{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:14:58Z","timestamp":1759529698056},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1-2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,2,1]]},"abstract":"<jats:p>The effect of different \u029f-phenylalanine (Phe) concentrations (0.12D12.1 m\u1d0d) on acetylcholinesterase (AChE), (Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>)-ATPase and Mg<jats:sup>2+<\/jats:sup>-ATPase activities was evaluated in homogenates of suckling rat frontal cortex, hippocampus and hypothalamus. Phe, at high concentrations, reduced AChE activity in frontal cortex and hippocampus by 18%-20%. On the contrary, the enzyme activity was unaltered in the hypothalamus. Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>-ATPase was stimulated by high levels of the amino acid, both in the frontal cortex and the hypothalamus by 60%, whereas it was inhibited in the hippocampus by 40%. Mg<jats:sup>2+<\/jats:sup>-ATPase was not influenced by Phe. It is suggested that: a) In the frontal cortex, the improper acetylcholine (ACh) release, due to AChE inhibition by Phe, combined with the stimulation of Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>-ATPase, possibly explain tremor and the hyperkinetic behaviour in patients with classical phenylketonuria (PKU). b) In the hippocampus, inhibition of AChE by Phe could lead to problems in memory, while Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>-ATPase inhibition by Phe may induce metabolic disorders and electrical instability of the synaptosomal membrane. c) In the hypothalamus, the behavioral problems in PKU \u201coff diet\u201d may be related to noradrenaline (NA) levels, which are probably correlated with the modulated Na<jats:sup>+<\/jats:sup>,K<jats:sup>+<\/jats:sup>-ATPase by Phe.<\/jats:p>","DOI":"10.1515\/znc-2002-1-230","type":"journal-article","created":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T13:48:16Z","timestamp":1423144096000},"page":"182-188","source":"Crossref","is-referenced-by-count":15,"title":["Effects of \u029f-Phenylalanine on Acetylcholinesterase and Na<sup>+<\/sup>,K<sup>+<\/sup>-ATPase Activities in Suckling Rat Frontal Cortex, Hippocampus and Hypothalamus"],"prefix":"10.1515","volume":"57","author":[{"given":"Artemis","family":"Doulgeraki","sequence":"first","affiliation":[{"name":"Department of Experimental Physiology, Medical School, University of Athens, P. O. Box 65257, GR-154 01, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zetta","family":"Papadopoulou-Daifoti","sequence":"additional","affiliation":[{"name":"Department of Experimental Pharmacology, Medical School, University of Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stylianos","family":"Tsakiris","sequence":"additional","affiliation":[{"name":"Department of Experimental Physiology, Medical School, University of Athens, P. O. Box 65257, GR-154 01, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,6,2]]},"container-title":["Zeitschrift f\u00fcr Naturforschung C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/znc\/57\/1-2\/article-p182.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2002-1-230\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2002-1-230\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T05:23:12Z","timestamp":1661232192000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2002-1-230\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2,1]]},"references-count":0,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2014,6,2]]},"published-print":{"date-parts":[[2002,2,1]]}},"alternative-id":["10.1515\/znc-2002-1-230"],"URL":"https:\/\/doi.org\/10.1515\/znc-2002-1-230","relation":{},"ISSN":["1865-7125","0939-5075"],"issn-type":[{"value":"1865-7125","type":"electronic"},{"value":"0939-5075","type":"print"}],"subject":[],"published":{"date-parts":[[2002,2,1]]}}}