{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T21:38:47Z","timestamp":1771105127435,"version":"3.50.1"},"reference-count":30,"publisher":"Walter de Gruyter GmbH","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_sjpain-2021-0217_s_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Treatment for childhood Complex Regional Pain Syndrome (CRPS) is associated with long-term recovery. The present study aimed to investigate the long-term biopsychosocial status and quality of life in young adolescents and adults after the treatment of childhood CRPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2021-0217_s_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A 4\u00a0year follow-up of individuals with childhood-CRPS, type 1 (n=22; age:12\u00a0years (years) [median] at treatment and 17\u00a0years at follow-up) was completed. Biopsychosocial status and quality of life were assessed with structured interviews, using the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), the Strengths and Difficulties Questionnaire (SDQ), the Pediatric Pain Coping Inventory (PPCI), and the Pediatric Quality of Life Inventory (PedsQL). Comparisons were made with normative samples of age-matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2021-0217_s_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CRPS at follow-up was still present in seven out of 22, and non-CRPS pain symptoms were found in 12 out of 22 individuals. Signs of mental health pain-related problems, including phobias and obsessive-compulsive disorder, were observed in ten out of 19 individuals. Mental well-being, social functioning, and quality of life (SDQ and PedsQL) were independent of pain status (p&gt;0.05). Adaptive pain coping strategies were utilized regardless of pain status (PPCI). Social functioning (p&lt;0.01) and the quality of life (p=0.01) were attenuated and statistically significantly poorer than healthy age-matched young adults but better than for fibromyalgia subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2021-0217_s_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A subset of individuals treated for childhood-CRPS, type 1 experiences long-term consequences of persistent pain, a decrease in quality of life indicators, and demonstrates significant psychosocial issues. Childhood-CRPS is suggested to be associated with long-term psychosocial consequences and poorer quality of life than found in age-related healthy peers. Subjects treated for childhood CRPS may need a longer clinical follow-up attempting to preclude relapse of CRPS and non-CRPS pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/sjpain-2021-0217","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T12:53:21Z","timestamp":1654001601000},"page":"473-482","source":"Crossref","is-referenced-by-count":5,"title":["Long-term biopsychosocial issues and health-related quality of life in young adolescents and adults treated for childhood Complex Regional Pain Syndrome, type 1"],"prefix":"10.1515","volume":"22","author":[{"given":"Anne Sofie","family":"Finnmann Munk","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery , Copenhagen University Hospital , Hvidovre , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian Kj\u00e6r","family":"Petersen","sequence":"additional","affiliation":[{"name":"Center for Sensory-Motor Interaction, Translational Biomarkers in Pain and Precision Medicine, Center for Neuroplasticity and Pain, Aalborg University , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"B\u00f8dtker","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery , Copenhagen University Hospital , Hvidovre , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Walther-Larsen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and The Paediatric Pain Clinic , Copenhagen University Hospital , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gitte Bruun","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and The Paediatric Pain Clinic , Copenhagen University Hospital , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Arendt-Nielsen","sequence":"additional","affiliation":[{"name":"Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health Science and Technology, Faculty of Medicine , Aalborg University , Aalborg , Denmark"},{"name":"Department of Medical Gastroenterology, Mech-Sense , Aalborg University Hospital , Aalborg , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery , Copenhagen University Hospital , Hvidovre , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,6,1]]},"reference":[{"key":"2025120910044262133_j_sjpain-2021-0217_ref_001","doi-asserted-by":"crossref","unstructured":"Petersen, PB, Mikkelsen, KL, Lauritzen, JB, Krogsgaard, MR. 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