{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T14:34:13Z","timestamp":1672670053322},"reference-count":45,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Esophageal achalasia is a primary motility disorder. Although the exact pathogenesis is unknown, autoimmune, and neurodegenerative processes seem to be involved similarly to neurodegenerative and\/or demyelinating disorders (NDDs). We hypothesized that the prevalence of NDD may be higher among patients with achalasia and vice versa as the background pathogenetic mechanisms are similar.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a prospective, comparative questionnaire-based study. Patients with achalasia and patients with NDD were enrolled. Selected patients with achalasia were thoroughly examined by a neurologist and selected patients with NDD were examined by a gastroenterologist to confirm or rule out NDD or achalasia. We assessed the prevalence of both achalasia and NDD and compared them with their prevalence in general population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 150 patients with achalasia and 112 patients with NDD were enrolled. We observed an increased prevalence of NDD among patients with achalasia (6.0% (9\/150); 95% CI (confidence interval): 3.1\u201311.2%) as compared to the estimated 2.0% prevalence in general population (<jats:italic>p<\/jats:italic> = 0.003). Although 32 out of 112 patients (28.6%) with NDD reported dysphagia, we did not observe significantly increased prevalence of achalasia in these patients (1.8% (2\/112) vs 0.8% in general population, <jats:italic>p<\/jats:italic> = 0.226).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The prevalence of NDD was significantly higher among patients with achalasia (6.0%) compared to general population (2.0%), suggesting an association of these disorders. Large-volume studies are necessary to confirm this finding.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/tnsci-2022-0249","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T20:19:55Z","timestamp":1665433195000},"page":"361-368","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of neurodegenerative\/demyelinating disorders in patients with achalasia"],"prefix":"10.1515","volume":"13","author":[{"given":"Martin","family":"Jerie","sequence":"first","affiliation":[{"name":"First Faculty of Medicine, Charles University , 12108 Prague , Czech Republic"},{"name":"Department of Neurology, Na Homolce Hospital , 15000 Prague , Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Vackova","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine , 14021 Prague , Czech Republic"},{"name":"Institute of Physiology, First Faculty of Medicine, Charles University , 12108 Prague , Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdenek","family":"Vojtech","sequence":"additional","affiliation":[{"name":"Department of Neurology, Na Homolce Hospital , 15000 Prague , Czech Republic"},{"name":"Charles University, Third Faculty of Medicine , 10000 Prague , Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Mares","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine , 14021 Prague , Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Meluzinova","sequence":"additional","affiliation":[{"name":"Department of Neurology, Second Faculty of Medicine, Charles University, Motol University Hospital , 15000 Prague , Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Krajciova","sequence":"additional","affiliation":[{"name":"Institute of Physiology, First Faculty of Medicine, Charles University , 12108 Prague , Czech Republic"},{"name":"ResTrial s.r.o. , 16000 Prague , Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Vymazal","sequence":"additional","affiliation":[{"name":"Department of Radiology, Na Homolce Hospital , 15000 Prague , Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Cerna","sequence":"additional","affiliation":[{"name":"Sarkamed s.r.o. , 27401 Slany , Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Martinek","sequence":"additional","affiliation":[{"name":"Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine , 14021 Prague , Czech Republic"},{"name":"Institute of Physiology, First Faculty of Medicine, Charles University , 12108 Prague , Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"2022120618354254737_j_tnsci-2022-0249_ref_001","doi-asserted-by":"crossref","unstructured":"Boeckxstaens GE, Zaninotto G, Richter JE. 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