{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:15:45Z","timestamp":1773663345161,"version":"3.50.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1-2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p> The CCl<jats:sub>4<\/jats:sub>-induced development of liver damage was studied in monolayer cultures of pri\u00admary rat hepatocytes: (1) CCl<jats:sub>4<\/jats:sub> caused accumulation of triglycerides in hepatocytes following cytochrome P450 induction with \u03b2-naphthoflavone or metyrapone. Ethanol or a high dose of insulin plus triio\u00addothyronine had the same effect. (2) CCl<jats:sub>4<\/jats:sub> increased the synthesis of fatty acids and triglycer\u00ad ides and the rate of lipid esterification. Cholesterol and phospholipid synthesis from acetate was also increased. (3) CCl<jats:sub>4<\/jats:sub> reduced \u03b2-oxidation of fatty acids as assessed by CO<jats:sub>2<\/jats:sub>-release and ketone body formation. Hydrolysis of triglycerides was also reduced. (4) The content of unsaturated fatty acids in microsomal lipids was decreased by almost 50% after incubation with CCl<jats:sub>4<\/jats:sub>, while saturated fatty acids increased slightly. (5) CCl<jats:sub>4<\/jats:sub> exerted a pronounced inhibitory effect on the exocytosis of macromolecules (albumin), but did not affect secretion of bile acids from hepatocytes.<\/jats:p>","DOI":"10.1515\/znc-2001-1-218","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T12:56:38Z","timestamp":1423054598000},"page":"111-121","source":"Crossref","is-referenced-by-count":46,"title":["Pathogenesis of Carbon Tetrachloride-Induced Hepatocyte Injury Bioactivation of CCl<sub>4<\/sub> by Cytochrome P450 and Effects on Lipid Homeostasis"],"prefix":"10.1515","volume":"56","author":[{"given":"Meinrad","family":"Boll","sequence":"first","affiliation":[{"name":"Institute of Toxicology, GSF - National Research Center for Environment and Health, M\u00fcnchen, Ingolstaedter Landstrasse, D-85764 Neuherberg, Bundesrepublik Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz W. D.","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute of Toxicology, GSF - National Research Center for Environment and Health, M\u00fcnchen, Ingolstaedter Landstrasse, D-85764 Neuherberg, Bundesrepublik Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Becker","sequence":"additional","affiliation":[{"name":"Institute of Toxicology, GSF - National Research Center for Environment and Health, M\u00fcnchen, Ingolstaedter Landstrasse, D-85764 Neuherberg, Bundesrepublik Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Stampfl","sequence":"additional","affiliation":[{"name":"Institute of Toxicology, GSF - National Research Center for Environment and Health, M\u00fcnchen, Ingolstaedter Landstrasse, D-85764 Neuherberg, Bundesrepublik Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,6,2]]},"container-title":["Zeitschrift f\u00fcr Naturforschung C"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/znc.2001.56.issue-1-2\/znc-2001-1-218\/znc-2001-1-218.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2001-1-218\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2001-1-218\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T05:36:18Z","timestamp":1661232978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2001-1-218\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2,1]]},"references-count":0,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2014,6,2]]},"published-print":{"date-parts":[[2001,2,1]]}},"alternative-id":["10.1515\/znc-2001-1-218"],"URL":"https:\/\/doi.org\/10.1515\/znc-2001-1-218","relation":{},"ISSN":["1865-7125","0939-5075"],"issn-type":[{"value":"1865-7125","type":"electronic"},{"value":"0939-5075","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2,1]]}}}