{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T11:11:12Z","timestamp":1781349072014,"version":"3.54.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"7-8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"<jats:p>Triterpenoids with 31-norcycloartanone structure were isolated for the first time from the Solanum genus. Cycloeucalenone and 24-oxo-31-norcycloartanone were the main constituents of the dichloromethane extract of Solanum cernuum Vell. leaves [7% (w\/w) and 1.47% (w\/w)]. Both triterpenoids were tested against human tumour cell lines, and 24-oxo-31-norcycloartanone was significantly active and selective against the lung tumour cell line NCI-H460 with total growth inhibition at 1.10 \u03bcg\/mL, growth inhibition 50 at 0.19 \u03bcg\/mL and lethal concentration 50 at 8.43 \u03bcg\/mL, while cycloeucalenone showed poor activity. A homologous series of alkanes (C<jats:sub>25<\/jats:sub>-C<jats:sub>34<\/jats:sub>), \u03b2-sitosterol, and the xanthophyll lutein were also identified. The antiulcer activity was assayed for the dichloromethane extract. In the gastric ulcer model induced by 95% ethanol, administration of 500, 1000 and 2000 mg\/kg\/po dichloromethane extract gave ulcer lesion indices of, respectively, 38.2, 61.0 and 81.9%, while carbenoxolone inhibited 88.9% at 200 mg\/kg. In the gastric ulcer model induced by indomethacin the dichloromethane extract showed a small percentage of lesion inhibition. The ethanol extract was also analyzed and was mainly composed of glycoalkaloids, peptides and disaccharides. <\/jats:p>","DOI":"10.1515\/znc-2008-7-807","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T13:07:24Z","timestamp":1423055244000},"page":"507-514","source":"Crossref","is-referenced-by-count":13,"title":["Antineoplastic 31-Norcycloartanones from Solanum cernuum Vell"],"prefix":"10.1515","volume":"63","author":[{"given":"Rog\u00e9rio","family":"Grando","sequence":"first","affiliation":[{"name":"Faculdade de Farm\u00e1cia da Universidade Metodista de Piracicaba, Rodovia do A\u00e7\u00facar Km 156, 13400-911 Taquaral, Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia A.","family":"Ant\u00f4nio","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Francisco, Av S\u00e3o Francisco Assis 218, Caixa Postal 163, 12916900 Braganca Paulista, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos E. P.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Francisco, Av S\u00e3o Francisco Assis 218, Caixa Postal 163, 12916900 Braganca Paulista, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Soares","sequence":"additional","affiliation":[{"name":"REQUIMTE\/CQFB, Departamento de Qu\u00edmica, FCT, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Engenharia, Tecnologia e Inova\u00e7\u00e3o, Departamento de Tecnologia das Ind\u00fastrias Qu\u0131\u00edmicas, Azinhaga dos Lameiros, 1699-038 Lisboa, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o E. de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"CPQBA D Centro Pluridisciplinar de Pesquisas Qu\u00edmicas, Biol\u00f3gicas e Agron\u00f4micas da Universidade de Campinas, UNICAMP, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"REQUIMTE\/CQFB, Departamento de Qu\u00edmica, FCT, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciane C.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia da Universidade Metodista de Piracicaba, Rodovia do A\u00e7\u00facar Km 156, 13400-911 Taquaral, Piracicaba, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,6,2]]},"container-title":["Zeitschrift f\u00fcr Naturforschung C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/znc\/63\/7-8\/article-p507.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2008-7-807\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2008-7-807\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T06:17:10Z","timestamp":1624342630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2008-7-807\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,1]]},"references-count":0,"journal-issue":{"issue":"7-8","published-online":{"date-parts":[[2014,6,2]]},"published-print":{"date-parts":[[2008,8,1]]}},"alternative-id":["10.1515\/znc-2008-7-807"],"URL":"https:\/\/doi.org\/10.1515\/znc-2008-7-807","relation":{},"ISSN":["1865-7125","0939-5075"],"issn-type":[{"value":"1865-7125","type":"electronic"},{"value":"0939-5075","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8,1]]}}}