{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T17:45:23Z","timestamp":1777139123536,"version":"3.51.4"},"reference-count":77,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_tnsci-2018-0020_s_006\">\n                    <jats:title id=\"d445264e2514\">Background<\/jats:title>\n                    <jats:p>Primary open angle glaucoma (POAG) is the most common form of glaucoma, with a multifactorial etiology that results in retinal ganglion cell death and loss of vision. In this study, we assessed the effects of myricetin on the trabecular meshwork cells in POAG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_tnsci-2018-0020_s_007\">\n                    <jats:title id=\"d445264e2523\">Methods<\/jats:title>\n                    <jats:p>\n                      In the\n                      <jats:italic>in-vivo<\/jats:italic>\n                      model, glaucoma was induced in Sprague-Dawley rats by injecting hyaluronic acid into the anterior chamber of the eye (every week for six-weeks). Treatment group rats were administered myricetin (25, 50 or 100 mg\/ kg body weight via oral gavage) each day for of six weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_tnsci-2018-0020_s_008\">\n                    <jats:title id=\"d445264e2535\">Results<\/jats:title>\n                    <jats:p>POAG TM cells exposed to myricetin (25, 50 or 100 \u03bcM) exhibited significantly lowered reactive oxidative species (ROS) levels and lipid peroxidation products. The expressions of transforming growth factors (TGF\u03b21\/\u03b22), vascular endothelial growth factor, and senescence markers (senescence associated-\u03b2-galactosidase, cyclin-dependent kinase inhibitors-p16 and p21) were substantially down-regulated in POAG TM cells exposed to myricetin. Myricetin effectively prevented IOP elevation in glaucoma-induced rats and decreased inflammatory cytokines (IL-1\u03b1, IL-1\u03b2, IL-6, Il-8, TNF-\u03b1) in the aqueous humor and POAG TM cells of glaucoma-induced rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_tnsci-2018-0020_s_009\">\n                    <jats:title id=\"d445264e2544\">Conclusion<\/jats:title>\n                    <jats:p>The observations of the study illustrate the protective effects of myricetin in glaucomatous TM cells.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/tnsci-2018-0020","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T04:29:25Z","timestamp":1542169765000},"page":"132-141","source":"Crossref","is-referenced-by-count":23,"title":["Effect of myricetin on primary open-angle 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