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Aquaporin 4 (AQP4), is the most abundant water channel in CNS. <jats:italic>AQP4<\/jats:italic> is expressed in astrocytes of the brain, spinal cord, optic nerve and supportive cells in sensory organs. In contrast to MS, immunoreactivity of <jats:italic>AQP4<\/jats:italic> is abolished in NMO lesions. However, conflicting results have been reported regarding the association between <jats:italic>AQP4<\/jats:italic> polymorphisms and demyelinating disorders. Considering the ethnic differences of genetic variations, replications in other cohorts are required. In this study, single nucleotide polymorphisms (SNPs) of <jats:italic>AQP4<\/jats:italic> gene in patients with NMO\/neuromyelitis optica spectrum disorders (NMOSD), and MS in the Northern Han Chinese population were examined. Six selected <jats:italic>AQP4<\/jats:italic> SNPs were genotyped by high-resolution melting (HRM) method. Compared with healthy control (HC), there was no significant difference of <jats:italic>AQP4<\/jats:italic> allele and genotype frequency in MS or NMO\/NMOSD group. This study showed no significant association of common <jats:italic>AQP4<\/jats:italic> SNPs with MS or NMO\/NMOSD, strongly suggesting that polymorphisms of <jats:italic>AQP4<\/jats:italic> gene are unlikely to confer MS or NMO\/NMOSD susceptibility, at least in Northern Han Chinese population.<\/jats:p>","DOI":"10.1515\/tnsci-2016-0012","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T09:49:49Z","timestamp":1471945789000},"page":"76-83","source":"Crossref","is-referenced-by-count":5,"title":["No association of <i>AQP4<\/i> polymorphisms with neuromyelitis optica and multiple sclerosis"],"prefix":"10.1515","volume":"7","author":[{"given":"Ting-Ting","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurology, Beijing Tsinghua Changgung Hospital, Beijing Beijing, 102218, P. R. 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