{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:42:07Z","timestamp":1782823327427,"version":"3.54.5"},"reference-count":11,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_sjpain-2023-0069_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To systematically review the existing literature for evidence of efficacy around interventions in the management of persistent pain post radiotherapy for head and neck cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2023-0069_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review of the literature was conducted to assess the effectiveness and safety of interventions for the management of persistent post-radiotherapy pain in head and neck cancers. The primary outcome evaluated whether an intervention resulted in a reduction in pain which was determined using validated pain tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2023-0069_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two randomised controlled trials involving 196 participants fulfilled the inclusion criteria, one evaluating the effect of hypnotherapy and the other evaluating the effect of pregabalin on radiotherapy related pain in head and neck cancer patients. In one study by Thuma et\u00a0al. (2016) there was a decrease in pain scores in the hypnotherapy group (p&lt;0.001). In the other study, by Jiang et\u00a0al. (2018) patients treated with pregabalin had a greater reduction in pain intensity, pain severity and a reduction in pain functional interference (p&lt;0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2023-0069_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of our review suggest that in chronic post-radiotherapy pain for head and neck cancers there is very-low level evidence for the use of hypnotherapy in reducing pain scores and for the use of pregabalin in reducing pain intensity, severity, functional interference and psychological distress with significant improvement in quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/sjpain-2023-0069","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T04:20:43Z","timestamp":1703132443000},"source":"Crossref","is-referenced-by-count":4,"title":["Pain management for persistent pain post radiotherapy in head and neck cancers: systematic review"],"prefix":"10.1515","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7142-8288","authenticated-orcid":false,"given":"Jamie","family":"Young","sequence":"first","affiliation":[{"name":"Peter Mac: Peter MacCallum Cancer Centre , Melbourne , Australia"},{"name":"Department of Critical Care , University of Melbourne , Melbourne , Victoria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Rattan","sequence":"additional","affiliation":[{"name":"Peter Mac: Peter MacCallum Cancer Centre , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Cheung","sequence":"additional","affiliation":[{"name":"Peter Mac: Peter MacCallum Cancer Centre , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smaro","family":"Lazarakis","sequence":"additional","affiliation":[{"name":"Peter Mac: Peter MacCallum Cancer Centre , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"McGilvray","sequence":"additional","affiliation":[{"name":"Peter Mac: Peter MacCallum Cancer Centre , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"2025120910013796580_j_sjpain-2023-0069_ref_001","doi-asserted-by":"crossref","unstructured":"Harris, DJ. Cancer treatment-induced mucositis pain: strategies for\u00a0assessment and management. Ther Clin Risk Manag 2006;2:251\u20138. https:\/\/doi.org\/10.2147\/tcrm.2006.2.3.251.","DOI":"10.2147\/tcrm.2006.2.3.251"},{"key":"2025120910013796580_j_sjpain-2023-0069_ref_002","doi-asserted-by":"crossref","unstructured":"Mirabile, A, Airoldi, C, Ripamonti, C, Bolner, A, Murphy, B, Russi, E, et al.. Pain management in head and neck cancer patients undergoing chemo-radiotherapy: clinical practical recommendations. Crit Rev Oncol Haematol 