{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:57:45Z","timestamp":1780541865352,"version":"3.54.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"11-12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,12,1]]},"abstract":"<jats:p>Antitubercular bioassay-guided fractionation of the dichloromethane extracts of the above-ground biomass and roots of Quinchamalium majus led to the identification of six known constituents, betulinic acid (1), daucosterol (2), 5,7-dihydroxyflavone (3), oleanolic acid (4), (D)-2S-pinocembrin (5), and ursolic acid (6), for the first time in this species. Their chemical structures were determined on the basis of spectroscopic evidence and chemical transformation methods. All of these compounds along with additional 11 analogues were evaluated for their antitubercular potential against Mycobacterium tuberculosis in a microplate alamar blue assay, and the primary structure-activity relationships (SARs) for 4 and 6 were discussed. In addition, all the isolates were tested for cytotoxicity against African green monkey Vero cells in order to evaluate for their selectivity potential.<\/jats:p>","DOI":"10.1515\/znc-2004-11-1206","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T12:58:43Z","timestamp":1423054723000},"page":"797-802","source":"Crossref","is-referenced-by-count":13,"title":["Constituents of Quinchamalium majus with Potential Antitubercular Activity"],"prefix":"10.1515","volume":"59","author":[{"given":"Jian-Qiao","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Arizona, 1703 East Mabel St., Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehong","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Tuberculosis Research (M\/C 964), College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott G.","family":"Franzblau","sequence":"additional","affiliation":[{"name":"Institute for Tuberculosis Research (M\/C 964), College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Vegetales, Facultad de Agronom\u00eda e Ingenier\u00eda Forestal, Pontificia Universidad Cat\u00f3lica de Chile, Avenida Vicu\u00f1a Mackenna 4860, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara N.","family":"Timmermann","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Division of Medicinal and Natural Products Chemistry, College of Pharmacy, University of Arizona, 1703 East Mabel St., Tucson, AZ 85721, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,6,2]]},"container-title":["Zeitschrift f\u00fcr Naturforschung C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/znc\/59\/11-12\/article-p797.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2004-11-1206\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2004-11-1206\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T05:08:47Z","timestamp":1661231327000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2004-11-1206\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,1]]},"references-count":0,"journal-issue":{"issue":"11-12","published-online":{"date-parts":[[2014,6,2]]},"published-print":{"date-parts":[[2004,12,1]]}},"alternative-id":["10.1515\/znc-2004-11-1206"],"URL":"https:\/\/doi.org\/10.1515\/znc-2004-11-1206","relation":{},"ISSN":["1865-7125","0939-5075"],"issn-type":[{"value":"1865-7125","type":"electronic"},{"value":"0939-5075","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12,1]]}}}