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Besides, oxidative stress and genotoxicity were monitored by estimating the changes of total oxidative stress (TOS) and 8-hydroxy-2\u2032-deoxyguanosine (8-OH-dG) levels, respectively, in HLs. At the same time, OA- and PA-induced total antioxidant capacity (TAC) levels in HLs were determined. Although especially low concentrations of OA (IC<jats:sub>50<\/jats:sub>=109.94 mg\/L) and PA (IC<jats:sub>50<\/jats:sub>=665.49 mg\/L) did not show cytotoxic effect at high levels in HLs, it was revealed that cytotoxicity was significantly (p&lt;0.05) associated with oxidative stress and genotoxicity via correlation analysis. While TOS level in HLs did not statistically (p&gt;0.05) increase in the presence of all treatments (0.5\u2013100 mg\/L) of PA, TAC level was increased by PA applications in certain concentrations (0.5\u201310 mg\/L). Overall, the obtained data indicate that OA and especially PA as lichen compounds that do not cause oxidative stress can be a new resource of therapeutics as recognized in the present study with their high antioxidant features.<\/jats:p>","DOI":"10.1515\/znc-2017-0209","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T23:38:49Z","timestamp":1521934729000},"page":"303-312","source":"Crossref","is-referenced-by-count":20,"title":["Effects of two lichen acids isolated from <i>Pseudevernia furfuracea<\/i> (L.) Zopf in cultured human lymphocytes"],"prefix":"10.1515","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9636-2596","authenticated-orcid":false,"given":"Bugrahan","family":"Emsen","sequence":"first","affiliation":[{"name":"Department of Biology, Kamil \u00d6zda\u011f Faculty of Science , Karamano\u011flu Mehmetbey University , Karaman , Turkey , Phone: +90-3382263825, Fax: +90-3382262150"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basak","family":"Togar","sequence":"additional","affiliation":[{"name":"Department of Medical Services and Techniques , Vocational School of Health Services, Bayburt University , Bayburt , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Turkez","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics , Faculty of Science, Erzurum Technical University , Erzurum , Turkey"},{"name":"Department of Pharmacy , University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara , Chieti , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Aslan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy , Van Y\u00fcz\u00fcnc\u00fc Y\u0131l University , Van , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,3,24]]},"reference":[{"key":"2021062203212912600_j_znc-2017-0209_ref_001_w2aab3b7b7b1b6b1ab1b4b1Aa","doi-asserted-by":"crossref","unstructured":"Gago-Dominguez M, Castelao JE. 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