{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:40:21Z","timestamp":1790728821911,"version":"4.1.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"5-6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:p>The aim of the present study was to evaluate for the first time the in vitro cytotoxic activity of fractions and isolated flavonols from Salsola oppositifolia Desf. (Amaranthaceae). The nhexane fraction demonstrated an effective cytotoxic activity on the large lung carcinoma and amelanotic melanoma cell lines with IC<jats:sub>50<\/jats:sub> values of 19.1 \u03bcg\/ml and 24.4 \u03bcg\/ml, respectively. Also the dichloromethane fraction exhibited cytotoxic activity against COR-L23 (IC<jats:sub>50<\/jats:sub> 30.4 \u03bcg\/ml) and C32 (IC<jats:sub>50<\/jats:sub> 33.2 \u03bcg\/ml) cells, while the EtOAc fraction demonstrated a selective cytotoxic activity against MCF-7 cells (IC<jats:sub>50<\/jats:sub> 67.9 \u03bcg\/ml). The major active constituents of this fraction were isorhamnetin-3-O-glucoside (1) and isorhamnetin-3-O-rutinoside (2), which showed an interesting activity against the cell line MCF-7 with IC<jats:sub>50<\/jats:sub> values of 18.2 and 25.2 \u03bcg\/ml, respectively. Compound 2 exhibited a strong activity against the hormonedependent prostate carcinoma LNCaP cell line with an IC<jats:sub>50<\/jats:sub> of 20.5 \u03bcg\/ml. Constituents of S. oppositifolia were identified by GC-MS and NMR analyses.<\/jats:p>","DOI":"10.1515\/znc-2008-5-607","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T13:07:24Z","timestamp":1423055244000},"page":"347-354","source":"Crossref","is-referenced-by-count":23,"title":["In vitro Cytotoxic Activity of Salsola oppositifolia Desf. (Amaranthaceae) in a Panel of Tumour Cell Lines"],"prefix":"10.1515","volume":"63","author":[{"given":"Rosa","family":"Tundis","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, I-87030 Rende (CS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica R.","family":"Loizzo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, I-87030 Rende (CS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bonesi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, I-87030 Rende (CS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Menichini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, I-87030 Rende (CS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo A.","family":"Statti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, I-87030 Rende (CS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Menichini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, I-87030 Rende (CS), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,6,2]]},"container-title":["Zeitschrift f\u00fcr Naturforschung C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/znc\/63\/5-6\/article-p347.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2008-5-607\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2008-5-607\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T06:17:01Z","timestamp":1624342621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2008-5-607\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,1]]},"references-count":0,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2014,6,2]]},"published-print":{"date-parts":[[2008,6,1]]}},"alternative-id":["10.1515\/znc-2008-5-607"],"URL":"https:\/\/doi.org\/10.1515\/znc-2008-5-607","relation":{},"ISSN":["1865-7125","0939-5075"],"issn-type":[{"value":"1865-7125","type":"electronic"},{"value":"0939-5075","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6,1]]}}}