{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T12:56:54Z","timestamp":1765285014467,"version":"3.46.0"},"reference-count":40,"publisher":"Walter de Gruyter GmbH","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_sjpain-2022-0053_s_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Patients with Korsakoff syndrome (KS) may have a diminished pain perception. Information on KS and pain is scarce and limited to case descriptions. The present study is the first to investigate the underlying neural mechanisms of altered pain perception in patients with KS more systematically.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2022-0053_s_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a literature search on neural correlates of pain perception in other neurocognitive disorders in which extensive research was done.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2022-0053_s_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The brain areas that are affected in KS showed considerable overlap with the neural correlates of pain perception in other neurocognitive disorders. We discussed which different aspects of disturbed pain perception could play a role within KS, based on distinct neural damage and brain areas involved in pain perception.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2022-0053_s_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combining current knowledge, we hypothesize that diminished pain perception in KS may be related to lesioned neural connections between cerebral cortical networks and relays of mainly the thalamus, the periaqueductal gray, and possibly lower brain stem regions projecting to the cerebellum. Based on these neural correlates of altered pain perception, we assume that increased pain thresholds, inhibition of pain signals, and disturbed input to cerebral and cerebellar cortical areas involved in pain processing, all are candidate mechanisms in cases of diminished pain perception in KS. We recommend that clinicians need to be alert for somatic morbidity in patients with KS. Due to altered neural processing of nociceptive input the clinical symptoms of somatic morbidity may present differently (i.e. limited pain responses) and therefore are at risk of being missed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/sjpain-2022-0053","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T23:56:35Z","timestamp":1663545395000},"page":"424-432","source":"Crossref","is-referenced-by-count":2,"title":["Korsakoff syndrome and altered pain perception: a search of underlying neural mechanisms"],"prefix":"10.1515","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6328-4299","authenticated-orcid":false,"given":"Jan W.","family":"Wijnia","sequence":"first","affiliation":[{"name":"Slingedael Center of Expertise for Korsakoff Syndrome , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Oudman","sequence":"additional","affiliation":[{"name":"Slingedael Center of Expertise for Korsakoff Syndrome , Rotterdam , The Netherlands"},{"name":"Experimental Psychology, Helmholtz Institute, Utrecht University , Utrecht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre M.","family":"Batjes","sequence":"additional","affiliation":[{"name":"Slingedael Center of Expertise for Korsakoff Syndrome , Rotterdam , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte A.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Neurology , Maastricht University Medical Center , Maastricht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misha","family":"Oey","sequence":"additional","affiliation":[{"name":"Slingedael Center of Expertise for Korsakoff Syndrome , Rotterdam , The Netherlands"},{"name":"Experimental Psychology, Helmholtz Institute, Utrecht University , Utrecht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Postma","sequence":"additional","affiliation":[{"name":"Slingedael Center of Expertise for Korsakoff Syndrome , Rotterdam , The Netherlands"},{"name":"Experimental Psychology, Helmholtz Institute, Utrecht University , Utrecht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"2025120910050087881_j_sjpain-2022-0053_ref_001","doi-asserted-by":"crossref","unstructured":"Fillingim, RB. Individual differences in pain: understanding the mosaic that makes pain personal. Pain 2017;158(1 Suppl):S11\u2013S18. https:\/\/doi.org\/10.1097\/j.pain.0000000000000775.","DOI":"10.1097\/j.pain.0000000000000775"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_002","doi-asserted-by":"crossref","unstructured":"Hammoud, N, Jimenez-Shahed, J. Chronic neurologic effects of alcohol. Clin Liver Dis 2019;23:141\u201355. https:\/\/doi.org\/10.1016\/j.cld.2018.09.010.","DOI":"10.1016\/j.cld.2018.09.010"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_003","doi-asserted-by":"crossref","unstructured":"Wijnia, JW, Oudman, E, van Gool, WA, Wierdsma, AI, Bresser, EL, Bakker, J, et al.. Severe infections are common in thiamine deficiency and may be related to cognitive outcomes: a cohort study of 68 patients with Wernicke-Korsakoff syndrome. Psychosomatics 2016;57:624\u201333. https:\/\/doi.org\/10.1016\/j.psym.2016.06.004.","DOI":"10.1016\/j.psym.2016.06.004"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_004","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. In: Diagnostic and statistical manual of mental disorders. DSM-5. Arlington, Virginia: American Psychiatric Association; 2013:490\u20131 pp.