2016;99:100\u20136. https:\/\/doi.org\/10.1016\/j.critrevonc.2015.11.010.","DOI":"10.1016\/j.critrevonc.2015.11.010"},{"key":"2025120910013796580_j_sjpain-2023-0069_ref_003","doi-asserted-by":"crossref","unstructured":"Elad, S, Zadik, Y. Chronic oral mucositis after radiotherapy to the head and neck: a new insight. Support Care Cancer 2016;24:4825\u201330. https:\/\/doi.org\/10.1007\/s00520-016-3337-5.","DOI":"10.1007\/s00520-016-3337-5"},{"key":"2025120910013796580_j_sjpain-2023-0069_ref_004","doi-asserted-by":"crossref","unstructured":"Kallurkar, A, Kulkarni, S, Delfino, K, Ferraro, D, Rao, K. Characteristics of chronic pain among head and neck cancer patients treated with radiation therapy: a retrospective study. Pain Res Manag 2019;2019:9675654. https:\/\/doi.org\/10.1155\/2019\/9675654.","DOI":"10.1155\/2019\/9675654"},{"key":"2025120910013796580_j_sjpain-2023-0069_ref_005","doi-asserted-by":"crossref","unstructured":"Jiang, J, Li, Y, Shen, Q, Rong, X, Huang, X, Li, H, et al.. Effect of pregabalin on radiotherapy-related neuropathic pain in patients with head and neck cancer: a randomized controlled trial. J Clin Oncol 2019;37:135\u201343. https:\/\/doi.org\/10.1200\/JCO.18.00896.","DOI":"10.1200\/JCO.18.00896"},{"key":"2025120910013796580_j_sjpain-2023-0069_ref_006","doi-asserted-by":"crossref","unstructured":"Kawecki, A, Krajewski, R. Follow-up in patients treated for head and neck cancer. Mag Eur Med Oncol 2014;7:87\u20139. https:\/\/doi.org\/10.1007\/s12254-014-0143-y.","DOI":"10.1007\/s12254-014-0143-y"},{"key":"2025120910013796580_j_sjpain-2023-0069_ref_007","doi-asserted-by":"crossref","unstructured":"Burton, AW, Fanciullo, GJ, Beasley, RD, Fisch, MJ. Chronic pain in the cancer survivor: a new Frontier. Pain Med 2007;8:189\u201398. https:\/\/doi.org\/10.1111\/j.1526-4637.2006.00220.x.","DOI":"10.1111\/j.1526-4637.2006.00220.x"},{"key":"2025120910013796580_j_sjpain-2023-0069_ref_008","doi-asserted-by":"crossref","unstructured":"Chua, KS, Reddy, SK, Lee, MC, Patt, RB. Pain and loss of function in head and neck cancer survivors. J Pain Symptom Manage 1999;18:193\u2013202. https:\/\/doi.org\/10.1016\/s0885-3924(99)00070-6.","DOI":"10.1016\/S0885-3924(99)00070-6"},{"key":"2025120910013796580_j_sjpain-2023-0069_ref_009","doi-asserted-by":"crossref","unstructured":"Epstein, JB, Wilkie, DJ, Fischer, DJ, Kim, YO, Villines, D. Neuropathic and nociceptive pain in head and neck cancer patients receiving radiation therapy. Head Neck Oncol 2009;1:26. https:\/\/doi.org\/10.1186\/1758-3284-1-26.","DOI":"10.1186\/1758-3284-1-26"},{"key":"2025120910013796580_j_sjpain-2023-0069_ref_010","doi-asserted-by":"crossref","unstructured":"Higgins, JPT, Thomas, J, Chandler, J, Cumpston, M, Li, T, Page, M, editors, et al.. Cochrane handbook for systematic reviews of interventions, 2nd ed. Poland: Wiley-Blackwell; 2019.","DOI":"10.1002\/9781119536604"},{"key":"2025120910013796580_j_sjpain-2023-0069_ref_011","unstructured":"Thuma, K, Thannapat, D, Arunpongpaisal, S, Siripul, P. Hypnosis as an adjunct for managing pain in head and neck cancer patients post radiotherapy. J Med Assoc Thai 2016;99:S141\u20137."}],"container-title":["Scandinavian Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/sjpain-2023-0069\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/sjpain-2023-0069\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T12:27:48Z","timestamp":1765283268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/sjpain-2023-0069\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,15]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12,1]]},"published-print":{"date-parts":[[2024,1,26]]}},"alternative-id":["10.1515\/sjpain-2023-0069"],"URL":"https:\/\/doi.org\/10.1515\/sjpain-2023-0069","relation":{},"ISSN":["1877-8860","1877-8879"],"issn-type":[{"value":"1877-8860","type":"print"},{"value":"1877-8879","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,15]]},"article-number":"20230069"}}