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The well detectable fluorescence of ZnPcs allowed the cellular imaging, which suggested relatively high uptakes of ZnPcs into bacterial species. Complete photoinactivation was achieved with all studied ZnPc<jats:bold>1\u20134<\/jats:bold> for <jats:italic>Enterococcus faecalis<\/jats:italic> (<jats:italic>E. faecalis<\/jats:italic>) at a light dose of 15 J\/cm<jats:sup>2<\/jats:sup>. The photodynamic response was high for <jats:italic>Prevotella intermedia<\/jats:italic> (<jats:italic>P. intermedia<\/jats:italic>) after the application of 6 \u03bcM of ZnPc<jats:bold>1<\/jats:bold> and a light dose of 36 J\/cm<jats:sup>2<\/jats:sup> and for 6 \u03bcM of ZnPc<jats:bold>2<\/jats:bold> at 60 J\/cm<jats:sup>2<\/jats:sup>. <jats:italic>P. intermedia<\/jats:italic> was inactivated with ZnPc<jats:bold>3<\/jats:bold> (4 log) and ZnPc<jats:bold>4<\/jats:bold> (2 log) with irradiation at an optimal dose of 60 J\/cm<jats:sup>2<\/jats:sup>. Similar photoinactivation results (2 log) were achieved for <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> (<jats:italic>A. actinomycetemcomitans<\/jats:italic>) treated with 6 \u03bcM ZnPc<jats:bold>1<\/jats:bold> and ZnPc<jats:bold>2<\/jats:bold> at a light dose of 60 J\/cm<jats:sup>2<\/jats:sup>. The study suggested that PDI with quaternized Zn(II) phthalocyanines and specific light irradiation appears to be a very useful antimicrobial strategy for effective inactivation of drug-resistant periodontal pathogens.<\/jats:p>","DOI":"10.1515\/znc-2017-0167","type":"journal-article","created":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T22:17:09Z","timestamp":1515363429000},"page":"221-228","source":"Crossref","is-referenced-by-count":9,"title":["Quaternized Zn(II) phthalocyanines for photodynamic strategy against resistant periodontal bacteria"],"prefix":"10.1515","volume":"73","author":[{"given":"Vesselin","family":"Kussovski","sequence":"first","affiliation":[{"name":"The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. 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