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The oil was isolated from\n                    <jats:italic>T.\u00a0convolutus<\/jats:italic>\n                    using hydrodistillation method, analyzed by gas chromatography\/mass spectrometry (GC\u2013MS), and 66 compounds were identified. The main component was determined as\u00a0camphor at 16.6%. The antioxidant properties were identified with the DPPH (2,2\u2032-diphenyl-1-picrylhydrazyl) radical-scavenging method and, 33.39\u00a0\u00b1\u00a00.25% DPPH was scavenging in 1000\u00a0\u03bcg\/mL of essential oil. The strong antimicrobial activity was observed against\n                    <jats:italic>Escherichia coli, Enterobacter aerogenes, Proteus vulgaris,<\/jats:italic>\n                    and\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    with MIC values of 125\u00a0\u03bcg\/mL.\n                    <jats:italic>Aspergillus flavus<\/jats:italic>\n                    was more sensitive (28%) against\n                    <jats:italic>T.\u00a0convolutus<\/jats:italic>\n                    essential oil than other fungi. The cytotoxic effect of oil was analyzed by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. Camphor was effective on human hepatoma cells (Hep3B) at concentrations of 1\u00a0mg\/mL, 500, 250, and 125\u00a0\u03bcg\/mL, while essential oil of\n                    <jats:italic>T.\u00a0convolutus<\/jats:italic>\n                    was found to be effective at concentrations of 250 and 125\u00a0\u03bcg\/mL. A reduction in cell proliferation was observed in colon carcinoma cells (HT-29) treated with 500\u00a0\u03bcg\/mL camphor for 48\u00a0h. No statistically significant effect was found in Umbilical Vein Endothelial Cells (HUVEC) treated with essential oil and camphor.\n                  <\/jats:p>","DOI":"10.1515\/znc-2020-0070","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:51:48Z","timestamp":1611363108000},"page":"193-203","source":"Crossref","is-referenced-by-count":12,"title":["Essential oil chemical composition, antimicrobial, anticancer, and antioxidant effects of\n                    <i>Thymus convolutus<\/i>\n                    Klokov in Turkey"],"prefix":"10.1515","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0314-3301","authenticated-orcid":false,"given":"Selma","family":"Celen Yuceturk","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics , Faculty of Science and Literature, Balikesir University , 10145 Bal\u0131kesir , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1754-0700","authenticated-orcid":false,"given":"Sumeyye","family":"Aydogan Turkoglu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics , Faculty of Science and Literature, Balikesir University , 10145 Bal\u0131kesir , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2572-8391","authenticated-orcid":false,"given":"Feray","family":"Kockar","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics , Faculty of Science and Literature, Balikesir University , 10145 Bal\u0131kesir , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7784-4138","authenticated-orcid":false,"given":"F. Zehra","family":"Kucukbay","sequence":"additional","affiliation":[{"name":"Department of Basic Pharmaceutical Sciences, Division of Analytical Chemistry , Faculty of Pharmacy, \u0130n\u00f6n\u00fc University , 44280 Malatya , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7619-357X","authenticated-orcid":false,"given":"A. Dilek","family":"Azaz","sequence":"additional","affiliation":[{"name":"Department of Biology , Faculty of Science and Literature, Balikesir University , 10145 Bal\u0131kesir , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"2026041409463479149_j_znc-2020-0070_ref_001_w2aab3b7c13b1b6b1ab2b2b1Aa","unstructured":"Bruneton, J. Pharmacognosy, phytochemistry, medicinal plants, 2nd ed. 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Eur J Clin Microbiol Infect Dis 2013;32:1311\u201320. https:\/\/doi.org\/10.1007\/s10096-013-1881-1.","DOI":"10.1007\/s10096-013-1881-1"},{"key":"2026041409463479149_j_znc-2020-0070_ref_053_w2aab3b7c13b1b6b1ab2b2c53Aa","doi-asserted-by":"crossref","unstructured":"Lin, RJ, Lo, W, Wang, YD, Chen, CY. A novel cytotoxic monoterpenoid from the leaves of Cinnamomum subavenium. Nat Prod Res 2008;22:1055\u20139. https:\/\/doi.org\/10.1080\/14786410802228637.","DOI":"10.1080\/14786410802228637"},{"key":"2026041409463479149_j_znc-2020-0070_ref_054_w2aab3b7c13b1b6b1ab2b2c54Aa","doi-asserted-by":"crossref","unstructured":"Crowell, PL. Monoterpenes in breast cancer chemoprevention. Breast Canc Res Treat 1997;46:191\u20137. https:\/\/doi.org\/10.1023\/a:1005939806591.","DOI":"10.1023\/A:1005939806591"},{"key":"2026041409463479149_j_znc-2020-0070_ref_055_w2aab3b7c13b1b6b1ab2b2c55Aa","doi-asserted-by":"crossref","unstructured":"Maltzman, TH, Hurt, LM, Elson, CE, Tanner, MA, Gould, MN. 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