{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:05:57Z","timestamp":1775235957123,"version":"3.50.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"9-10","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,1]]},"abstract":"<jats:p>A number of 1,3,4-oxadiazole, 3 - 9, and 1,2,4-triazole derivatives, 13 - 15, were synthesized starting form the acid hydrazide 1. The 1,3,4-thiadiazole derivative 12 was prepared from the substituted phenylthiosemicarbazide derivative 11 by treatment with sulfuric acid. The aryl hydrazone derivatives 10a - c were synthesized by reaction of the hydrazide 1 with the corresponding ketones. The thioalkyl derivatives 16a - e were prepared by akylation of the thiol derivatives 3 and 13 with different alkylating agents. The newly synthesized compounds were tested for their anti-HBV activity and some of these compounds showed high antiviral activity<\/jats:p>","DOI":"10.1515\/znc-2008-9-1010","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T13:07:24Z","timestamp":1423055244000},"page":"667-674","source":"Crossref","is-referenced-by-count":15,"title":["Anti-Hepatitis B Virus Activity of New 1,2,4-Triazol-2-yl- and 1,3,4-Oxadiazol-2-yl-2-pyridinone Derivatives"],"prefix":"10.1515","volume":"63","author":[{"given":"Farag A.","family":"El-Essawy","sequence":"first","affiliation":[{"name":"Faculty of Science, Department of Chemistry, Menoufia University, Shebin El-Koam, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael A.","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Photochemistry Department, National Research Center, El Dokki, Cairo, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif A.","family":"El-Kafrawy","sequence":"additional","affiliation":[{"name":"National Liver Institute, Menoufia University, Shebin El-Koam, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa S.","family":"Morshedy","sequence":"additional","affiliation":[{"name":"Faculty of Science, Department of Chemistry, Menoufia University, Shebin El-Koam, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel-H.","family":"Abdel-Rahman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Menoufia University, Shebin El-Koam, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,6,2]]},"container-title":["Zeitschrift f\u00fcr Naturforschung C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/znc\/63\/9-10\/article-p667.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2008-9-1010\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2008-9-1010\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T06:17:12Z","timestamp":1624342632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2008-9-1010\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,1]]},"references-count":0,"journal-issue":{"issue":"9-10","published-online":{"date-parts":[[2014,6,2]]},"published-print":{"date-parts":[[2008,10,1]]}},"alternative-id":["10.1515\/znc-2008-9-1010"],"URL":"https:\/\/doi.org\/10.1515\/znc-2008-9-1010","relation":{},"ISSN":["1865-7125","0939-5075"],"issn-type":[{"value":"1865-7125","type":"electronic"},{"value":"0939-5075","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10,1]]}}}