{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T10:18:30Z","timestamp":1693736310450},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"3-4","license":[{"start":{"date-parts":[[1990,4,1]],"date-time":"1990-04-01T00:00:00Z","timestamp":638928000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p> Chemical and enzymatic procedures are described for the synthesis of the monophosphates and cyclic phosphates of the antiviral acyclonucleoside 9-(1,3-dihydroxy-2-propoxym ethyl)-guanine (DHPG), its 3-hydroxymethyl-4-hydroxybutyl analogue, the (\/?)-and (S)-epimers of 9-(3,4-dihydroxybutyl)guanine, and 9-(2,3-dihydroxypropyl)guanine. <\/jats:p>\n               <jats:p>The structures, and some conformational features, of all the foregoing, were determined by <jats:sup>1<\/jats:sup>H and <jats:sup>31<\/jats:sup>PNMR spectroscopy. Their substrate\/inhibitor properties have been examined in several enzyme systems, including ribonucleases, snake venom phosphodiesterase, beef heart and higher plant cyclic nucleotide phosphodiesterases, nuclease P1, and 3\u2032-and 5\u2032-nucleo-tidases. The enzymatic results are considered in relation to the mechanism of the antiviral ac\u00adtivity of the cyclic phosphate of DHPG .<\/jats:p>","DOI":"10.1515\/znc-1990-3-424","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T17:54:45Z","timestamp":1533232485000},"page":"293-299","source":"Crossref","is-referenced-by-count":7,"title":["Monophosphates and Cyclic Phosphates of Some Antiviral Acyclonucleosides: Synthesis, Conformation and Substrate\/Inhibitor Properties in Some Enzyme Systems"],"prefix":"10.1515","volume":"45","author":[{"given":"Ryszard","family":"Stolarski","sequence":"first","affiliation":[{"name":"Department of Biophysics, Institute of Experimental Physics, University of Warsaw, 02-089 Warszawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslaw M.","family":"Ciesla","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics, Academy of Science, 02-532 Warszawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Shugar","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Institute of Experimental Physics, University of Warsaw, 02-089 Warszawa, Poland"},{"name":"Institute of Biochemistry and Biophysics, Academy of Science, 02-532 Warszawa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,6,2]]},"container-title":["Zeitschrift f\u00fcr Naturforschung C"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/znc.1990.45.issue-3-4\/znc-1990-3-424\/znc-1990-3-424.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-1990-3-424\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-1990-3-424\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T05:09:12Z","timestamp":1667279352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-1990-3-424\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4,1]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2014,6,2]]},"published-print":{"date-parts":[[1990,4,1]]}},"alternative-id":["10.1515\/znc-1990-3-424"],"URL":"https:\/\/doi.org\/10.1515\/znc-1990-3-424","relation":{},"ISSN":["1865-7125","0939-5075"],"issn-type":[{"value":"1865-7125","type":"electronic"},{"value":"0939-5075","type":"print"}],"subject":[],"published":{"date-parts":[[1990,4,1]]}}}