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_005","doi-asserted-by":"crossref","unstructured":"Kopelman, MD, Thomson, AD, Guerrini, I, Marshall, EJ. The Korsakoff syndrome: clinical aspects, psychology and treatment. Alcohol Alcohol 2009;44:148\u201354. https:\/\/doi.org\/10.1093\/alcalc\/agn118.","DOI":"10.1093\/alcalc\/agn118"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_006","doi-asserted-by":"crossref","unstructured":"Joyce, EM, Robbins, TW. Frontal lobe function in Korsakoff and non-Korsakoff alcoholics: planning and spatial working memory. Neuropsychologia 1991;29:709\u201323. https:\/\/doi.org\/10.1016\/0028-3932(91)90067-i.","DOI":"10.1016\/0028-3932(91)90067-I"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_007","doi-asserted-by":"crossref","unstructured":"Vann, SD, Nelson, AJ. The mammillary bodies and memory: more than a hippocampal relay. Prog Brain Res 2015;219:163\u201385. https:\/\/doi.org\/10.1016\/bs.pbr.2015.03.006.","DOI":"10.1016\/bs.pbr.2015.03.006"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_008","doi-asserted-by":"crossref","unstructured":"Aggleton, JP, Brown, MW. Interleaving brain systems for episodic and recognition memory. Trends Cognit Sci 2006;10:455\u201363. https:\/\/doi.org\/10.1016\/j.tics.2006.08.003.","DOI":"10.1016\/j.tics.2006.08.003"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_009","doi-asserted-by":"crossref","unstructured":"Sullivan, EV, Pfefferbaum, A. Neuroimaging of the Wernicke-Korsakoff syndrome. Alcohol Alcohol 2009;44:155\u201365. https:\/\/doi.org\/10.1093\/alcalc\/agn103.","DOI":"10.1093\/alcalc\/agn103"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_010","unstructured":"Escourolle, R, Poirere, J. Manuel \u00e9l\u00e9mentaire de neuropathology [Synopsis of neuropathology]. Paris: Mason; 1977. Figures\u00a0182 & 183. ISBN 978-2-225-45397-7."},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_011","doi-asserted-by":"crossref","unstructured":"Torvik, A. Two types of brain lesions in Wernicke\u2019s encephalopathy. Neuropathol Appl Neurobiol 1985;11:179\u201390. https:\/\/doi.org\/10.1111\/j.1365-2990.1985.tb00016.x.","DOI":"10.1111\/j.1365-2990.1985.tb00016.x"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_012","doi-asserted-by":"crossref","unstructured":"Wijnia, JW, Goossensen, A. Cerebellar neurocognition and Korsakoff\u2019s syndrome: an hypothesis. 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Neuroanatomy and neuropathology associated with Korsakoff\u2019s syndrome. Neuropsychol Rev 2012;22:72\u201380. https:\/\/doi.org\/10.1007\/s11065-012-9195-0.","DOI":"10.1007\/s11065-012-9195-0"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_034","doi-asserted-by":"crossref","unstructured":"Tracey, I, Ploghaus, A, Gati, JS, Clare, S, Smith, S, Menon, RS, et al.. Imaging attentional modulation of pain in the periaqueductal gray in humans. J Neurosci 2002;22:2748\u201352. https:\/\/doi.org\/10.1523\/JNEUROSCI.22-07-02748.2002.","DOI":"10.1523\/JNEUROSCI.22-07-02748.2002"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_035","doi-asserted-by":"crossref","unstructured":"Fairhurst, M, Wiech, K, Dunckley, P, Tracey, I. Anticipatory brainstem activity predicts neural processing of pain in humans. 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J Neuroimmunol 2020;342:577198. https:\/\/doi.org\/10.1016\/j.jneuroim.2020.577198.","DOI":"10.1016\/j.jneuroim.2020.577198"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_038","doi-asserted-by":"crossref","unstructured":"Diano, M, D\u2019Agata, F, Cauda, F, Costa, T, Geda, E, Sacco, K, et al.. Cerebellar clustering and functional connectivity during pain processing. Cerebellum 2016;15:343\u201356. https:\/\/doi.org\/10.1007\/s12311-015-0706-4.","DOI":"10.1007\/s12311-015-0706-4"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_039","doi-asserted-by":"crossref","unstructured":"Moulton, EA, Schmahmann, JD, Becerra, L, Borsook, D. The cerebellum and pain: passive integrator or active participator? Brain Res Rev 2010;65:14\u201327. https:\/\/doi.org\/10.1016\/j.brainresrev.2010.05.005.","DOI":"10.1016\/j.brainresrev.2010.05.005"},{"key":"2025120910050087881_j_sjpain-2022-0053_ref_040","doi-asserted-by":"crossref","unstructured":"Naser, PV, Kuner, R. 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