{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:26:50Z","timestamp":1783117610324,"version":"3.54.6"},"reference-count":15,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_sjpain-2023-0086_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The rise in opioid prescriptions with a parallel increase in opioid use disorders remains a significant challenge in some developed countries (opioid epidemic). However, little is known about opioid consumption in low- and middle-income countries (LMICs). In this short report, we aim to discuss the increase in opioid consumption in LMICs by providing an update on the opioid perspective in Brazil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2023-0086_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed opioid sales on the publicly available Brazilian Health Regulatory Agency (ANVISA) database from 2015 to 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2023-0086_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In Brazil, opioid sales increased 34.8\u202f%, from 8,839,029 prescriptions in 2015 to 11,913,823 prescriptions in 2020, this represents an increase from 44 to 56 prescriptions for every 1,000 inhabitants. Codeine phosphate combined with paracetamol and tramadol hydrochloride were the most common opioids prescribed with an increase each year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_sjpain-2023-0086_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results suggest that opioid prescriptions are rising in Brazil in a 5 years period. Brazil may have a unique opportunity to learn from other countries and develop consistent policies and guidelines to better educate patients and prescribers and to prevent an opioid crisis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/sjpain-2023-0086","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T04:20:40Z","timestamp":1703132440000},"source":"Crossref","is-referenced-by-count":4,"title":["Are we missing the opioid consumption in low- and middle-income countries?"],"prefix":"10.1515","volume":"24","author":[{"given":"Igor","family":"Correia","sequence":"first","affiliation":[{"name":"Postgraduate Program in Rehabilitation Sciences \u2013 Centro Universit\u00e1rio Augusto Motta (UNISUAM) , Rio de Janeiro , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ney","family":"Meziat-Filho","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Rehabilitation Sciences \u2013 Centro Universit\u00e1rio Augusto Motta (UNISUAM) , Rio de Janeiro , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea D.","family":"Furlan","sequence":"additional","affiliation":[{"name":"KITE , Toronto Rehabilitation Institute, University Health Network , Toronto , Ontario , Canada"},{"name":"Division of Physical Medicine & Rehabilitation, Department of Medicine, Faculty of Medicine , University of Toronto , Toronto , Ontario , Canada"},{"name":"Institute for Work & Health , Toronto , Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Saragiotto","sequence":"additional","affiliation":[{"name":"Masters and Doctoral Programs in Physical Therapy\u00a0\u2013 Universidade Cidade de S\u00e3o Paulo (UNICID) , S\u00e3o Paulo , Brazil"},{"name":"Discipline of Physiotherapy , Graduate School of Health , University of Technology Sydney , Sydney , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9471-1174","authenticated-orcid":false,"given":"Felipe J. J.","family":"Reis","sequence":"additional","affiliation":[{"name":"Physical Therapy Department of Instituto Federal do Rio de Janeiro (IFRJ) , Rio de Janeiro , Brazil"},{"name":"Postgraduation Progam in Clinical Medicine\u00a0\u2013 Universidade Federal do Rio de Janeiro (UFRJ) , Rio de Janeiro , Brazil"},{"name":"Pain in Motion Research Group, Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy , Vrije Universiteit Brussel , Brussels , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"2025120910013822819_j_sjpain-2023-0086_ref_001","doi-asserted-by":"crossref","unstructured":"Volkow, ND, Blanco, C. The changing opioid crisis: development, challenges and opportunities. Mol Psychiatry 2021;26:218\u201333. https:\/\/doi.org\/10.1038\/s41380-020-0661-4.","DOI":"10.1038\/s41380-020-0661-4"},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_002","doi-asserted-by":"crossref","unstructured":"Fischer, B, Pang, M, Tyndall, M. The opioid death crisis in Canada: crucial lessons for public health. Lancet Public Health 2019;4:e81\u20132. https:\/\/doi.org\/10.1016\/s2468-2667(18)30232-9.","DOI":"10.1016\/S2468-2667(18)30232-9"},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_003","doi-asserted-by":"crossref","unstructured":"Compton, WM, Jones, CM, Baldwin, GT. Relationship between nonmedical prescription-opioid use and heroin use. N Engl J Med 2016;374:154\u201363. https:\/\/doi.org\/10.1056\/nejmra1508490.","DOI":"10.1056\/NEJMra1508490"},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_004","doi-asserted-by":"crossref","unstructured":"Florence, C, Luo, F, Rice, K. The economic burden of opioid use disorder and fatal opioid overdose in the United States, 2017. Drug Alcohol Depend 2021;218:108350. https:\/\/doi.org\/10.1016\/j.drugalcdep.2020.108350.","DOI":"10.1016\/j.drugalcdep.2020.108350"},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_005","unstructured":"European Monitoring Centre for Drugs and Drug Addiction. European drug report 2017: trends and developments. Luxembourg: Publications Office of the European Union; 2017."