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Aimed to evaluate the efficacy of <jats:italic>L. meyenii<\/jats:italic> in persistent pain, the present study analyzed the effects of a commercial root extract from maca in different animal models reproducing the most common causes of chronic painful pathologies. A qualitative characterization of this commercial extract by high performance liquid chromatography-mass spectrometry and tandem mass spectrometry analyses allowed us to confirm the presence of some macamides known as bioactive constituents of this root and the absence of the main aromatic glucosinolates. The acute oral administration of maca extract is able to reduce mechanical hypersensitivity and postural unbalance induced by the intra-articular injection of monoiodoacetate and the chronic-constriction injury of the sciatic nerve. Furthermore, <jats:italic>L. meyenii<\/jats:italic> extract reverts pain threshold alterations evoked by oxaliplatin and paclitaxel. A good safety profile in mice and rats was shown. In conclusion, the present maca extract could be considered as a therapeutic opportunity to relieve articular and neuropathic pain.<\/jats:p>","DOI":"10.1515\/znc-2016-0251","type":"journal-article","created":{"date-parts":[[2017,8,20]],"date-time":"2017-08-20T10:03:00Z","timestamp":1503223380000},"page":"449-457","source":"Crossref","is-referenced-by-count":17,"title":["Effects of a water extract of <i>Lepidium meyenii<\/i> root in different models of persistent pain in rats"],"prefix":"10.1515","volume":"72","author":[{"given":"Barbara","family":"Tenci","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health \u2013 NEUROFARBA \u2013 Pharmacology and Toxicology Section , University of Florence , Florence , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8374-4432","authenticated-orcid":false,"given":"Lorenzo","family":"Di Cesare Mannelli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health \u2013 NEUROFARBA \u2013 Pharmacology and Toxicology Section , University of Florence , Viale Pieraccini 6 , 50139 Florence , Italy , Tel.: +39-055-2758395"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Maresca","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health \u2013 NEUROFARBA \u2013 Pharmacology and Toxicology Section , University of Florence , Florence , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Micheli","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Psychology, Drug Research and Child Health \u2013 NEUROFARBA \u2013 Pharmacology and Toxicology Section , University of Florence , Florence , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Pieraccini","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Center (CISM) of University of Florence , Viale G. 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