{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T23:44:23Z","timestamp":1775346263333,"version":"3.50.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"3-4","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Changes of lipoprotein secretion and composition in response to CCl<jats:sub>4<\/jats:sub> treatment were studied in monolayer cultures of rat primary hepatocytes. <\/jats:p>\n               <jats:p>(1) CCl<jats:sub>4<\/jats:sub> decreased secretion of very low density lipoproteins (VLDL) by about 85%, while high density lipoprotein (HDL) secretion was less affected (about 40%). The effect was concentration-dependent. (2) CCl<jats:sub>4<\/jats:sub> significantly inhibited secretion of VLDL-and HDL-associated triglycerides and cholesterol esters. VLDL-and HDL-associated cholesterol was not affected, while secretion of phospholipids was increased. (3) Hepatocytes secreted the apolipoproteins B<jats:sub>48<\/jats:sub>, B <jats:sub>100<\/jats:sub>, E, C, and A-I. CCl<jats:sub>4<\/jats:sub> reduced secretion of apoproteins associated with VLDL by almost 20%, and by about 75% when associated with HDL. The de novo synthesis of apolipoproteins was attenuated by CCl<jats:sub>4<\/jats:sub>. (4) CCl<jats:sub>4<\/jats:sub> caused variations in the apolipoprotein composition in VLDL and HDL.<\/jats:p>\n               <jats:p> CCl<jats:sub>4<\/jats:sub> intoxication of the liver affected the morphology and\/or function of the lipoproteins, which drastically impaired their ability to act as transport vehicles for lipids from the liver to the circulation.<\/jats:p>","DOI":"10.1515\/znc-2001-3-419","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T12:56:38Z","timestamp":1423054598000},"page":"283-290","source":"Crossref","is-referenced-by-count":33,"title":["Hepatocyte Damage Induced by Carbon Tetrachloride: Inhibited Lipoprotein Secretion and Changed Lipoprotein Composition"],"prefix":"10.1515","volume":"56","author":[{"given":"Meinrad","family":"Boll","sequence":"first","affiliation":[{"name":"Institute of Toxicology, GSF - National Research Center for Environment and Health, M\u00fcnchen, Ingolst\u00e4dter Landstrasse, D-85764 Neuherberg, Bundesrepublik Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz W. D.","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute of Toxicology, GSF - National Research Center for Environment and Health, M\u00fcnchen, Ingolst\u00e4dter Landstrasse, D-85764 Neuherberg, Bundesrepublik Deutschland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard","family":"Becker","sequence":"additional","affiliation":[{"name":"Institute of Toxicology, GSF - National Research Center for Environment and Health, M\u00fcnchen, Ingolst\u00e4dter Landstrasse, D-85764 Neuherberg, Bundesrepublik Deutschland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Stampfl","sequence":"additional","affiliation":[{"name":"Institute of Toxicology, GSF - National Research Center for Environment and Health, M\u00fcnchen, Ingolst\u00e4dter Landstrasse, D-85764 Neuherberg, Bundesrepublik Deutschland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,6,2]]},"container-title":["Zeitschrift f\u00fcr Naturforschung C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/znc\/56\/3-4\/article-p283.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2001-3-419\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2001-3-419\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T05:40:31Z","timestamp":1661233231000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2001-3-419\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,1]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2014,6,2]]},"published-print":{"date-parts":[[2001,4,1]]}},"alternative-id":["10.1515\/znc-2001-3-419"],"URL":"https:\/\/doi.org\/10.1515\/znc-2001-3-419","relation":{},"ISSN":["1865-7125","0939-5075"],"issn-type":[{"value":"1865-7125","type":"electronic"},{"value":"0939-5075","type":"print"}],"subject":[],"published":{"date-parts":[[2001,4,1]]}}}