{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:47:28Z","timestamp":1783396048146,"version":"3.54.6"},"reference-count":53,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"j_tnsci-2018-0004_s_005\"><jats:title id=\"d445264e58297\">Background<\/jats:title><jats:p>Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters.<\/jats:p><\/jats:sec><jats:sec id=\"j_tnsci-2018-0004_s_006\"><jats:title id=\"d445264e58305\">Methods<\/jats:title><jats:p>Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study. Plasma levels of GDF-15 were measured by immunoassay.<\/jats:p><\/jats:sec><jats:sec id=\"j_tnsci-2018-0004_s_007\"><jats:title id=\"d445264e58313\">Results<\/jats:title><jats:p>The levels of GDF-15 were significantly higher (p &lt; 0.001) in patients with BD in comparison with controls. In patients, GDF-15 levels correlated with age (rho = 0.434; p = 0.003) and illness duration (rho = 0.502; p = 0.001).<\/jats:p><\/jats:sec><jats:sec id=\"j_tnsci-2018-0004_s_008\"><jats:title id=\"d445264e58321\">Conclusion<\/jats:title><jats:p>Our findings corroborate the view that BD is an illness associated with accelerated aging.<\/jats:p><\/jats:sec>","DOI":"10.1515\/tnsci-2018-0004","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T22:16:03Z","timestamp":1522016163000},"page":"17-21","source":"Crossref","is-referenced-by-count":27,"title":["Further evidence of accelerated aging in bipolar disorder: Focus on GDF-15"],"prefix":"10.1515","volume":"9","author":[{"given":"Fang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabela G.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica L.","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moises E.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia P.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio L.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref361","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/ana.24506","article-title":"Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders","volume":"78","year":"2015","journal-title":"Ann. 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