{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:41:21Z","timestamp":1777948881957,"version":"3.51.4"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"3-4","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004073","name":"Killam Trusts","doi-asserted-by":"publisher","award":["AWD-018101"],"award-info":[{"award-number":["AWD-018101"]}],"id":[{"id":"10.13039\/501100004073","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2019-05204"],"award-info":[{"award-number":["RGPIN-2019-05204"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_teb-2024-0027_abs_001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine how the anti-inflammatory actions of interleukin-10 (IL-10) and IL-6 differ across age and physical activity levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_teb-2024-0027_abs_002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Using a cross-sectional design, fasted blood samples were obtained from younger physically inactive (YI:\u00a0n=10, age: 22.7 \u00b1 3.7\u202fyears, BMI: 24.8 \u00b1 4.8\u202fkg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , &lt;150\u202fmin of weekly moderate-to-vigorous physical activity [MVPA]), younger highly active (YA: n=11 varsity cross country running athletes, 20.7 \u00b1 2.7\u202fyears, 21.1 \u00b1 1.8\u202fkg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , &gt;300\u202fmin of weekly MVPA), and older highly active (OA: 12, 56.0 \u00b1 10.3\u202fyears, 22.8 \u00b1 3.2\u202fkg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , &gt;300\u202fmin of weekly MVPA) individuals and analyzed for leukocyte counts, IL-10 and IL-6-related signaling, and cytokine secretion\n                      <jats:italic>ex vivo.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_teb-2024-0027_abs_003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total white blood cells and monocytes were similar\u00a0between groups (p=0.8) but YA and OA had lower lymphocyte counts than YI (p&lt;0.01). The ability of IL-10 (1\u202fng\/mL) to phosphorylate signal transducer and activator of transcription 3 (STAT3) in CD14 monocytes was greater in YA vs. YI (p&lt;0.03) despite YA having lower IL-10 receptor expression (p&lt;0.01). IL-6 (10\u202fng\/mL) mediated STAT3 phosphorylation in CD4 lymphocytes was higher in OA compared YI (p&lt;0.01), with a similar tendency observed for\u00a0YA vs. YI (p=0.08). Despite enhanced responsiveness of STAT3 to IL-10\/6 in active individuals, the ability of IL-10\/6 to\u00a0inhibit tumor necrosis factor-alpha (TNF-\u237a) secretion from\u00a0lipopolysaccharide-stimulated whole-blood was similar between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_teb-2024-0027_abs_004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Highly active younger and older individuals demonstrate enhanced IL-10- and IL-6-mediated activation of immune cell STAT3. Although the ability of IL-10\/6 to inhibit TNF-\u237a secretion appeared unimpacted by activity level, anti-inflammatory cytokine actions were preserved in older active individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/teb-2024-0027","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T23:40:32Z","timestamp":1731541232000},"page":"255-263","source":"Crossref","is-referenced-by-count":1,"title":["Cross-sectional analysis of blood leukocyte responsiveness to interleukin-10 and interleukin-6 across age and physical activity level"],"prefix":"10.1515","volume":"1","author":[{"given":"Hashim","family":"Islam","sequence":"first","affiliation":[{"name":"School of Health and Exercise Sciences, University of British Columbia Okanagan , Kelowna , BC , Canada"},{"name":"Centre for Chronic Disease Prevention and Management, University of British Columbia Okanagan , Kelowna , BC , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Boultbee","sequence":"additional","affiliation":[{"name":"School of Health and Exercise Sciences, University of British Columbia Okanagan , Kelowna , BC , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garett S.","family":"Jackson","sequence":"additional","affiliation":[{"name":"School of Health and Exercise Sciences, University of British Columbia Okanagan , Kelowna , BC , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice L.","family":"Mui","sequence":"additional","affiliation":[{"name":"Department of Surgery , University of British Columbia , Vancouver , BC , Canada"},{"name":"Department of Biochemistry and Molecular Biology , University of British Columbia , Vancouver , BC , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan P.","family":"Little","sequence":"additional","affiliation":[{"name":"School of Health and Exercise Sciences, University of British Columbia Okanagan , Kelowna , BC , Canada"},{"name":"Centre for Chronic Disease Prevention and Management, University of British Columbia Okanagan , Kelowna , BC , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"2026050314532650784_j_teb-2024-0027_ref_001","doi-asserted-by":"crossref","unstructured":"Furman, D, Campisi, J, Verdin, E, Carrera-Bastos, P, Targ, S, Franceschi, C, et al.. 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