{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T01:05:07Z","timestamp":1648775107312},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"3-4","license":[{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p> The water accessibilities to aspartyl residues at positions 7 and 23 in the amyloid \u03b2 1\u201328 peptide associated with Alzheim er's Disease have been calculated using different techniques. These accessibilities of water were compared to those of the succinimidyl residues (SUC) replacing the aspartyl ones (ASP). It has been possible to ascertain that these modifications (A SP \u2192 SUC) lead to a significant increase in the water accessibility to the backbone and a-carbon atom of the SUC7 and SUC23 residues. It is suggested that the spontaneous trans\u00ad formation of ASP \u2192 SUC might lead to an increase of the racemization rates due to the higher accessibility of water at these sites. It is also proposed that the behavior of the adjacent residues in the selectivity of the racemization is to control the water accessibility at the reactive residue.<\/jats:p>","DOI":"10.1515\/znc-1999-3-418","type":"journal-article","created":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T13:47:59Z","timestamp":1423144079000},"page":"264-270","source":"Crossref","is-referenced-by-count":1,"title":["Solvent Accessibility to Aspartyl and Succinimidyl Residues at Positions 7 and 23 in the Amyloid \u03b2 1 - 28 Peptide"],"prefix":"10.1515","volume":"54","author":[{"given":"Roberto D.","family":"Lins","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, 92037-0365, CA - USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thereza A.","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, MB-5, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, 92037-1000, CA-USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental. Universidade Federal de Pernambuco Cidade Universit\u00e1ria. 50740-540, Recife, PE - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo L.","family":"Longo","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental. Universidade Federal de Pernambuco Cidade Universit\u00e1ria. 50740-540, Recife, PE - Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,6,2]]},"container-title":["Zeitschrift f\u00fcr Naturforschung C"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/znc.1999.54.issue-3-4\/znc-1999-3-418\/znc-1999-3-418.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-1999-3-418\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-1999-3-418\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T14:04:15Z","timestamp":1624370655000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-1999-3-418\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4,1]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2014,6,2]]},"published-print":{"date-parts":[[1999,4,1]]}},"alternative-id":["10.1515\/znc-1999-3-418"],"URL":"https:\/\/doi.org\/10.1515\/znc-1999-3-418","relation":{},"ISSN":["1865-7125","0939-5075"],"issn-type":[{"value":"1865-7125","type":"electronic"},{"value":"0939-5075","type":"print"}],"subject":[],"published":{"date-parts":[[1999,4,1]]}}}