{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:24:24Z","timestamp":1775604264746,"version":"3.50.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Neuropsychiatric deficits can induce marked disability in patients with dementia and increase\ncaregiver distress. Several studies have found that neuropsychiatric symptoms are common both in patients\nwith Alzheimer\u2019s disease (AD) and patients with vascular dementia (VaD). However, there are few studies of the\nneuropsychiatric disturbances in large clinical samples of patients with mixed (cortical - subcortical) VaD from\nmainland China. This study aimed to investigate the neuropsychiatric symptoms in VaD patients in mainland\nChina. Methods: Eighty patients with mixed VaD for over 6 months duration, and their caregivers (VaD group),\nwere recruited for interview in Zhongnan Hospital of Wuhan University, from June 2010 to June 2012. Eighty\nage- and sex-matched normal volunteers (control group) were interviewed at the same time. The Mini Mental\nState Examination (MMSE) and the Neuropsychiatric Inventory (NPI) were administered to the VaD patients, their\ncaregivers, and normal volunteers. Group differences were analyzed using the unpaired t-test. Results: The total\nmean scores of the NPI in the VaD group were higher than in the control group (P &lt; 0.01). The subscale scores of\nNPI, including delusions, hallucinations, depression, apathy, irritability, agitation, aberrant motor behavior, and\nchange in appetite were significantly higher in the VaD group than in the control group (P &lt; 0.05-0.01). Compared\nwith the mild VaD subgroup, the NPI subscale scores of apathy, irritability and total scores were significantly\nhigher in the moderate VaD subgroup (P &lt; 0.05-0.01); the NPI subscale scores of anxiety, apathy, irritability, and\ntotal scores were significantly higher in the severe VaD subgroup (P &lt; 0.01). Compared with the moderate VaD\nsubgroup, the NPI subscale scores of anxiety and apathy were significantly higher in the severe VaD subgroup\n(P &lt; 0.05-0.01). Conclusions: Neuropsychiatric symptoms, such as hallucination, anxiety, apathy, irritability and\naberrant action behavior, are common in patients with mixed VaD from mainland China; anxiety and apathy were\nmore pronounced in the subgroup of severe VaD patients.<\/jats:p>","DOI":"10.1515\/tnsci-2015-0015","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T13:53:55Z","timestamp":1440683635000},"page":"157-161","source":"Crossref","is-referenced-by-count":12,"title":["Neuropsychiatric symptoms\nin patients with vascular\ndementia in mainland China"],"prefix":"10.1515","volume":"6","author":[{"given":"Yan-ling","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Neurology , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"},{"name":"Teaching and research section of Neuropsychiatry , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"},{"name":"Clinical medical research center for dementia and cognitive impairment in Hubei province , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-zhe","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"},{"name":"Teaching and research section of Neuropsychiatry , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Neurology , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"},{"name":"Teaching and research section of Neuropsychiatry , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"},{"name":"Teaching and research section of Neuropsychiatry , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"},{"name":"Teaching and research section of Neuropsychiatry , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"},{"name":"Teaching and research section of Neuropsychiatry , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-yu","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Neurology , Qichun County Renmin Hospital in Hubei province , Qichun 435000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Cao","sequence":"additional","affiliation":[{"name":"Clinical medical research center for dementia and cognitive impairment in Hubei province , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong-hong","family":"Xiong","sequence":"additional","affiliation":[{"name":"Teaching and research section of Neuropsychiatry , Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2015,8,21]]},"container-title":["Translational Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/tnsci\/6\/1\/article-p157.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/tnsci-2015-0015\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/tnsci-2015-0015\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T13:11:27Z","timestamp":1651065087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/tnsci-2015-0015\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,10,26]]},"published-print":{"date-parts":[[2015,1,1]]}},"alternative-id":["10.1515\/tnsci-2015-0015"],"URL":"https:\/\/doi.org\/10.1515\/tnsci-2015-0015","relation":{},"ISSN":["2081-6936"],"issn-type":[{"value":"2081-6936","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}