{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T07:25:55Z","timestamp":1770189955037,"version":"3.49.0"},"reference-count":49,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_tnsci-2020-0010_s_001\">\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Fibrosis in the ventricular system is closely associated with post-hemorrhagic hydrocephalus (PHH). It is characterized by an expansion of the cerebral ventricles due to CSF accumulation following intraventricular hemorrhage (IVH). The activation of transforming growth factor-\u03b21 (TGF-\u03b21) may be involved in thrombin-induced arachnoid fibrosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_tnsci-2020-0010_s_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A rat model of PHH was established by injection of autologous non-anticoagulated blood from the right femoral artery into the lateral ventricles. Differential expression of miR-30a was detected in rat arachnoid cells by RNA sequencing. AP-1, c-Fos, and TRAF3IP2 were knocked down in primary arachnoid cells, and the degree of arachnoid fibrosis was assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_tnsci-2020-0010_s_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Decreased expression of miR-30a and increased expression of TRAF3IP2, TGF-\u03b21, and \u03b1-SMA were detected in the arachnoid cells of PHH rat. Besides, overexpression of miR-30a targets TRAF3IP2 mRNA 3\u2032UTR and inhibits the expression of TRAF3IP2, TGF-\u03b21, and \u03b1-SMA in the primary arachnoid cells. Furthermore, TRAF3IP2 activates AP-1 to promote arachnoid fibrosis. The content of type I collagen in the primary arachnoid cells was reduced after the silencing of AP-1 and TRAF3IP2.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_tnsci-2020-0010_s_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study identified a miR-30a-regulated mechanism of arachnoid fibrosis, suggesting a previously unrecognized contribution of miR-30a to the pathogenesis of fibrosis in the ventricular system. These results might provide a new target for the clinical diagnosis and treatment of PHH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/tnsci-2020-0010","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T08:59:59Z","timestamp":1591088399000},"page":"60-74","source":"Crossref","is-referenced-by-count":20,"title":["Decreased MiR-30a promotes TGF-\u03b21-mediated arachnoid fibrosis in post-hemorrhagic hydrocephalus"],"prefix":"10.1515","volume":"11","author":[{"given":"Chaohong","family":"Zhan","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , P. R. China"},{"name":"Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gelei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , P. R. China"},{"name":"Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , P. R. China"},{"name":"Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , P. R. China"},{"name":"Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , P. R. China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xiangya Hospital, Central South University , Changsha , Hunan 410008 , P. R. 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