{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:42:52Z","timestamp":1765888972051,"version":"3.46.0"},"reference-count":55,"publisher":"Walter de Gruyter GmbH","issue":"2","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Norwegian foundation; Et liv I bevegelse"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_sjpain-2022-0094_s_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Earlier findings suggest that social stress such as abusive supervision may promote pain. In the present study we examine the possible moderating role of\u00a0genetic variability in the\n                      <jats:italic>NRCAM<\/jats:italic>\n                      gene in this process.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2022-0094_s_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The data were collected through a national survey drawn from the National Central Employee Register by Statistics Norway. A total of 1,205 individuals returned both the questionnaire and the saliva kit. Abusive supervision was scored by a 5-item version of the\u00a0Tepper\u2019s 2,000 scale. Headache was measured on a four-category scale; \u2018not bothered,\u2019 \u2018a little bothered,\u2019 \u2018considerably bothered\u2019, \u2018seriously bothered\u2019. Genotyping with regards to NRCAM rs2300043 was carried out using Taqman assay. Ordinal logistic regression was used to analyse the data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2022-0094_s_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For males exposed to abusive supervision, those carrying the rs2300043 CC genotype reported the highest levels of headache. Women showed a trend towards the opposite pattern. Women with the rs2300043 CC genotype seem to have a weaker effect of abusive supervision regarding reported headache than their male counterparts with the CC genotype when exposed to abusive supervision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2022-0094_s_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present results indicated that the association between abusive supervision and headache in men\u00a0with the NRCAM rs2300043 C allele was stronger than\u00a0in other men. This suggests that the NRCAM genotype in men is important for the tolerance of social stress e.g.,\u00a0repeated negative acts from a superior. In contrast, a\u00a0trend, though non-significant, towards the opposite pattern was observed in women. Our result suggests that\u00a0the NRCAM genotype in men manifestly affects stress-induced pain such as headache.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/sjpain-2022-0094","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T15:38:20Z","timestamp":1664638700000},"page":"326-332","source":"Crossref","is-referenced-by-count":3,"title":["Stress-induced headache in the general working population is moderated by the NRCAM rs2300043 genotype"],"prefix":"10.1515","volume":"23","author":[{"given":"Ann-Christin","family":"Sannes","sequence":"first","affiliation":[{"name":"National Institute of Occupational Health , Norway , Oslo , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Olav","family":"Christensen","sequence":"additional","affiliation":[{"name":"National Institute of Occupational Health , Norway , Oslo , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten Birkeland","family":"Nielsen","sequence":"additional","affiliation":[{"name":"National Institute of Occupational Health , Norway , Oslo , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Gjerstad","sequence":"additional","affiliation":[{"name":"National Institute of Occupational Health , Norway , Oslo , Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"2025120910043097131_j_sjpain-2022-0094_ref_001","doi-asserted-by":"crossref","unstructured":"Huang, J, Guo, G, Tang, D, Liu, T, Tan, L. 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