{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:45:29Z","timestamp":1792057529776,"version":"4.4.0"},"reference-count":26,"publisher":"Walter de Gruyter GmbH","issue":"3-4","license":[{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>\n                  <jats:italic>Achillea moschata<\/jats:italic> Wulfen, which grows in the Alps, is extensively used by local people for its medicinal properties. Two studied samples were collected, at the flowering stage, in Val Mustair (Switzerland) and Valchiavenna (Italy), respectively. The aerial parts were defatted with petroleum ether (PET) and successively extracted with dichloromethane (DCM) and methanol (MeOH). High-performance liquid chromatography and electrospray ionization-tandem mass spectrometry analyses of the methanolic extracts evidenced that flavonoids were the predominant compounds compared to phenolic acids in both samples (89.5 vs. 33.0 \u03bcg\/mg DW in <jats:italic>A. moschata<\/jats:italic> Valchiavenna and 82.5 vs. 40.0 \u03bcg\/mg DW in <jats:italic>A. moschata<\/jats:italic> Val Mustair). Among flavonoid derivatives, luteolin and apigenin were the predominant aglycones, free and glycosilated. The <jats:italic>A. moschata<\/jats:italic> Valchiavenna extract was characterized by apigenin as the main compound (60.4 \u03bcg\/mg DW), while <jats:italic>A. moschata<\/jats:italic> Val Mustair was characterized by its derivative apigenin 7-<jats:italic>O<\/jats:italic>-glucoside (44.7 \u03bcg\/mg DW). The antioxidant activity of all the obtained extracts was tested by the DPPH (2,2-diphenyl-picryl hydrazyl) and ABTS (2,21-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) methods, which showed their increasing scavenger capacity in relation to extract polarity (PET extract\u2009&lt;\u2009DCM extract\u2009&lt;\u2009MeOH extract). The extracts were also investigated against three Gram-positive (<jats:italic>Bacillus cereus<\/jats:italic>, <jats:italic>Enterococcus faecalis<\/jats:italic> and <jats:italic>Staphylococcus aureus<\/jats:italic>) and three Gram-negative (<jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Proteus mirabilis<\/jats:italic> and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>) bacterial species using the disc diffusion assay. DMC and PET were the most active extracts (inhibition diameter: \u226512 mm).<\/jats:p>","DOI":"10.1515\/znc-2019-0214","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T09:24:46Z","timestamp":1582104286000},"page":"57-64","source":"Crossref","is-referenced-by-count":20,"title":["Polyphenol content and bioactivity of <i>Achillea moschata<\/i> from the Italian and Swiss Alps"],"prefix":"10.1515","volume":"75","author":[{"given":"Maria Pia","family":"Argentieri","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Sciences , University of Bari \u201cAldo Moro ,\u201d via Orabona 4 , 70125 Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira","family":"Madeo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology , Kiel University , Gutenbergstra\u00dfe 76 , 24118 Kiel , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinarosa","family":"Avato","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Sciences , University of Bari \u201cAldo Moro ,\u201d via Orabona 4 , 70125 Bari , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5063-1236","authenticated-orcid":false,"given":"Marcello","family":"Iriti","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Milano , Department of Agricultural and Environmental Sciences , Via G. Celoria 2 , 20133, Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Vitalini","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Milano , Department of Agricultural and Environmental Sciences , Via G. Celoria 2 , 20133, Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"2021082520010506265_j_znc-2019-0214_ref_001","doi-asserted-by":"crossref","unstructured":"Dauti A, Kapidani G, Pupuleku B, Kallajxhiu N, Jan\u00e7e A, Turku S. Palynomorphological data of some species of the genus Achillea. Acad J Interdiscip Stud 2016;5:S1.","DOI":"10.5901\/ajis.2016.v5n3s1p74"},{"key":"2021082520010506265_j_znc-2019-0214_ref_002","unstructured":"Pignatti S. Flora d\u2019Italia, 1st ed. Bologna: Edagricole, 1982."