{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:27:46Z","timestamp":1762324066404},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"7-8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,14]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n               <jats:p>\n                  <jats:italic>Tricholoma populinum<\/jats:italic> Lange is an edible basidiomycete from the family Tricholomataceae. Extracts, fractions, and different metabolites isolated from the fruiting bodies of this mushroom were tested for degranulation-inhibiting activities on RBL-2H3 cells (rat basophils). Dichloromethane extracts decreased degranulation significantly, as did a fraction after column chromatography. In addition, the extract decreased the IL-2 release from Jurkat T cells and the release of IL-8 from HMC-1 human mast cells. The results show the significant effects of extracts of <jats:italic>T. populinum<\/jats:italic> on cells of the innate (basophils and mast cells) and adaptive (T cells) immune system and indicate the influence of the mushroom on different immunological processes. As one fraction showed activity, it seems to be possible that it includes an active principle. The compounds responsible for this effect, however, could not be identified as the contents oleic acid (<jats:bold>1<\/jats:bold>), ergosterol peroxide (<jats:bold>2<\/jats:bold>), and 9,11-dehydroergosterol peroxide (<jats:bold>3<\/jats:bold>) showed no effects. Nevertheless, the mushroom could be used for supporting allergy treatment in future studies.<\/jats:p>","DOI":"10.1515\/znc-2016-0247","type":"journal-article","created":{"date-parts":[[2017,3,19]],"date-time":"2017-03-19T10:01:28Z","timestamp":1489917688000},"page":"277-283","source":"Crossref","is-referenced-by-count":4,"title":["Effects of extracts and compounds from <i>Tricholoma populinum<\/i> Lange on degranulation and IL-2\/IL-8 secretion of immune cells"],"prefix":"10.1515","volume":"72","author":[{"given":"Simon","family":"Merdivan","sequence":"first","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical Biology, Ernst-Moritz-Arndt University Greifswald , Felix-Hausdorff-Str. 1 , 17487 Greifswald , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Jenett-Siems","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy , Freie Universit\u00e4t Berlin , Berlin , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Siems","sequence":"additional","affiliation":[{"name":"AnalytiCon Discovery GmbH , Potsdam , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo H.J.","family":"Niedermeyer","sequence":"additional","affiliation":[{"name":"Interfaculty Institute of Microbiology and Infection Medicine , Eberhard Karls University , T\u00fcbingen , Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site , T\u00fcbingen , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadin","family":"Schultze","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy , Ernst-Moritz-Arndt University Greifswald , Greifswald , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Steinborn","sequence":"additional","affiliation":[{"name":"Center for Complementary Medicine, Institute for Environmental Health Sciences and Hospital Infection Control, Faculty of Medicine , University of Freiburg , Freiburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Gr\u00fcndemann","sequence":"additional","affiliation":[{"name":"Center for Complementary Medicine, Institute for Environmental Health Sciences and Hospital Infection Control, Faculty of Medicine , University of Freiburg , Freiburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Lindequist","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy , Ernst-Moritz-Arndt University Greifswald , Greifswald , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"2021062203202451550_j_znc-2016-0247_ref_001_w2aab3b7c54b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Grubisha LC, Levsen N, Olson MS, Taylor DL. 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