{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:24:23Z","timestamp":1648513463732},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"3-4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:p>Mice responses to immunization with Schistosoma mansoni antigens were investigated. Priming with cercarial antigen preparation (CAP) induced significant (P &lt; 0.05) IgM, IgG, IgG2a, IgG2b, and IgA increases, while booster caused a significant IgG1 increase. A soluble worm antigen preparation (SWAP) caused significant IgG elevation. Priming with soluble egg antigen (SEA) caused significant IgM and IgG2a increases, while booster induced significant IgM, IgG and IgA increases. CAP-immunized mice sera (IMS) recognized CAP peptides ranging from 23 - 78 kDa. SWAP-IMS recognized SWAP peptides ranging from 40 - 75 kDa. SEA-IMS recognized SEA peptides ranging from 33 - 101 kDa. The cross-reactive peptides among the 3 antigens were identified. CAP caused significant increases in mesenteric lymph nodes (MLNs) CD<jats:sub>4,8<\/jats:sub>\n                  <jats:sup>+<\/jats:sup>, B lymphocytes, CD<jats:sub>8<\/jats:sub>\n                  <jats:sup>+<\/jats:sup> thymocytes, CD<jats:sub>4<\/jats:sub>\n                  <jats:sup>+<\/jats:sup> T and B splenocytes. SWAP priming caused significant increases in MLNs CD<jats:sub>4,8<\/jats:sub>\n                  <jats:sup>+<\/jats:sup> thymocytes and B splenocytes. SWAP booster caused significant increases in MLNs CD<jats:sub>8<\/jats:sub>\n                  <jats:sup>+<\/jats:sup> T and B lymphocytes, CD<jats:sub>4,8<\/jats:sub>\n                  <jats:sup>+<\/jats:sup> thymocytes and CD<jats:sub>4<\/jats:sub>\n                  <jats:sup>+<\/jats:sup> T and B splenocytes. SEA caused significant increase in CD<jats:sub>4<\/jats:sub>\n                  <jats:sup>+<\/jats:sup> T cells.<\/jats:p>","DOI":"10.1515\/znc-2010-3-419","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T12:36:36Z","timestamp":1422621396000},"page":"289-302","source":"Crossref","is-referenced-by-count":4,"title":["Immune Responses in Mice after Immunization with Antigens from Different Stages of the Parasite Schistosoma mansoni"],"prefix":"10.1515","volume":"65","author":[{"given":"Hanaa M.","family":"Gaber","sequence":"first","affiliation":[{"name":"Therapeutical Chemistry Department, Immunology and Infectious Diseases Laboratory, the Center of Excellence for Advanced Sciences, the National Research Center, Dokki, Cairo 12311, Egypt. Fax: 0 02 02-33 37-09 31"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany S.","family":"Maghraby","sequence":"additional","affiliation":[{"name":"Therapeutical Chemistry Department, Immunology and Infectious Diseases Laboratory, the Center of Excellence for Advanced Sciences, the National Research Center, Dokki, Cairo 12311, Egypt. Fax: 0 02 02-33 37-09 31"},{"name":"Therapeutic Chemistry Department, the National Research Center, Dokki, Cairo 12311, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Bastawy","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Faculty of Science, Beni Suef University, Beni Suef, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Ruppel","sequence":"additional","affiliation":[{"name":"Department of Tropical Hygiene and Public Health, Institute of Hygiene, University of Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud M.","family":"Bahgat","sequence":"additional","affiliation":[{"name":"Therapeutical Chemistry Department, Immunology and Infectious Diseases Laboratory, the Center of Excellence for Advanced Sciences, the National Research Center, Dokki, Cairo 12311, Egypt. Fax: 0 02 02-33 37-09 31"},{"name":"Therapeutic Chemistry Department, the National Research Center, Dokki, Cairo 12311, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2014,6,2]]},"container-title":["Zeitschrift f\u00fcr Naturforschung C"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/znc\/65\/3-4\/article-p289.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2010-3-419\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2010-3-419\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T14:14:59Z","timestamp":1624371299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/znc-2010-3-419\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,1]]},"references-count":0,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2014,6,2]]},"published-print":{"date-parts":[[2010,4,1]]}},"alternative-id":["10.1515\/znc-2010-3-419"],"URL":"https:\/\/doi.org\/10.1515\/znc-2010-3-419","relation":{},"ISSN":["1865-7125","0939-5075"],"issn-type":[{"value":"1865-7125","type":"electronic"},{"value":"0939-5075","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4,1]]}}}