{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T22:13:23Z","timestamp":1771971203005,"version":"3.50.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"3-4","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p> Reactive oxygen species such as OH\u00b7, peroxynitrite and the non-radical, hypochlorous acid, play outstanding roles in many diseases. The formation of OH\u00b7(Fenton-)-type radicals is catalyzed by enzymes such as xanthine oxidase (XOD) via one-electron reduction of mo\u00adlecular oxygen producing superoxide radical anions (O<jats:sub>2<\/jats:sub>\u00b7<jats:sup>-<\/jats:sup>). Subsequent transfer of one elec\u00ad tron to hydrogen peroxide by Fe<jats:sup>2+<\/jats:sup> or Cu<jats:sup>+<\/jats:sup>-ions yields OH-radicals measurable as ethene release from 1-keto-4 methylthiobutyrate (KMB). Xanthine oxidase or activated neutrophils are prominent sources of this strong oxidant produced at inflammatory sites. Many natural compounds such as salicylates or flavonoids interfere either with the pro\u00ad duction of these activated oxygen species or function as radical scavengers and thus as antiox\u00ad idants. Extracts from willow-bark (Salix spec.) and also other species such as ash-tree (Fraxi-nus spec.) or poplar (Populus spec.) have been used as antiinflammatory drugs since a long time. In this communication we wish to report on model reactions to demonstrate a) the radical scavenging activities of such plant extracts inhibiting ethene release from KMB induced by Fenton-type oxidants and b) the inhibition of the formation of nitrogen monoxide (NO) from hydroxylamine includ\u00ading XOD either in the presence or absence of myoglobin (MYO) measurable as nitrite forma\u00adtion: In the absence of MYO, superoxide dismutase is an excellent inhibitor of nitrite forma\u00adtion but is inactive in its presence. Extracts from the willow-bark or the drug Phytodolor<jats:sup>R<\/jats:sup>, however, are inhibitory both in the presence and absence of MYO. As active principle, the flavonoid rutin included in these extracts is likely to function as one inhibitor of the XOD-mediated reaction.<\/jats:p>","DOI":"10.1515\/znc-1998-3-414","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T11:36:42Z","timestamp":1533209802000},"page":"241-249","source":"Crossref","is-referenced-by-count":16,"title":["Superoxide-Dependent and -Independent Nitrite Formation from Hydroxylamine: Inhibition by Plant Extracts"],"prefix":"10.1515","volume":"53","author":[{"given":"Ute","family":"Rohnert","sequence":"first","affiliation":[{"name":"Lehrstuhl f\u00fcr Phytopathologie, Labor f\u00fcr Angewandte Biochemie, Technische Universit\u00e4t M\u00fcnchen, 85350 Freising-Weihenstephan, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Schneider","sequence":"additional","affiliation":[{"name":"Fa. Steigerwald, Havelstra\u00dfe 5, 64295 Darmstadt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich F.","family":"Elstner","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Phytopathologie, Labor f\u00fcr Angewandte Biochemie, Technische Universit\u00e4t M\u00fcnchen, 85350 Freising-Weihenstephan, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,6,2]]},"container-title":["Zeitschrift f\u00fcr Naturforschung C"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/znc.1998.53.issue-3-4\/znc-1998-3-414\/znc-1998-3-414.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-1998-3-414\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-1998-3-414\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T14:02:31Z","timestamp":1624370551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-1998-3-414\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4,1]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2014,6,2]]},"published-print":{"date-parts":[[1998,4,1]]}},"alternative-id":["10.1515\/znc-1998-3-414"],"URL":"https:\/\/doi.org\/10.1515\/znc-1998-3-414","relation":{},"ISSN":["1865-7125","0939-5075"],"issn-type":[{"value":"1865-7125","type":"electronic"},{"value":"0939-5075","type":"print"}],"subject":[],"published":{"date-parts":[[1998,4,1]]}}}