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PS1 has been implicated in several crucial brain functions including developmental processes, synaptic plasticity, and processing of various molecules, while PS2 has been poorly studied and is considered to be a compensatory partner of PS1. Certain controversial reports have suggested that PS2 has a role in apoptosis, though the underlying mechanism is not clear. To ascertain the role of PS2 in apoptosis, mouse neuroblastoma cells (Neuro2a) were transfected with a cDNA construct encoding full length mouse PS2 and analyzed for viability, expression of PS1, PS2, Bax and p53, Bax protein, and status of chromatin condensation. Our results showed reduced viability, condensed chromatin and higher expression of Bax at mRNA and protein levels, but no change in the expression of p53 and PS1 in PS2-overexpressing Neuro2a cells. Thus, it is evident that PS2, independent of PS1, is associated with apoptosis via a Bax-mediated pathway. These findings might help in the understanding of the involvement of PS2 in apoptosis and its associated brain disorders.<\/jats:p>","DOI":"10.1515\/tnsci-2016-0011","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T07:54:48Z","timestamp":1470210888000},"page":"71-75","source":"Crossref","is-referenced-by-count":8,"title":["Presenilin 2 overexpression is associated with apoptosis in Neuro2a cells"],"prefix":"10.1515","volume":"7","author":[{"given":"Ashish","family":"Kumar","sequence":"first","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, Brain Research Centre, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India"},{"name":"Centre for Genomics, Jiwaji University, Gwalior 474 011, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. M.","family":"Sivanandam","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, Brain Research Centre, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. K.","family":"Thakur","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Molecular Biology, Brain Research Centre, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2016,8,1]]},"reference":[{"key":"2021110909184057681_j_tnsci-2016-0011_ref_001_w2aab3b7c45b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"Marjaux E., Hartmann D., De Strooper B., Presenilins in memory, Alzheimer\u2019s disease, and therapy, Neuron, 2004, 42, 189-192","DOI":"10.1016\/S0896-6273(04)00218-1"},{"key":"2021110909184057681_j_tnsci-2016-0011_ref_002_w2aab3b7c45b1b6b1ab2b1b2Aa","unstructured":"http:\/\/www.alzforum.org\/mutations, accessed on May 14, 2016"},{"key":"2021110909184057681_j_tnsci-2016-0011_ref_003_w2aab3b7c45b1b6b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Laudon H., Winblad B., N\u00e4slund J., The Alzheimer\u2019s disease-associated \u03b3-secretase complex: functional domains in the presenilin 1 protein, Physiol. 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