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Their structures were determined by their extensive spectroscopic data and comparison with the values reported in the references. All isolated compounds (<jats:bold>1<\/jats:bold>-<jats:bold>9<\/jats:bold>) were evaluated for their hepatoprotective activities on human L-O2 cells, which compared with positive control of Bifendatatum. Among them, compounds <jats:bold>1<\/jats:bold>, <jats:bold>2<\/jats:bold>, and <jats:bold>7<\/jats:bold> exhibited moderate hepatoprotective activities to promote effects on the proliferation of L-O2 cells.<\/jats:p>","DOI":"10.1515\/znc-2019-0202","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T12:39:47Z","timestamp":1594384787000},"page":"327-332","source":"Crossref","is-referenced-by-count":7,"title":["Bioactivity-guided isolation of aurone derivatives with hepatoprotective activities from the fruits of <i>Cucumis bisexualis<\/i>"],"prefix":"10.1515","volume":"75","author":[{"given":"Qin-Ge","family":"Ma","sequence":"first","affiliation":[{"name":"Key Laboratory of Modern Preparation of TCM of Ministry of Education , Jiangxi University of Traditional Chinese Medicine , Nanchang , 330004 , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3190-4478","authenticated-orcid":false,"given":"Rong-Rui","family":"Wei","sequence":"additional","affiliation":[{"name":"Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine , Jiangxi University of Traditional Chinese Medicine , Nanchang , 330004 , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Pei","family":"Sang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Pharmaceutical Engineering , Nanyang Normal University , Nanyang , 473061 , PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2020,6,23]]},"reference":[{"key":"2023040103053341715_j_znc-2019-0202_ref_001_w2aab3b7b9b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Li, CQ, Wang, ZY. Effect on antioxidation in type 2 diabetic mice extract of Cucumis bisexualis. China Health Care Nutr 2017;5:44\u20135. https:\/\/doi.org\/10.1021\/acs.jafc.8b00976.","DOI":"10.1021\/acs.jafc.8b00976"},{"key":"2023040103053341715_j_znc-2019-0202_ref_002_w2aab3b7b9b1b6b1ab2b2b2Aa","doi-asserted-by":"crossref","unstructured":"Ma, QG, Wei, RR, Yang, M, Huang, XY, Wang, F, Sang, ZP, et al. Molecular characterization and bioactivity of coumarin derivatives from the fruits of Cucumis bisexualis. J Agr Food Chem 2018;66:5540\u20138. https:\/\/doi.org\/10.1021\/acs.jafc.8b00976.","DOI":"10.1021\/acs.jafc.8b00976"},{"key":"2023040103053341715_j_znc-2019-0202_ref_003_w2aab3b7b9b1b6b1ab2b2b3Aa","doi-asserted-by":"crossref","unstructured":"Ma, QG, Wei, RR, Sang, ZP. Structural Characterization and hepatoprotective activity of naphthoquinone from Cucumis bisexualis. 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