},{"key":"2021082520010506265_j_znc-2019-0214_ref_003","doi-asserted-by":"crossref","unstructured":"Grabherr G. Biodiversity in the high ranges of the Alps: ethnobotanical and climate change perspectives. Global Environ Change 2009;19:167\u201372.","DOI":"10.1016\/j.gloenvcha.2009.01.007"},{"key":"2021082520010506265_j_znc-2019-0214_ref_004","unstructured":"Tutin TG, Burges NA, Charter AO, Edmondson JR, Heywood VH, Moore DM, et al. Flora Europaea. Cambridge: Cambridge University Press, 1993."},{"key":"2021082520010506265_j_znc-2019-0214_ref_005","doi-asserted-by":"crossref","unstructured":"Abbet C, Mayor R, Roguet D, Spichige R, Hamburger M, Potterat O. Ethnobotanical survey on wild alpine food plants in Lower and Central Valais (Switzerland). J Ethnopharmacol 2014;151:624\u201334.","DOI":"10.1016\/j.jep.2013.11.022"},{"key":"2021082520010506265_j_znc-2019-0214_ref_006","doi-asserted-by":"crossref","unstructured":"Vitalini S, Iriti M, Puricelli C, Ciuchi D, Segale A, Fico G. Traditional knowledge on medicinal and food plants used in Val San Giacomo (Sondrio, Italy) \u2013 an alpine ethnobotanical study. J Ethnopharmacol 2013;145:517\u201329.","DOI":"10.1016\/j.jep.2012.11.024"},{"key":"2021082520010506265_j_znc-2019-0214_ref_007","doi-asserted-by":"crossref","unstructured":"Vitalini S, Puricelli C, Mikerezi I, Iriti M. Plants, people and traditions: ethnobotanical survey in the Lombard Stelvio National Park and neighbouring areas (Central Alps, Italy). J Ethnopharmacol 2015;173:435\u201358.","DOI":"10.1016\/j.jep.2015.05.036"},{"key":"2021082520010506265_j_znc-2019-0214_ref_008","doi-asserted-by":"crossref","unstructured":"Cory H, Passarelli S, Szeto J, Tamez M, Mattei J. The role of polyphenols in human health and food systems: a mini-review. Front Nutr 2018;5:87.","DOI":"10.3389\/fnut.2018.00087"},{"key":"2021082520010506265_j_znc-2019-0214_ref_009","doi-asserted-by":"crossref","unstructured":"Ganesan K, Xu B. A critical review on polyphenols and health benefits of black soybeans. Nutrients 2017;9:455.","DOI":"10.3390\/nu9050455"},{"key":"2021082520010506265_j_znc-2019-0214_ref_010","doi-asserted-by":"crossref","unstructured":"Pandey KB, Rizvi SI. Plant polyphenols as dietary antioxidants in human health and disease. Oxid Med Cell Longev 2009;2:270\u20138.","DOI":"10.4161\/oxim.2.5.9498"},{"key":"2021082520010506265_j_znc-2019-0214_ref_011","doi-asserted-by":"crossref","unstructured":"Salucci S, Falcieri E. Polyphenols and their potential role in preventing skeletal muscle atrophy. Nutr Res 2020;74:10\u201322.","DOI":"10.1016\/j.nutres.2019.11.004"},{"key":"2021082520010506265_j_znc-2019-0214_ref_012","doi-asserted-by":"crossref","unstructured":"Vitalini S, Madeo M, Tava A, Iriti M, Vallone L, Avato P, et al. Chemical profile, antioxidant and antibacterial activities of Achillea moschata Wulfen, an endemic species from the Alps. 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Influence of environmental factors on composition of phenolic antioxidants of Achillea collina Becker ex Rchb. Nat Prod Res 2010;24:1546\u201359.","DOI":"10.1080\/14786419.2010.490656"},{"key":"2021082520010506265_j_znc-2019-0214_ref_019","doi-asserted-by":"crossref","unstructured":"Vitalini S, Beretta G, Iriti M, Orsenigo S, Basilico N, Dall\u2019Acqua S, et al. Phenolic compounds from Achillea millefolium L. and their bioactivity. Acta Biochim Pol 2011;58:203\u20139.","DOI":"10.18388\/abp.2011_2266"},{"key":"2021082520010506265_j_znc-2019-0214_ref_020","doi-asserted-by":"crossref","unstructured":"Benedec D, Vlase L, Oniga I, Mot AC, Damian G, Hanganu D, et al. Polyphenolic composition, antioxidant and antibacterial activities for two Romanian subspecies of Achillea distans Waldst. Et Kit. Ex Willd. 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