelt , Odense , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per Gr\u00fcnwald","family":"Andersen","sequence":"additional","affiliation":[{"name":"Pain Research Group, Pain Center , Odense University Hospital , Odense , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7707-9947","authenticated-orcid":false,"given":"Henrik Bjarke","family":"Vaegter","sequence":"additional","affiliation":[{"name":"Pain Research Group, Pain Center , Odense University Hospital , Odense , Denmark"},{"name":"Department of Clinical Research , Faculty of Health Sciences, University of Southern Denmark , Odense , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2021,12,27]]},"reference":[{"key":"2025120910015055845_j_sjpain-2021-0161_ref_001","doi-asserted-by":"crossref","unstructured":"Pedersen, BK, Saltin, B. 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