},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_006","unstructured":"Australian Institute of Health and Welfare. Opioid harm in Australia and comparisons between Australia and Canada. Canberra: AIHWcity; 2018:116\u2013p p."},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_007","doi-asserted-by":"crossref","unstructured":"Hastie, BA, Gilson, AM, Maurer, MA, Cleary, JF. An examination of global and regional opioid consumption trends 1980\u20132011. J Pain Palliat Care Pharmacother 2014;28:259\u201375. https:\/\/doi.org\/10.3109\/15360288.2014.941132.","DOI":"10.3109\/15360288.2014.941132"},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_008","doi-asserted-by":"crossref","unstructured":"Cleary, J, Powell, RA, Munene, G, Mwangi-Powell, FN, Luyirika, E, Kiyange, F, et al.. Formulary availability and regulatory barriers to accessibility of opioids for cancer pain in Africa: a report from the Global Opioid Policy Initiative (GOPI). Ann Oncol 2013;24:xi14\u201323. https:\/\/doi.org\/10.1093\/annonc\/mdt499.","DOI":"10.1093\/annonc\/mdt499"},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_009","doi-asserted-by":"crossref","unstructured":"Zin, CS. Ten years of strong opioid analgesics consumption in Malaysia and other Southeast Asian countries. J Pharm BioAllied Sci 2020;12:S846\u20136. https:\/\/doi.org\/10.4103\/jpbs.jpbs_252_19.","DOI":"10.4103\/jpbs.JPBS_252_19"},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_010","doi-asserted-by":"crossref","unstructured":"Krawczyk, N, Greene, MC, Zorzanelli, R, Bastos, FI. Rising trends of prescription opioid sales in contemporary Brazil, 2009-2015. Am J Public Health 2018;108:666\u20138. https:\/\/doi.org\/10.2105\/ajph.2018.304341.","DOI":"10.2105\/AJPH.2018.304341"},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_011","doi-asserted-by":"crossref","unstructured":"Jayawardana, S, Forman, R, Johnston-Webber, C, Campbell, A, Berterame, S, de Joncheere, C, et al.. Global consumption of prescription opioid analgesics between 2009\u20132019: a country-level observational study. EClinicalMedicine 2021;42:101198. https:\/\/doi.org\/10.1016\/j.eclinm.2021.101198.","DOI":"10.1016\/j.eclinm.2021.101198"},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_012","doi-asserted-by":"crossref","unstructured":"M\u00e9graud, F. Time to change approaches to Helicobacter pylori management. Lancet Gastroenterol Hepatol 2017;2:692\u20133. https:\/\/doi.org\/10.1016\/s2468-1253(17)30245-5.","DOI":"10.1016\/S2468-1253(17)30245-5"},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_013","doi-asserted-by":"crossref","unstructured":"Morriss, W, Roques, C. Pain management in low-and middle-income countries. BJA Educ 2018;18:265. https:\/\/doi.org\/10.1016\/j.bjae.2018.05.006.","DOI":"10.1016\/j.bjae.2018.05.006"},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_014","doi-asserted-by":"crossref","unstructured":"Yucum\u00e1, D, Pizarro, AB, Moreno, DA, Mosos, JD, Rinc\u00f3n-Monta\u00f1a, M, Rosselli, D. Opioid use disorders national registries and opioids sales registries: a 10-year prevalence study from a middle-income country. J Opioid Manag 2021;17:383\u20138. https:\/\/doi.org\/10.5055\/jom.2021.0671.","DOI":"10.5055\/jom.2021.0671"},{"key":"2025120910013822819_j_sjpain-2023-0086_ref_015","doi-asserted-by":"crossref","unstructured":"Chisholm-Burns, MA, Spivey, CA, Sherwin, E, Wheeler, J, Hohmeier, K. The opioid crisis: origins, trends, policies, and the roles of pharmacists. Am J Health Syst Pharm 2019;76:424\u201335. https:\/\/doi.org\/10.1093\/ajhp\/zxy089.","DOI":"10.1093\/ajhp\/zxy089"}],"container-title":["Scandinavian Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/sjpain-2023-0086\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/sjpain-2023-0086\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T12:33:08Z","timestamp":1765283588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/sjpain-2023-0086\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,13]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12,1]]},"published-print":{"date-parts":[[2024,1,26]]}},"alternative-id":["10.1515\/sjpain-2023-0086"],"URL":"https:\/\/doi.org\/10.1515\/sjpain-2023-0086","relation":{},"ISSN":["1877-8860","1877-8879"],"issn-type":[{"value":"1877-8860","type":"print"},{"value":"1877-8879","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,13]]},"article-number":"20230086"}}