{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:38:24Z","timestamp":1792103904281,"version":"4.4.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1-2","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:p>Terpinen-4-ol is a monoterpenoid alcohol and component of the essential oils of several aromatic plants. Similarly to terpinen-4-ol, other monoterpenoid alcohols have shown anticonvulsant activity in convulsion animal models. The present study aimed to investigate the anticonvulsant activity of terpinen-4-ol. Treatment of mice with terpinen-4-ol ( 200 mg\/kg) caused a signifi cant decrease in the spontaneous motor activity at 30, 60 and 120 min after administration. Terpinen-4-ol (100 and 200 mg\/kg) produced a significant dosedependent increase in the duration of sleeping in mice. Pretreatment of mice with terpinen-4- ol at doses of 100, 200 and 300 mg\/kg significantly increased the latency of pentylenetetrazole -induced convulsions. Terpinen-4-ol (200 and 300 mg\/kg) also inhibited the induced seizures of picrotoxin. In another model, maximal electroshock seizure, terpinen-4-ol decreased the tonic hind convulsions percentage at the dose of 300 mg\/kg. From the overall results we can conclude that terpinen-4-ol showed a depressant effect on the central nervous system and significant anticonvulsant activity.<\/jats:p>","DOI":"10.1515\/znc-2009-1-201","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T12:36:02Z","timestamp":1422621362000},"page":"1-5","source":"Crossref","is-referenced-by-count":29,"title":["Evaluation of the Anticonvulsant Activity of Terpinen-4-ol"],"prefix":"10.1515","volume":"64","author":[{"given":"Dami\u00e3o P. de","family":"Sousa","sequence":"first","affiliation":[{"name":"Departamento de Fisiologia, Universidade Federal de Sergipe, CEP 49100 \u2013 000, S\u00e3o Crist\u00f3v\u00e3o, Sergipe, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin F. F.","family":"N\u00f3brega","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Tecnologia Farmac\u00eautica, Universidade Federal da Para\u00edba, Caixa Postal 5009, CEP 58051 \u2013 970, Jo\u00e3o Pessoa, Para\u00edba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana C. S. L. de","family":"Morais","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Tecnologia Farmac\u00eautica, Universidade Federal da Para\u00edba, Caixa Postal 5009, CEP 58051 \u2013 970, Jo\u00e3o Pessoa, Para\u00edba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinaldo N. de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Tecnologia Farmac\u00eautica, Universidade Federal da Para\u00edba, Caixa Postal 5009, CEP 58051 \u2013 970, Jo\u00e3o Pessoa, Para\u00edba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2014,6,2]]},"container-title":["Zeitschrift f\u00fcr Naturforschung C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/znc\/64\/1-2\/article-p1.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2009-1-201\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2009-1-201\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T06:17:11Z","timestamp":1624342631000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2009-1-201\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,1]]},"references-count":0,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2014,6,2]]},"published-print":{"date-parts":[[2009,6,1]]}},"alternative-id":["10.1515\/znc-2009-1-201"],"URL":"https:\/\/doi.org\/10.1515\/znc-2009-1-201","relation":{},"ISSN":["1865-7125","0939-5075"],"issn-type":[{"value":"1865-7125","type":"electronic"},{"value":"0939-5075","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6,1]]}}}